LONGECITY

hi,

does anyone know any drugs that lower 

i took atemoxitne and it caused all my problems. it made me not socially etc...

My most basic knowledge and successful items would be;

L-theanine

Magnesium

Lithium orotate

...

From the list above a QUALITY Magnesium should calm those nerves and set you straight.(Avoid Mag Oxide)

But these are,

IMO & IME statements

How long have you been taking Strattera it for? Cymbalta initially made me anti-social as well but after several weeks, I returned closer to my old normal self.

Atomoxetine doesn't really lower norepinephrine, it's a reuptake inhibitor and as such it will increase the NE effects.

Clonidine works by agonizing NE auto receptors and effectively reduces the amount of released norepinephrine. A good anxiolytic and non-addictive sleep aid.

I would avoid blaming any single neurotransmitter for your issues. I've learned this the hard way. 

Yeah, of course it isn't as easy and well.. "if you got issues" is a bit indifferent, to say the least.

But there are indeed conditions where lowering NE is of benefit. Panic attacks, anxiety for example. After effects of psychostimulants. Insomnia. PTSD.

Dopamine beta-hydroxylase inhibitors

^ This is the interesting part about disulfiram, yes. It seems to increase dopamine levels in favor of less norepinephrine. If it just wouldn't have this alcohol metabolism blocking property, not that I'm a regular drinker at all, but I don't need to get panic reactions from some alcohol in a pasta sauce or something. Could make an interesting ADHD med.

Dopamine beta-hydroxylase inhibitors

Do you have any natural supps for it?

I would avoid blaming any single neurotransmitter for your issues. I've learned this the hard way. 

Thank you for this reminder. I may PM you when I have enough functionality to ask you a few questions on how to address more than one neurotransmitter group, if thats ok? 

Or just write them down here

 

Dopamine beta-hydroxylase inhibitors

 

Do you have any natural supps for it?

 

St. John's Wort does that, I think Ginseng too.

Thanks Galaxyshock.

I also found this other one Nepicastat, but  I don't know if it has the same effect on alcohol.

It's a "Quoted" post.No...

Definitely do not take 60 mg Elemental Zinc daily.

Guanfacine in essential hypertension: effect on blood pressure, plasma noradrenaline concentration and plasma renin activity.

 

Guanfacine induced a decrease in plasma noradrenaline concentration and plasma renin activity concomitant with a fall in blood pressure and heart rate in both the acute and the chronic study.

 

It's a "Quoted" post.No...
Definitely do not take 60 mg Elemental Zinc daily.

Taurine seems interesting, I might give it a go for my depression/anxiety and other cognitive issues. People have recently started discussing the benefits of taurine for Isotretinoin induced long-term damage in acne.org forum.

Taurine seems interesting, I might give it a go for my depression/anxiety and other cognitive issues. People have recently started discussing the benefits of taurine for Isotretinoin induced long-term damage in acne.org forum.

Supplemental (oral) taurine actually induces anxiety whereas research shows, only Injected taurine reduces anxiety.

Effects of taurine on anxiety-like and locomotor behavior of mice.

http://www.ncbi.nlm....pubmed/19239151

Alternatively Magnesium Taurate would be more effective, Contains Magnesium bound to amino acid, taurine.Added bonus Magnesium slightly hinders catecholamine release such as adrenaline, and Mag defiency causes anxiety to a certain degree and is very common in this day and age.

 

 

AND FINALLY!

 

The magic drug you've been looking for! The drug that will actually directly block DBH! The enzyme that converts dopamine to noradrenaline. Your number one enemy! It is called "Disulfiram". Commercially known as Antabuse. People take it because it inhibits the enzyme that hydrolyzes alcohol. so when they drink they get panic attack like symptoms. Anyway. This drug also significantly inhibits DBH! So you will eventually have higher dopamine and lower noradrenaline levels! I suggest you take 5mg-8mg per lbs daily! keep in mind that you can NOT drink on this drug at all!!!!!!!!!

 

So your cure as a started should look like this:

(Do this for 2 months)

Daily:

*60mg zinc

*800mg phosphatidylserine

*6g Taurine

*10.000 IU Vitamin D

*1000 mg Disulfiram

 

 

 

Prognosis:

 

Unfortunately our bodies are prone to this condition so we need to maintain a healthy state. Once you feel good, get another blood test done. If you're happy with the results. Stop taking disulfiram. You should probably lower your zinc and taurine intake too.

 

Your maintenance dosage should look like this:

 

*30mg zinc

*400mg phosphatidylserine

*3g Taurine

*5.000 IU Vitamin D.

 

I would say you will feel your old self within 3 months. But everybody is different. Good luck and let me know about your process!

 

I checked here in Canada and  I don't think that Disulfiram is available. Can you recommend something similar? Also would the enzyme inhibitor stop crucial functioning levels of Norepinephrine for Athletic power and stamina and for Fight or flight needs like running from a Bear, Dog etc... lol  

Alternatively, you could look into Catuaba, CoQ10, and/or Green Tea Extract w/ Theanine. All of which act on Dopamine, and clinically shown to be effective but do not on the same enzyme as Disulfiram, unfortunately...

 

Do you have any natural supps for it?

