LONGECITY

Recenly, I have been using a number of B-complex products, all manufactured by European companies.
I notice that all of them contain amount of niacine /typically 50mg/ that far exceed all other members of the B family, incl. B1, B2, B6, choline, inositol, etc., which are between 1 and 5mg with very few exceptions. This is a bit strange, having also in mind that niacine is almost the only one that can be toxic in high doses. European formulas are also much more conservative /compared to Americans/ in those Bs that are in the mcg range - B12, folic acid.
Seems that Europeans put the stress very much on niacine, while Americans have much more balanced /overdosed?/ B complex products.
Any thoughts on that?

I have found that when I take a good dose (500-1500mg) of Niacinamide, it has it very positive effect. So, I like to take it everytime I eat and take in my supplements.

But really, All the b vitamins are critical. I love them all, and I'd rather not live without them.
Personally I like to take B1 and B12 (the methyl/active form) for overall energy (physical and cognative).

I wonder why B-15 (calcium pangamate) is not in B-complex formulations.

Also, can large doses of niacin cause nerve root inflammation?

it might just be a larger, heavier mollecule... niacin actually isnt essential technically, your body can make it from tryptophan