Top Lifespan Extending Drugs - Quick Screenshot - Supplements

Anthony_Loera 16 Mar 2017

I just ran into this compiled list of

Top Lifespan Extending Drugs....

I am sharing it because

You guys might like it too!

This is the database for you to browse:

http://genomics.sene...drugs/stats.php

Click to zoom in:

Screen Shot 2017-03-16 at 2.21.50 PM.png 140.92KB 18 downloads

Cheers!

A

Edited by Anthony_Loera, 16 March 2017 - 06:26 PM.

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MikeDC 16 Mar 2017

It is missing the most important one, Niagen.

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albedo 17 Mar 2017

Check out also with this (curated) data base: "...The Geroprotectors.org database comprises more than 250 life-extension experiments in 11 wild-type model organisms (including M. musculus and C. elegans, among others). We gathered data about more than 200 chemicals promoting longevity, including compounds approved for human use. This database integrates information about lifespan-increasing experiments and related compounds, suppression of aging mechanisms, activation of longevity mechanisms and age-related diseases obtained from research papers and databases...."

http://geroprotectors.org/

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albedo 21 Mar 2017

sorry ... post deleted because duplicate

Edited by albedo, 21 March 2017 - 12:57 PM.

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Paul Vrana 17 Jul 2017

It is missing the most important one, Niagen.

I don't know that Niagen is the most important one (although I take it), but this paper should be in that data base:

Science. 2016 Jun 17;352(6292):1436-43. doi: 10.1126/science.aaf2693. Epub 2016 Apr 28.

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice.

Zhang H1, Ryu D1, Wu Y2, Gariani K1, Wang X1, Luan P1, D'Amico D1, Ropelle ER3, Lutolf MP4, Aebersold R5, Schoonjans K6, Menzies KJ7, Auwerx J8.

Author information

Abstract

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD(+)) and its effect on mitochondrial activity as a pivotal switch to modulate muscle SC (MuSC) senescence. Treatment with the NAD(+) precursor nicotinamide riboside (NR) induced the mitochondrial unfolded protein response and synthesis of prohibitin proteins, and this rejuvenated MuSCs in aged mice. NR also prevented MuSC senescence in the mdx (C57BL/10ScSn-Dmd(mdx)/J) mouse model of muscular dystrophy. We furthermore demonstrate that NR delays senescence of neural SCs and melanocyte SCs and increases mouse life span. Strategies that conserve cellular NAD(+) may reprogram dysfunctional SCs and improve life span in mammals.

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MikeDC 17 Jul 2017

We know calorie restriction and exercise extend life span. Some studies are indicating the benefit is from increasing NAD+. They call it the convergence of life extension benefit is NAD+ increase.

"In general, NAD+ levels increase in mammalian tissues in response to energy/nutrient stresses like exercise (Canto et al., 2009; Canto et al., 2010; Costford et al., 2010), fasting (Canto et al., 2010; Rodgers et al., 2005) or calorie restriction (Chen et al., 2008). Accordingly, SIRT1 activity is enhanced by all these conditions."

https://www.ncbi.nlm...12/#!po=6.83060

https://www.ncbi.nlm...estriction nad

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normalizing 22 Jul 2017

life extension in current world means, living longer but more disabled and lonely in a home for elderly. do you really need this? the future is stem cells! renew your body and control the world, not just extend your life, like a retard

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MikeDC 22 Jul 2017

We are talking about extend health span when you are still active until 100 without all the age related illnesses. NAD+ precursors give us hope. It just need more time to be validated in real life.

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normalizing 22 Jul 2017

NAD is not going to make you invincible. you are still getting old and much easier to fall down and break your bones or get infections. also, would NAD fix genetical problems, for example having a gene error for getting asthma or cancer of some type? how would NAD change your genes??

if you think NAD will make you superman at 100, you are out of your mind!

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MikeDC 23 Jul 2017

Nobody said NAD+ is invisible. It is a major aging pathway. If we block this aging pathway by supplementing Niagen, we will stay healthy longer and have less cancer. It may not fix the genes, it could fix issues related to bad genes. Cockayne Syndrome is a good example.

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normalizing 23 Jul 2017

yeah ok thanks mike, you are so informative with lots of references. im falling for it...

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albedo 17 Mar 2018

Check out also with this (curated) data base: "...The Geroprotectors.org database comprises more than 250 life-extension experiments in 11 wild-type model organisms (including M. musculus and C. elegans, among others). We gathered data about more than 200 chemicals promoting longevity, including compounds approved for human use. This database integrates information about lifespan-increasing experiments and related compounds, suppression of aging mechanisms, activation of longevity mechanisms and age-related diseases obtained from research papers and databases...."

http://geroprotectors.org/

To the subject, this recently announced database looks also very relevant:

"...Identifying drugs that could extend lifespan in model organisms has received considerable interest (29). Our new DrugAge database (http://genomics.senescence.info/drugs/) is a curated database of drugs, compounds and supplements with anti-ageing effects that extend longevity in model organisms. Although another database of candidate geroprotectors exists, called Geroprotectors.org (30), DrugAge provides a more comprehensive and systematic dataset of life-extending drugs and compounds (31)...."

https://academic.oup...1/D1083/4599180

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baccheion 28 Mar 2018

Other ideas: iodine protocol, pregnenolone/DHEA, and MSM + silicon (monomethylsilanetriol or bamboo extract) + vitamin C.
Edited by baccheion, 28 March 2018 - 03:53 AM.

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LONGECITY