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Yohimbine and blood sugar?

fiftyyy's Photo fiftyyy 22 Jan 2015

Hey guys,

 

I recently got 10 grams of Yohimbine hcl from SP, ive been taking it for two days in a row and i noticed profound positive effect (for me personally) and i am wondering whats the mechanism behind it and how to make it sustainable? Some quick background info im 25 yo about 185cm 105kg (i have a belly and quite big upper body, not extremely obese) with very stale way of life, with very little physical activity besides going to the offices and back. I am looking to trim some weight off and decided to try yohimbine + forskolin. I wanted to try both substances apart so that i can get a feel for them individually and i started with the yohimbine. Usually i get sleepy after a meal to the point i was avoiding lunch because in some instances i was struggling to stay awake, really unpleasant situation especially when you have work to do. So the last couple of days i took ~20mg of yohimbine on an empty stomach, on day one, two or three hours later i had some cheese toasts with a soda, no signs of drowsiness/sluggishness at all. Even better i felt fresh and awake, i felt more physically capable of doing stuff and no usual bloating i get from the bread and soda. Yesterday i drank about one litre of pepsi with very little food, tbh my energy seems increased from carbs without the usual sugar crash, Also i have decreased need for sleep. Can you help me out figuring this out? I remember reading somewhere that yohimbine lowers blood sugar. Could this be the case? Also i looking for long terms alternatives for yohimbine, resveratrol perhaps? Any input would be greatly appreciated

 

Cheers


Edited by fiftyyy, 22 January 2015 - 05:06 PM.
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niner's Photo niner 23 Jan 2015

It's an adrenergic agonist, but it also interacts with other receptors.  It's kind of dangerous stuff.  If you're interested in losing weight, I'd consider ditching the soda and other sugary stuff.   Yohimbine is a stimulant, among other things, but my impression is that the results will not last, 

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Alpharius's Photo Alpharius 23 Jan 2015

Regarding weight loss, the results achieved with yohimbin are between bad and controversal. Even a higher dosage of over 40 mg daily over 6 months did not result in weight loss in 30 tested men (1). Further there are also alpha receptors on the pancreas, where they regulate the insulin release. So when you inhibit those receptors and eat something carbohydrate/protein rich the insulin release will be much more higher with yohimbine (2).

 

Yohimbine has been hyped by the bodybuilding community, but it is useless.

 

(1) Yohimbine does not affect fat distribution in men.

Sax L. Int J Obes. 1991 Sep;15(9):561-5.

PMID:1960007

 

(2)

Involvement of a central nervous pathway in yohimbine-induced insulin secretion.

Ribes G, Hillaire-Buys D, Gross R, Blayac JP, Loubatières-Mariani MM.

Eur J Pharmacol. 1989 Mar 21;162(2):207-14.

PMID:2566496

 

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AlexCanada's Photo AlexCanada 29 May 2015

 

Regarding weight loss, the results achieved with yohimbin are between bad and controversal. Even a higher dosage of over 40 mg daily over 6 months did not result in weight loss in 30 tested men (1). Further there are also alpha receptors on the pancreas, where they regulate the insulin release. So when you inhibit those receptors and eat something carbohydrate/protein rich the insulin release will be much more higher with yohimbine (2).

 

Yohimbine has been hyped by the bodybuilding community, but it is useless.

 

(1) Yohimbine does not affect fat distribution in men.

Sax L. Int J Obes. 1991 Sep;15(9):561-5.

PMID:1960007

 

(2)

Involvement of a central nervous pathway in yohimbine-induced insulin secretion.

Ribes G, Hillaire-Buys D, Gross R, Blayac JP, Loubatières-Mariani MM.

Eur J Pharmacol. 1989 Mar 21;162(2):207-14.

PMID:2566496

 

 

My head is foggy right now but do you mean Yohimbine is more likely to reduce blood sugar? I hope not.  I get so tired after most meals due to suspected hypoglycemic effect.  

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Alpharius's Photo Alpharius 29 May 2015

Yes Yohimbine will spike your Insulin when you take it with food, so it will bring down your blood sugar. Beside this it is worthless in regard to fat loss. Maybe and just maybe it could work combined with caffeine and fasting or very low carb diet. But to be honest I would not waste my time with it.
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fiftyyy's Photo fiftyyy 31 May 2015

Yes Yohimbine will spike your Insulin when you take it with food, so it will bring down your blood sugar. Beside this it is worthless in regard to fat loss. Maybe and just maybe it could work combined with caffeine and fasting or very low carb diet. But to be honest I would not waste my time with it.

Agreed, i havent noticed much change in terms of fat loss, however, i like the spike in energy it gives me during athletic activities, its a decent stimulant that i use from time to time.

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mustardseed41's Photo mustardseed41 31 May 2015

 

Regarding weight loss, the results achieved with yohimbin are between bad and controversal. Even a higher dosage of over 40 mg daily over 6 months did not result in weight loss in 30 tested men (1). Further there are also alpha receptors on the pancreas, where they regulate the insulin release. So when you inhibit those receptors and eat something carbohydrate/protein rich the insulin release will be much more higher with yohimbine (2).

 

Yohimbine has been hyped by the bodybuilding community, but it is useless.

 

(1) Yohimbine does not affect fat distribution in men.

Sax L. Int J Obes. 1991 Sep;15(9):561-5.

PMID:1960007

 

(2)

Involvement of a central nervous pathway in yohimbine-induced insulin secretion.

Ribes G, Hillaire-Buys D, Gross R, Blayac JP, Loubatières-Mariani MM.

Eur J Pharmacol. 1989 Mar 21;162(2):207-14.

PMID:2566496

 

 

It's far from useless and has been proven to work for many years now IF used correctly and used for specific reasons like stubborn fat loss.. Those links are not using it in the right way for fat loss. And using dogs for the study???Please.....wonder if the dogs were doing fasted cardio????? I'd personally not even bother with Yohimbine unless your chasing down the last bit of stubborn bodyfat. And your not chasing it if your 10%+ bodyfat.

http://forums.lylemc...read.php?t=4076

 

http://examine.com/s...ents/Yohimbine/


Edited by mustardseed41, 31 May 2015 - 04:07 PM.
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Alpharius's Photo Alpharius 31 May 2015

 

Please.....wonder if the dogs were doing fasted cardio?????

Mustardseed sorry but your interpretation of the study done in dogs is strange. They have just shown, that by inhibiting the alpha receptors on the pancreas yohimbine leads to a stronger surge of insulin in dogs (and in rats too). It is just the biochemical pathway, which is highlighted through this research. So the alpha-adrenoceptors just take a part in insulin regulation, by inhibiting them the production of insulin is stronger after glucose intake. It is a conserved pathway in several mamals.

 

Beside the study for fat loss in humans, where yohimbine was useless at a high dose, there are other clinical studies which show the same. Also a study where they could not find any kind of change in fat tissue distribution. Just look up in pubmed.  Ephedrine is one of the rare really effective fatburners, but it is banned and leads to a higher risk of psychological disorders rather then cardiovascular problems (reason it was banned for). Other fat burners are not really interesting or more dangerous. As I said in my last comment: Yohimbine could be perhaps useful during a fast, but not for other diets. The problem most people have with dieting is their nutrition, instead of fixing this they try fatburners often with a BF over 10-15%.

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Ark's Photo Ark 01 Jun 2015

Yohimbine is a "dirty" supplement, and should be only used by experienced supplementers, under medical care if predisposed ailments are present.
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