LONGECITY

Hi.

Anyone know any not controlled (schedule I and II) norepinephrine releasing agent (NRA) and norepinephrine reuptake inhibitor (NRI)? And where to buy them?

Same question for for dopamine.

I am looking for enough selective substances (substances that act only on norepinephrine and 'only' on dopamine) and not selective substances (substances that act on norepinephrine and dopamine).

In particular, anyone know some legal substituted amphetamine (research chemical)?

http://en.wikipedia....releasing_agent
http://en.wikipedia....ptake_inhibitor
http://en.wikipedia....ine_transporter
http://en.wikipedia....ted_amphetamine

Legal where?

US, UK, .... different countries have different laws regarding exotic chemicals.

Legal where?

 

US, UK, .... different countries have different laws regarding exotic chemicals.

Primarily UK, but the country isn't important, if for example is legal in Holland or another country it's better than nothing.
 

There is no such thing as a totally selective NRA, NRI, DRA, or DRI. It's impossible both in practice and in principle to produce such a compound, since the catecholamines are so similar in structure. 

If you want a research chemical DRI, I would look into ethylphenidate. Fluoroamphetamines are popular as well, but they're extremely dangerous.  

Maybe not exactly what you're looking for but I think Psoralea colylifolia might be one of your best natural bets, Its an NDRI and MAO-b inhibitor.

Its been a while since I tried it, but the main effects I noticed is that it seemed to make me rather impulsive, while i was looking more for a motivational boost.

Chaenomeles speciosa is terribly understudied but seems to have decent selective DRI abilities that are dose dependent.

Scutellaria baicalensis and Melissa officinalis have DRI's but they also interact with ALOT of other things (e.g. IIRC they are both positive allosteric modulators of GABA A receptors), only selective in reuptake inhibition.

There is no such thing as a totally selective NRA, NRI, DRA, or DRI. It's impossible both in practice and in principle to produce such a compound, since the catecholamines are so similar in structure. 

 

If you want a research chemical DRI, I would look into ethylphenidate. Fluoroamphetamines are popular as well, but they're extremely dangerous.  

For this I have write ENOUGH selective.
Anyway, It's acceptable a monoamine releasing agent (MRA) with an high equilibrium dissociation constant (EDK) for 5HT (serotonin), and low for dopamine, and very low for norepinephrine.

SWIM don't want increase the level of serotonin.

d-amphetamine has a good binding profile  (7; 110; 1,765).
SWIM is looking for an MRA with a similar profile: NE=[0,30]; DA=[0,200]; 5HT>800

http://en.wikipedia....releasing_agent

SWIM already know Ethylphenidate. It is an inhibitor and work more on dopamine than on norepinephrine.

Anyway it is enough good.

 

Methylphenidate's mechanism of action involves the inhibition of catecholamine reuptake, primarily as a dopamine reuptake inhibitor.

http://en.wikipedia....Methylphenidate

 

Ethylphenidate acts as both a dopamine reuptake inhibitor and norepinephrine reuptake inhibitor,

[...]

Ethylphenidate is more selective to the dopamine transporter (DAT) than methylphenidate, having approximately the same efficacy as the parent compound,^[4] but has significantly less activity on the norepinephrine transporter (NET).

http://en.wikipedia..../Ethylphenidate

SWIM is interested in releasing agents and inhibitors for norepinephrine and dopamine, but specially in NRA.

PS. Thanks for the replies