LONGECITY

My skin has gotten quite lifeless and dull lately and I suspect it's primarily due to my use of amphetamine and other stimulants.
Can anyone think of any supplement that may help with this? Citrulline helps a bit but it makes me feel weird.

How's your diet?  Amps tend to kill people's appetite.  Maybe you just need more nutrients.

How's your diet?  Amps tend to kill people's appetite.  Maybe you just need more nutrients.

No no, that's not the problem.
I think it has to do with peripheral adrenergic receptors getting stimulated, causing the body to downregulate/desensitize something..

Are you exercising?  There's some study on exercise improving/maintaining skin quality.

 

How's your diet?  Amps tend to kill people's appetite.  Maybe you just need more nutrients.

 

No no, that's not the problem.
I think it has to do with peripheral adrenergic receptors getting stimulated, causing the body to downregulate/desensitize something..

I googled around a bit; you aren't the only person to report skin problems from amphetamines.  Things to try would be reducing your dose as much as possible, making sure that you're getting enough sleep, eating right, and getting enough exercise, and looking into topicals for you skin.  Retinoids are the bomb if you can tolerate them.  I like retinaldehyde, sold under the trade name "Retrinal"; it's milder than retinoic acid but stronger than retinol.   As far as supplements go, I'd look at a bioavailable silica source like BioSil or JarrowSil, hydrolyzed collagen, essential fatty acids, and a multivitamin as a start.

As far as supplements go, I'd look at a bioavailable silica source like BioSil or JarrowSil

 

I am curious. Would silicon-rich mineral water be beneficial on this front? I have been using it regularly since I saw the study on aluminium excretion and I wonder if it would have any significant effect for the purposes BioSil/JarrowSil is primarily used for (collagen synthesis, skin/hair, joints, bones, arteries). My silicon intake from this source is several times the amount in one serving of the supplement but I understand that bioavailability is of the essence. From what I read, silicon is found in mineral water as orthosilicic acid -same for beer-, and this is allegedly the most readily bioavailible form in the diet, although it is not stabilized like the supplemental form. See for example: 

http://www.ncbi.nlm....les/PMC2658806/

 

I cannot tell if it has had any noticeable effect on my skin due to a lot of confounders -including JarrowSil- and the fact that my skin is already in a very good condition. 

In this paper, they looked at the effects of drinking over 2 liters/day of mineral water vs tap water.  The two had both good and bad effects, although neither mineral nor tap water changed skin surface morphology, which I take to mean "wrinkles".  That's something that BioSil was shown to alter.   It might be the case that over 2L/day is too much water.  So I don't know.  The mineral water results are clearly different than the tap water results, and high silica water looks good epidemiologically with respect to Alzheimers.    I'd expect Bio(or Jarrow)Sil to also have a positive effect on AD risk, but I don't know that anyone has looked at that.  (It would be a long expensive study.)  If you're awash in cash, use both.  Given the cost of high silica mineral water, it's probably cheaper to go with the supplements.

Vitamin E, Pregnenolone and DMAE,

Look em up