LONGECITY

This is a major breakthrough. This broad-spectrum oncogene has been implicated in a panoply of cancers. Now, a small interfering RNA has been discovered which is able to destroy the majority of KRAS precursor mRNAs as soon as they roll off the assembly line in the cytoplasm.

"When they delivered these sequences into tissue culture cells, they found that the siRNAs destroyed more than 90 percent of the KRAS gene messages, significantly impairing the growth of cancer cell lines."

If we combined this with a multipath strategy, i.e. kill (merely) most instances of the most pathologically overexpressed oncogenes, then we might be able to revert stage 4 into stage 1, i.e. resectable localized cancer. (We often get excited about developments like this, on the pipe dream that we can hope to shut down 100% of the overexpressed genes and thereby kill the cancer without side-effects. That's unrealistic, but nonetheless the mainstay of our current pharmocratic approach to chemotherapy. It would be more effective, I think, to target many pathways an in incomplete but multipartite fashion, in the hopes of creating a high-dimensional constraint escape problem which a cancer cannot solve (yes, it is a computer) before it is surgically resected, or better yet ablated with ultrasound or fried-in-place with irreversible electroporesis.)

http://www.scienceda...41113123320.htm

siRNA-ceuticals... coming soon to an unregulated biohacker dystopia near you! Watch for this and other siRNAs to be produced in the usual "third world" markets first.

NOTE: siRNA is also a major HIV research vein, even though deasserting the CCR5 and CXCR4 T-cell receptors is probably a superior approach.

[Mods: Why do we have "Medicine & Diseases"? It's too broad. How about "Cancer"? No wait, that's also too broad. OK, but some more acute classification.]