LONGECITY

An experimental cancer drug appears to be able to reverse schizophrenia in mice, researchers at Johns Hopkins Medicine have found.
The team say an experimental anticancer compound can reverse behaviours associated with schizophrenia in adolescent mice with the rodent version of the disease.
They also discovered some of the lost brain cell function was restored in mice being administered the cancer drug.
Published in the Proceedings of the National Academy of Sciences, the researchers discovered the compound - FRAX486 – appears to halt a pruning process in the schizophrenic brain in which vital neural connections are destroyed.
The drug is one of a class of compounds called PAK inhibitors which provide some protection from brain damage caused through inherited disease. There is also evidence to show the drug could be used to treat Alzheimer's, while previous studies have found the PAK protein can initiate cancer and cell growth, meaning inhibitors could be developed to fight cancers.
The team said they were able to restore disabled neurons in adolescent and young adult mice with schizophrenia through FRAX486.
Study leader Akira Sawa said: "By using this compound to block excess pruning in adolescent mice, we also normalised the behaviour deficit. That we could intervene in adolescence and still make a difference in restoring brain function in these mice is intriguing."
In their experiments, the researchers reduced the expression of a gene called Disrupted-in-Schizophrenia 1 (DISC1), which appears to regulate the fate of neurons involved in higher order functions like information processing.
The deficit in DISC1 caused deterioration of parts of the brain that help neurons to communicate with one another. It also means the regulation of another protein, Rac1, cannot be controlled. Excess Rac1 leads to excess PAK in mice.
By reducing the activity of PAK, the team was able to protect the mice against the effects of having too little DISC1.
It is not yet known if PAK is elevated in the brains of humans with schizophrenia, meaning further research is needed before the drug is considered for use in humans.
"Drugs aimed at treating a disease should be able to reverse an already existing defect as well as block future damage," Sawa said. "This compound has the potential to do both."

http://www.ibtimes.c...ia-mice-1442916

Btw, I found this News on Reddit/Science
http://de.reddit.com...after=t3_21g8rj

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so is there an alternative which is similar that we can test?

As far as I understood, If You´re out of Adolescence, it Would not help.
Since the pruning occurs in this timeframe.

Look out in google for (herbal/nautral) PAK inhibitors, and make sure they are premerable to the Blood Brain Barrier.
Edited by Flex, 03 April 2014 - 10:07 AM.

Posted on my thread http://www.longecity...876#entry653876, but I'll post here too:

The subconscious <-> conscious tiers age each other. The conscious tier is evolved by the subconscious tier and thus determines its fate in maturation and ageing. The proteins involved in this story regulate this relationship in tandem with experience through developement modulating it.
Top-down supression(of subconscious emotion/pain -> subconscious behavior) is probably facilitated by opioids which supress subconscious behavior, project(sublimate) the "needs for outcome"(which enables the conscious to project the solution outward or inward depending on positive or negative - causing paranoid-schizoid reasoning described best by m. klein) to the conscious to produce a behavior adaptation as the subconscious is "scared" of what is about the happen the conscious is set to avoid it in a smarter way(that is conscious of group ally behavior and enemy behavior and can provide better guidance than subconscious guidance).


This is how the body evolves and how tissues develop, mature and age each other depending on how the later evolved/developed parts serve the earlier evolved/developed parts. This provides a mechanism that only the later evolved parts are easily mutated or degenerated by not even developing them in the offspring.

could be a good preventative for children at risk

As far as I understood, If You´re out of Adolescence, it Would not help.
Since the pruning occurs in this timeframe.

Look out in google for (herbal/nautral) PAK inhibitors, and make sure they are premerable to the Blood Brain Barrier.

I would think that as part of a regenerative therapy it may work very well. Parts of the brain are able to regenerate and have their own stem cells. If they have their own stem cells or stemcells in the brain can be directed to differentiate into the pruned cells, then repair is certainly possible if you can stop the process that prevents the brain from repairing itself.

I would think that as part of a regenerative therapy it may work very well. Parts of the brain are able to regenerate and have their own stem cells. If they have their own stem cells or stemcells in the brain can be directed to differentiate into the pruned cells, then repair is certainly possible if you can stop the process that prevents the brain from repairing itself.

As far as I remeber( so take it with a grain of salt) is that the Brain kills purposely some Neurons to clear the way for Synapses growth

Hi all, i saw your forum and would ask did someone buy this FRAX486 and tested it. I have a link where u can purchase it but in some reason forum says its a spam so i cant post it. 

tocris .c om/dispprod.php?itemld=415470

The Problem is, that YOu have to take it during adolescence.

So if You are arround 18+ Years, this would not help You.

 

I believe that this is the reason why nobody has tried it 

Not sure about it, because in news about this drug also says that it maybe can be used by people with alzheimer, but as we know alzheimer is late-age illness, so i think it can help with schizophrenia even after you are 18 years, im just not sure about doses etc so i could buy it.

At least some forms of propolis are apparently PAK inhibitors.

http://www.ddtjourna...c.php?docid=482

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What if this was developed to the point where they could make a schizophrenia vaccine for at-risk children?