BCAAs on Lifespan?
ta5
15 Feb 2014
What's the latest, or the consensus? There were several conflicting studies discussed a few years back that BCAAs extend lifespan in mice, but that Leucine contributes to insulin resistance, or improves insulin sensitivity. From these threads, I decided to stop taking BCAAs at that time:
http://www.longecity...ne-restriction/
http://www.longecity...ce-live-longer/
Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective.
Valerio A, D'Antona G, Nisoli E.
Aging (Albany NY). 2011 May;3(5):464-78. Review.
PMID: 21566257
Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways.
Xiao F, Huang Z, Li H, Yu J, Wang C, Chen S, Meng Q, Cheng Y, Gao X, Li J, Liu Y, Guo F.
Diabetes. 2011 Mar;60(3):746-56.
PMID: 21282364
Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice.
D'Antona G, Ragni M, Cardile A, Tedesco L, Dossena M, Bruttini F, Caliaro F, Corsetti G, Bottinelli R, Carruba MO, Valerio A, Nisoli E.
Cell Metab. 2010 Oct 6;12(4):362-72.
PMID: 20889128
Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice.
Iwasa J, Shimizu M, Shiraki M, Shirakami Y, Sakai H, Terakura Y, Takai K, Tsurumi H, Tanaka T, Moriwaki H.
Cancer Sci. 2010 Feb;101(2):460-7.
PMID: 19906067
Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.
Shimizu M, Shirakami Y, Iwasa J, Shiraki M, Yasuda Y, Hata K, Hirose Y, Tsurumi H, Tanaka T, Moriwaki H.
Clin Cancer Res. 2009 May 1;15(9):3068-75.
PMID: 19366832
http://www.longecity...ne-restriction/
http://www.longecity...ce-live-longer/
Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective.
Valerio A, D'Antona G, Nisoli E.
Aging (Albany NY). 2011 May;3(5):464-78. Review.
PMID: 21566257
Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways.
Xiao F, Huang Z, Li H, Yu J, Wang C, Chen S, Meng Q, Cheng Y, Gao X, Li J, Liu Y, Guo F.
Diabetes. 2011 Mar;60(3):746-56.
PMID: 21282364
Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice.
D'Antona G, Ragni M, Cardile A, Tedesco L, Dossena M, Bruttini F, Caliaro F, Corsetti G, Bottinelli R, Carruba MO, Valerio A, Nisoli E.
Cell Metab. 2010 Oct 6;12(4):362-72.
PMID: 20889128
Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice.
Iwasa J, Shimizu M, Shiraki M, Shirakami Y, Sakai H, Terakura Y, Takai K, Tsurumi H, Tanaka T, Moriwaki H.
Cancer Sci. 2010 Feb;101(2):460-7.
PMID: 19906067
Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.
Shimizu M, Shirakami Y, Iwasa J, Shiraki M, Yasuda Y, Hata K, Hirose Y, Tsurumi H, Tanaka T, Moriwaki H.
Clin Cancer Res. 2009 May 1;15(9):3068-75.
PMID: 19366832
tunt01
13 May 2019
https://www.nature.c...2255-019-0059-2
Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control
SM Solon-Biet, VC Cogger, T Pulpitel, D Wahl, X Clark… - Nature Metabolism, 2019
Elevated branched-chain amino acids (BCAAs) are associated with obesity and insulin resistance. How long-term dietary BCAAs impact late-life health and lifespan is unknown. Here, we show that when dietary BCAAs are varied against a fixed, isocaloric macronutrient background, long-term exposure to high BCAA diets leads to hyperphagia, obesity and reduced lifespan. These effects are not due to elevated BCAA per se or hepatic mammalian target of rapamycin activation, but instead are due to a shift in the relative quantity of dietary …
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