LONGECITY

While I was re-reading the Baati/Moussa-paper and by looking at Fig. 2 c, (showing spleen sections of oral c60-00-fed rats), I was wondering about the fate of those macropahges with c60 inside and as well of the ingested c60. What are these macropahges doing if they are full? Do they kind of "burst" (likely without doing any harm to the envoronment), and subsequently the freed C60s are either eaten up by other macropahges or start traveling around our bodies via blood?

The same is for hepatic Kupfer cells, which I suppose do also phagocyte c60-oo.

Has anybody already put some c60-oo in a culture with human macropahges yet?

Another thing, which catched my eyes was, that the C60oo-livers were quite darker (albeit quite healthy looking) as compared to the oo-only livers (see Fig 4.).

Any other c60-news out there?

regs

MM

Been reading up lately on macrophages, myself. As I understand it they feed any dying cells to lysosomes which burn then up with an oxidative digestive process. If the cell they're eating has any c60 in it, I imagine the liberated c60 would get absorbed by the lysosome itself, which is composed primarily of lipids. If that lysosome was already saturated with c60, I guess it would form into a crystal instead of an adduct. Don't know it that would harm it or not, but in any case that lysosome would eventually die and get fed to a different lysosomes. For lysosomes to ever reach c60 saturation levels, the volume of c60/evoo consumed would have to be exceed the lipid content of the entire body. I guess it's theoretically possible to OD on c60/evoo but I expect that much olive oil wouldn't be too good for you either.

Howard