LONGECITY

Mechanisms of DNA damage by photoexcited 9-methyl-β-carbolines.

 

Reading online experiences for 9-me-bc seem others experience very similar benefits in energy levels, motivation and boost in mood. I am going to try to contact the authors to see if they can give us an even speculative feedback of the possible risks (if any) of 9-me-bc.

A lot of compounds are photosensitizers (e.g. tricyclic antidepressants, St. Johns Wort etc), but the relevancy of this is related to the administered dosages. The unanswered question here is at what dosage does 9-me-bc's DNA damaging photosensitization become harmful. I still haven't come across any anecdotal reports where anyone has noticed increased sunburn from 9-me-bc, but caution is still warranted. I'm avoiding the usage of 9-me-bc during sunny days or will be using a stronger sunscreen.

Edited by ikaros, 22 May 2016 - 06:07 PM.

Good question Strangelove. I'm enjoying the compound for motivation and a small pro-sexual boost. I live and work outdoors in the southwestern US so its hard to completely escape UV exposure. I only use between 1-3mg per day. Hopefully, that is not within range of the UV sensitization effects.

I wouldn't worry too much about the negatives, seems like a fairly benign compound.


"beyond its neuroprotective/neurorestorative and anti-inflammatory effects, 9-me-BC acts as a cognitive enhancer in a hippocampus-dependent task, and that the behavioral effects may be associated with a stimulatory impact on hippocampal dopamine levels and dendritic and synaptic proliferation."

I wouldn't worry too much about the negatives, seems like a fairly benign compound.


"beyond its neuroprotective/neurorestorative and anti-inflammatory effects, 9-me-BC acts as a cognitive enhancer in a hippocampus-dependent task, and that the behavioral effects may be associated with a stimulatory impact on hippocampal dopamine levels and dendritic and synaptic proliferation."

 

Yes I agree, in general not only seems benign, but current research on brain benefits appear very promising. I did not see full benefits until I slowly upped the dose to 50mg/day after one month the effects seem cumulative. I am getting increased energy, boosted mood, far more eager to exercise, more outgoing. I had to increase the dose by 10mg/week as I was getting a little dizzy at first, the same kind when I was using the dopamine precursor l-dopa, now I do not have any issue at all though.

 

I only started researching about any possible risk with long-term use as I am going to include it in my mood boosting combo. The way I see it, if 9-me-bc has the same risk as the other compounds discussed in the study, if it accumulates in the skin and eyes (I doubt it) and at what dose. Ultraviolet light does not go through the skin and only a specific wavelength goes in the retina. Its good to take an extra precaution by wearing our sunglasses, but I ll appreciate any ideas about 9-me-bc pharmacokinetics.

 

As I am using among the largest doses I have seen on line, I ll report back if I get more sensitive to sunburns, and we have many sunny days here during the summer, I go often in the beach too.

I know you posted this a while back, but I thought I'd chime in:

I have done 2x10 day trials of 50mg/day. Both trials were massively successful not only in abolishing my issues with motivation, focus, energy, and mood while trialing, but also in continuing its effects for 2-3 weeks after cessation. 

This is probably the one treatment that I have the hardest time trying to forget, due to its lack of availability, and lack of extended safety profile (If I remember right, you really have to trust the manufacturer or get independent testing done because its easy to mess up during synthesis and make one of the other dangerous carbolines... don't quote me on this as its been a long while since researching).

 

Every few months, I scour the internet looking for new information. I feel as if I'm always looking for the next perfect "fix" for my brain... while pretending that I haven't already found it.

zrbarnes, which is the source you used to trial with?

Any new insights into this? I only found this study, which seems to suggest that the DNA damage is not as bad in cellular DNA compared to cell free DNA, which is normally used when studying this kind of thing.

Edited by Junipersun, 28 May 2017 - 09:25 PM.

There's now even vendors capping this, despite possible risk...

 

http://www.predatorn...harm/9-mbc.html

Any updates on dosage that could lead to DNA damage or UV related cancers?

I've taken it longer term for 3-4 during summer and being outside, didn't even notice any UV sensitivity, despite being very prone to this from other medications like st. johns wort which have only very mild effects in that regard. I can't tell you what to make of this, but  I'm not too worried about the theoretical risks described here. 

Edited by Junipersun, 26 September 2018 - 10:27 AM.

My order of 9-me-bc arrived today and I am just now reading about another potentially toxic effect as well:

https://www.reddit.c...rotoxic_29mebc/

 

Apparently, in addition to the photosensitization issues, it metabolizes into a neurotoxic chemical, which can lead to cognitive decline and other harmful effects.

 

I guess I won't be taking it after all.