St. John's Wort does that, I think Ginseng too.

 

Gardenia Jasminoides

Monoamine Oxidase and Dopamine β-Hydroxylase Inhibitors from the Fruits of Gardenia jasminoides

http://www.ncbi.nlm....les/PMC3792221/

From the list above a QUALITY Magnesium should calm those nerves and set you straight.(Avoid Mag Oxide)

Look into magnesium-L-threonate.

The bioavailabilty of Mag is limited in contrast to threonate and perhaps the sulfate form.

I guess those are the references IIRC:

Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model

http://www.ncbi.nlm....les/PMC4172865/

https://www.reddit.c...sium_threonate/
 

Great finding Flex 

Some details from the study provided by Flex

With this study we can say that,

Combo for DBH inhibition:

Protocatechuic acid + Urosolic Acid

Combo for  MAO-B inhibition:

6'-O-trans-p-coumaroylgeniposide + 3,5-di-hydroxy-1,7-bis(4-hydroxyphenyl) heptane + Geniposide

Extract Name                =  Effect                                                         | Amounts

=======================================================================

===========================================================================================

 

 

Abstract

This research was designed to determine what components of Gardenia jasminoides play a major role in inhibiting the enzymes related antidepressant activity of this plant. In our previous research, the ethyl acetate fraction of G. jasminosides fruits inhibited the activities of both monoamine oxidase-A (MAO-A) and monoamine oxidase-B (MAO-B), and oral administration of the ethanolic extract slightly increased serotonin concentrations in the brain tissues of rats and decreased MAO-B activity. In addition, we found through in vitro screening test that the ethyl acetate fraction showed modest inhibitory activity on dopamine-β hydroxylase (DBH). The bioassay-guided fractionation led to the isolation of five bio-active compounds, protocatechuic acid (1), geniposide (2), 6'-O-trans-p-coumaroylgeniposide (3), 3,5-d-ihydroxy-1,7-bis (4-hydroxyphenyl) heptanes (4), and ursolic acid (5), from the ethyl acetate fraction of G. jasminoides fruits. The isolated compounds showed different inhibitory potentials against MAO-A, -B, and DBH. Protocatechuic acid showed potent inhibition against MAO-B (IC50 300 μmol/L) and DBH (334 μmol/L), exhibiting weak MAO-A inhibition (2.41 mmol/L). Two iridoid glycosides, geniposide (223 μmol/L) and 6'-O-trans-p-coumaroylgeniposide (127μmol/L), were selective MAO-B inhibitor. Especially, 6'-O-trans-p-coumaroylgeniposide exhibited more selective MAO-B inhibition than deprenyl, well-known MAO-B inhibitor for the treatment of early-stage Parkinson’s disease. The inhibitory activity of 3,5-di-hydroxy-1,7-bis (4-hydroxyphenyl) heptane was strong for MAO-B (196 μmol/L), modest for MAO-A (400 μmol/L), and weak for DBH (941 μmol/L). Ursolic acid exhibited significant inhibition of DBH (214 μmol/L), weak inhibition of MAO-B (780 μmol/L), and no inhibition against MAO-A. Consequently, G. jasminoides fruits are considerable for development of biofunctional food materials for the combination treatment of depression and neurodegenerative disorders.

Its like saying Atemoxtine (NRI) long-term will decreases NA receptors. It does not that decrease NA receptors. It will increase them some what (or something got to do with auto receptors)

Its like antipsychotics, after stopping antipsychotics, you feel awful. no dopamine.

I have been trying Ursolic Acid  for about 2 wks now.  I got it in powder form, because the pills require too many pills per day.   The powder is 25% Ursolic Acid (Loquat extract) and I take ~425mg 3x per day.

What I first notice, is that I was able to sleep during the day, and it was a very deep sleep.  I can normally sleep 30min to 1hr during the day, but with this stuff I slept 3 to 4hrs.  This effect seems to has diminish a little bit.

A side effect I notice is that after a few hours I felt shaky.  As I was grabbing a spoon with my finger tips I felt as if my hand was shaking; I look at my hand closely, and I wasn't able to see it shake even though I was still feeling the same way.  This effect has pass as well, lasting only about a wk.  My reasoning is that Ursolic Acid may be a reversible inhibitor, and I got small spike of adrenaline.

I'm using Selegiline(1.25mg/d) & Rasagiline(.5mg/d), so they may have an effect on the strength of Ursolic Acid.

Side note:

Ursolic acid has an anabolic effect by working with IGF-1.

 

Symptoms related to high noradrenaline:

 

*ED

*Excessive wind

*Insomnia

*Anxiety

*Inflammation

 

 

Symptoms related to low dopamine:

*Difficulty concentrating

*weak orgasms

*low libido

*lack of motivation in life

 

Hold it there buddy, those symptions could relate to a plethoria of things, besides from that its highly individual, for example d2 is implicated in reward related decission making, in other words motivation but that doesnt mean low da is low motivation as its entirely dependent on the differened da receptors, sensivitys, brainareas, communication btw differened brain areas and so forth, high da can just do the exact opposite as well.

And then theres the prefrontal cortex etc.. 

Your list is extremely simplistic, what episode of dr phil did you get this from?