LONGECITY

This forum is devoted to nutrients, botanicals, safe drugs and anything else that has quality published data supporting its action(s) in improving memory. Please cite studies as you contribute and let's all see how well we can improve our "smarts," especially over the long term.

After reading the Loriaux study years ago, and after taking high-dose niacin for 40+ years, I decided to try xanthinol nicotinate about five years ago.

 

The Loriaux study showed as much as 40% improvement in short-term memory and sensory register with plain niacin for younger people.

 

Xanthinol improved short-term memory, sensory register and long-term memory for older people and now I'm moving into the older years.

 

The authors said, "These results are by the supposed activity of nicotinic acid at the cell membrane, improving neuronal transmission, and of xanthinol nicotinate inside the cell, enhancing cell metabolism and oxygen supply in the brain."

 

I was taking it regularly because I did notice more clarity, precision and subtle improvements in memory. However, the web site that sold it disappeared and I could find no source until recently when I got the following site to carry it. (https://www.buy-pharma.com/Complamina-Retard-p-2836.html)

The 500 mg slow-release (Retard) version yields the 141.7 mg (t.i.d) in the study, and to be clear, I tend to take more than three a day, as it seems to work even better.

 

Resuming taking it, after not having it for a year caused noticeable improvements in overall mental clarity and memory within the first week.

 

The Loriaux study full text said, "“Though the mechanism of action of xanthinol nicotinate is as yet not quite clear, there is evidence that it influences cell metabolism through [stimulating the synthesis of] the nucleotides NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate)…”

 

With NAD being a topic of considerable interest these days. I wonder how xanthinol nicotinate compares to other niacin-based molecules that increase NAD.

 

Perhaps a chemist here can provide an answer to that question.

Edited by mikey, 29 November 2014 - 08:28 PM.

Bacopa or brahmi

 

It improves retention, reduces forgetfulness [1, 2,], upregulates neurotrophic factors in the healthy [3], rapidly reverses induced dementia [4, 5, 6], and has only mild side effects. Great stuff.

 

Xantinol nicotinate 

http://en.wikipedia....inol_nicotinate

 

It could be the nicotinic acid. I've been taking NR for almost a year and my short term memory has increased noticeably. I think anything raising NAD levels will most likely produce these effects.

 

http://www.life-enha...heimers-disease

 

http://news.uci.edu/...mptoms-lesions/

 

While it seems to improve memory for the declining older population it may not produce those effects in the young. Time will tell as human studies are still ongoing.  

 

 

 

 

Well, the question is does xanthinol nicotinate raise NAD levels better than plain niacin.

 

For us older people, xanthinol worked better than niacin did for us or for younger people,as it helps deliver niacin inside cells, where plain niacin doesn't do so well.

 

Perhaps a chemist here could hypothesize.

Bacopa or brahmi

 

It improves retention, reduces forgetfulness [1, 2,], upregulates neurotrophic factors in the healthy [3], rapidly reverses induced dementia [4, 5, 6], and has only mild side effects. Great stuff.

 

Good data! Bacopa is definitely on the list.

 

Let's create a definitive list of easily accessed supplements that improve various aspects of memory via this forum.

another collector all "natural" supplement fetishist with another list of "lets make a list of natural supplements to take for whatever condition"

I found Hydergine very helpful decades ago. I think if I had kept taking it and not sttopped when I could just about get by I would not be in the mess I am today

It's difficult to know what works because there are so many reasons that people suffer form cognitive impairment. Life Extension has a product called Cognitex that I take. It has a variety of ingredients including the usual ones :
Alpha GPC
Phosphatidyl serine
Pregnenalone
Some people believe and there Is some literature to support DHA supplementation.
I've also begun taking piracetam.
http://www.antiaging...ginal-nootropic

I am a 58 yo male with no current impairment other than what one would expect at this age. I'm taking these products to improve my memory and support future brain health
Edited by Kevnzworld, 02 December 2014 - 03:26 AM.

"... and rosemary for remembrance"  from Shakespeare's Hamlet

 

Phytochemicals in rosemary have been shown to improve recall in some studies. 

"... and rosemary for remembrance"  from Shakespeare's Hamlet

 

Phytochemicals in rosemary have been shown to improve recall in some studies. 

 

I have a rosemary aromatherapy diffuser in my office and it is pleasant. Perhaps it does brighten mood and improve some aspects of cognitive function. 

 

But, the single thing that I notice significantly more than everything else is xanthinol nicotinate.

 

I take baccopa, huperzine, ginkgo, vinpocetine, high-dose niacin and on and on, but none of them has provided the clear elevation in mood and the definite improvement in mental clarity that XN gives me.

 

And I saw a good friend yesterday over food and at the end of our time he told me, "Whatever you are doing, keep doing it. "You look fantastic." He wasn't just talking about my physical appearance.

 

I am quite serious. Xanthinol nicotinate does far more than plain niacin for me.

 

However, the Loriaux (attached) showed that it improved both short and long-term memory for older people, like over 75, not younger people.

 

At 61, I am in the so-called "middle-age" group, yet I notice a tremendous difference. 

 

I am also taking 2 - 3 times more than they gave subjects in the Loriaux study.

another collector all "natural" supplement fetishist with another list of "lets make a list of natural supplements to take for whatever condition"

 

You overgeneralize erroneously.

 

The title of this forum is "Nutrients/Drugs For Improved Memory Based On Quality Studies."

 

There is no "all natural" fetish here.

 

It seems that most people on this site are greatly interested in whatever improves lifespan and cognitive function, whether natural or not.