So what's the best way to enhance bioa...
MrSpud
14 May 2016
This link http://www.counterag...ol Capsules.pdf suggests enteric is the way to go
TA65 claims there's is more bioavailable, but the ingredients declared for both versions don't list anything that would enhance bioavailability. You think they enteric coated the active ingredient powder? Or micronize it or add some undeclared bioavailability enhancer?
Crackaging claims theirs is more bioavailable and they list chitosan as an ingredient that they say helps it get past the stomach acid, and they claim also that Cycloastragenol is fat soluble which limits bioavailability and that either the chitosan or something somehow influences that too.
This link http://www.ncbi.nlm....pubmed/20877137 suggests first pass liver metabolism limits oral bioavailability. What would help overcome that? Would bioperine or some other liver enzyme modifier help?
Like would putting 98% Cycloastragenol in an enteric capsule containing hypromellose phthalate along with an ethoxylated mono and diglyceride wax (solid emulsifier at room temp, but melts at body temp) with a pinch of bioperine (or whatever liver enzyme modifier that would help Cycloastragenol get through the liver) or something along those lines work?
Inquiring minds want to know
TA65 claims there's is more bioavailable, but the ingredients declared for both versions don't list anything that would enhance bioavailability. You think they enteric coated the active ingredient powder? Or micronize it or add some undeclared bioavailability enhancer?
Crackaging claims theirs is more bioavailable and they list chitosan as an ingredient that they say helps it get past the stomach acid, and they claim also that Cycloastragenol is fat soluble which limits bioavailability and that either the chitosan or something somehow influences that too.
This link http://www.ncbi.nlm....pubmed/20877137 suggests first pass liver metabolism limits oral bioavailability. What would help overcome that? Would bioperine or some other liver enzyme modifier help?
Like would putting 98% Cycloastragenol in an enteric capsule containing hypromellose phthalate along with an ethoxylated mono and diglyceride wax (solid emulsifier at room temp, but melts at body temp) with a pinch of bioperine (or whatever liver enzyme modifier that would help Cycloastragenol get through the liver) or something along those lines work?
Inquiring minds want to know
MrSpud
14 May 2016
Here's a link to the Cycloastragenol liver metabolism study in its entirety http://repository.us...95/1/25_477.pdf
They mention cytochrome P450 in the materials and methods section. Does this mean bioperine might help?
They mention cytochrome P450 in the materials and methods section. Does this mean bioperine might help?
MrSpud
14 May 2016
And maybe this kind of emulsifier in there too http://northamerica....o-diglycerides/ they have some that are liquid and some that are solid waxes. You think stuffing in a bit of that and a bit of bioperine along with 10mg 98% Cycloastragenol in one of those enteric hypromellose phthalate hard shell capsules would do the trick?
Any other thoughts or suggestions?
I'm thinking of making some for personal use.
Any other thoughts or suggestions?
I'm thinking of making some for personal use.
Gediminas Jesinas
22 Mar 2018
It is claimed cycloastragenol and astragaloside are soluble in strongly polar solvents such as DMSO, ethanol and so on. There are some claims also about solubility in fat and I wonder if oil could be used to make astragalus root bioavailable source of telomere lenghtening chemicals?
