Questions about starting on Metformin
Sith 25 Dec 2015
Greetings everybody.
I have recently started taking Metformin. 850mg twice daily via oral route. Now I am slightly confused about Metformin since it has recently been suggested to improve life span. However, my question is that it has been associated with heart disease and also Alzheimers disease. Is it really wise to be taking Metformin at this point? I am a healthy 18 year old male without diabetes or any other illnesses.
I am also confused on the exact effect of Metformin on AD since some studies show it to be effective in preventing AD: http://www.nhs.uk/ne...s-dementia.aspx
And others show something drastically different: http://www.medscape....article/764413
Your help would be amazing!
stefan_001 25 Dec 2015
When you are 18 years old you can afford and should wait a couple decades in my opinion before doing any experimentation. Just imagine what science has discovered by then, its very likely that a lot of the questions on what helps to extend life span have been answered.
Sith 25 Dec 2015
When you are 18 years old you can afford and should wait a couple decades in my opinion before doing any experimentation. Just imagine what science has discovered by then, its very likely that a lot of the questions on what helps to extend life span have been answered.
I understand this but imagine the consequence of staring early. It would be amazing to slow down the ageing process as soon or even before it occurs. But what do you think about starting it?
stefan_001 25 Dec 2015
When you are 18 years old you can afford and should wait a couple decades in my opinion before doing any experimentation. Just imagine what science has discovered by then, its very likely that a lot of the questions on what helps to extend life span have been answered.
I understand this but imagine the consequence of staring early. It would be amazing to slow down the ageing process as soon or even before it occurs. But what do you think about starting it?
Imagine the consequence the other way what do you think of that......
stefan_001 25 Dec 2015
Edited by stefan_001, 25 December 2015 - 09:00 PM.
Sith 28 Dec 2015
How long have you been taking it & what things have you notice?
I have taken it for around a week now, I haven't noticed any effects actually.
noot_in_the_sky 28 Dec 2015
How long have you been taking it & what things have you notice?
I have taken it for around a week now, I haven't noticed any effects actually.
I guess that's to be expected. Most of this things are more noticeable on older people or those with a health problems. Anyhow, give it time and let us know if you have any changes. Hopefully you see something positive soon.
stefan_001 29 Dec 2015
http://www.longecity...ns/#entry756098
The decrease in transcription of neurotrophic factors and Nrf2 with chronic metformin intake, cautions of the possibility that extended metformin use may alter brain biochemistry in a manner that creates a vulnerable brain environment and warrants further investigation.
Edited by stefan_001, 29 December 2015 - 05:11 PM.
ceridwen 29 Dec 2015
Sith 29 Dec 2015
Sith you may want to read the latest posts in this thread:
http://www.longecity...ns/#entry756098
The decrease in transcription of neurotrophic factors and Nrf2 with chronic metformin intake, cautions of the possibility that extended metformin use may alter brain biochemistry in a manner that creates a vulnerable brain environment and warrants further investigation.
That's rather scary! I don't know what to make of that. Is it your opinion that I should stop taking Metformin? I like the idea of starting early but feel that it may be risky.
stefan_001 29 Dec 2015
I am not a doctor. Just trying to have common sense. My opinion you can find in posts above. Whats the difference in your case starting in couple years if science proofs its the real deal. Look at it this way. Lets say your life expectation is going to be 100+, then you are looking 80+ years of daily metformin...Sith you may want to read the latest posts in this thread:http://www.longecity...ns/#entry756098
The decrease in transcription of neurotrophic factors and Nrf2 with chronic metformin intake, cautions of the possibility that extended metformin use may alter brain biochemistry in a manner that creates a vulnerable brain environment and warrants further investigation.
That's rather scary! I don't know what to make of that. Is it your opinion that I should stop taking Metformin? I like the idea of starting early but feel that it may be risky.
Edited by stefan_001, 29 December 2015 - 06:44 PM.
noot_in_the_sky 29 Dec 2015
Stefan_001 has a good point. Perhaps you should wait for few year till you're 24 or 25. You will be surprise the advances that you will see in 7 yrs, for example in 7 years the community went from piracetam, hydegine, selegiline, & methylene blue to C60oo, Epithalon, N-Acetyl Epitalon Amidate, Dihexa, NSI, Sunifiram, coluracetam, unifiram, prl 8-53, phenylracetam... you get the idea. In fact, base on what Stefan_001 you got more to loose by starting now then in 7 years when their is more studies. 24 and 25 it's still a good age just ask anybody older then 25, and they will tell that their body was at it's peak at that age. Dam even many would wish to be like when they were 30.
Right now, you are better off just doing the typical exercise, diet, fasting, and natural herbs. I know... I know that's boring, but they have remain in every longecity member's stack for a reason... they work.
Kevnzworld 31 Dec 2015
Anyway metformin looks as though it's going to be big pharmas anti aging drug
No, not really. It's off patent and generic
DbCooper 31 Dec 2015
I believe when this all washes out it'll be low dose Metformin that will be accepted for its anti aging properties, not high doses like 1,700 mg per day in an already very insulin sensitive person. As I reach the end of my 30's if and when I start Metformin it won't be more than 500mg per day for me.
Sith 31 Dec 2015
I believe when this all washes out it'll be low dose Metformin that will be accepted for its anti aging properties, not high doses like 1,700 mg per day in an already very insulin sensitive person. As I reach the end of my 30's if and when I start Metformin it won't be more than 500mg per day for me.
Any references for low dose Metformin effects?
noot_in_the_sky 31 Dec 2015
If you want some info about metformin directly related to life extension look here, http://www.lifeexten...137=[magazines]
DbCooper 01 Jan 2016
I believe when this all washes out it'll be low dose Metformin that will be accepted for its anti aging properties, not high doses like 1,700 mg per day in an already very insulin sensitive person. As I reach the end of my 30's if and when I start Metformin it won't be more than 500mg per day for me.
Any references for low dose Metformin effects?
Effects? You're taking more than 3x the amount I said I'd possibly take in the future and your asking me for the possible effects? Seems like you'd know better than I.
Edited by DbCooper, 01 January 2016 - 12:15 AM.
Never_Ending 09 Jan 2016
At 850 mg twice daily wouldn't you be bordering on the upper doses even for patients with diabetes? Just going by this page http://www.drugs.com.../metformin.html
I agree with DbCooper in that if one were to start on Metformin it would make sense to start on low doses (below that of diabetic patients )..
Also at the end of the day Metformin was designed for diabetes and benefits longevity are presumably due to its CR mimicking properties ... I'd hope to see more "expansion" of similar types of chemicals for our purposes in the upcoming years.