LONGECITY

Hello, resveratrol pros. I'm finding conflicting reports about resveratrol both inhibiting and activating SIRT3. The "original source" inhibition articles were on zebrafish in one case and seemingly only working with a particular substrate in vivo in another. Still, dozens of other papers confidently state that RESV inhibits SIRT3 while fistfuls more state that it self-evidently activates it.

Anyone care to weigh in? Thanks in advance.

I suspect that the dosage accounts for the difference. I surmise lower concentrations activate it, high doses inhibit.