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Grapefruit and (es)omeprazole

Daniel Cooper's Photo Daniel Cooper 11 Jul 2017

Does anyone know of any harmful interaction between grapefruit and omperazole/esomperazole?

 

I've got some high hemoglobin/hematocrit numbers of so far unknown origin and I'm trying to bring down the hemaocrit whilst minimizing the number of phlebotomies.  There is a paper from 1988 that showed that grapefruit tended to normalize hematocrit numbers (I'd love to have the full text of this paper but can only find an abstract).  

 

Ingestion of grapefruit lowers elevated hematocrits in human subjects  https://www.ncbi.nlm.../pubmed/3243695

 

I take 20mg of esomperazole three times a week to keep some low level GERD in check, and want to make sure I don't get into any issues with interactions.

 

 

 

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