LONGECITY

Hello everyone. I am seeking help.

I have withdrawn from benzos (4mg Klonopin) and opioids (200mg Oxycodone) at the beginning of this year. The benzodiazepine taper took a few months. The Oxycodone was cold turkey.

Anyways, at the moment I suffer from a groin injury for a few weeks now that hurts pretty bad at night which keeps me awake. So I tried to take Oxycodone on occasion. However, suddenly, the Oxycodone causes pain at two spots in my body that have been injured previously. My right wrist and my right shoulder. Everytime I take Oxycodone, those to spots start to hurt. I had a wrist strain a year ago and a shoulder bursitis. Both injuries healed (MRI was done). But still, the Oxycodone causes the same pain in those areas that I had a year ago. Pain in other regions of my body decrease by taking Oxycodone. So it can't be opioid induced hyperalgesia, right?

Now I am wondering if it has to do with the fact that I have withdrawn from the benzos. It seems Oxycodone indirectly inhibits GABA transmission and that opioid induced pain can be caused by NMDA and 5HT-3 receptor overactivity - both receptors go into overdrive during benzodiazepine withdrawal and both can cause pain. I also notice that I get muscle tightness in my neck and jaw after taking Oxycodone. And chest wall rigidity. Something that I never had when I took Oxycodone years ago before I used benzodiazepines. I also get ringing in the ears after taking Oxycodone. But not sure if that's due to the increased neck and jaw tension or Oxycodone itself.

I have read that opioid induced hyperalgesia is pretty common. However, why do only those previously injured spots start to hurt when I take a medication that is supposed to help with pain?

My groin injury is so bad that I need opioids to sleep, but it gives me aching pain in my wrist and shoulder that it is not of a big help.

What's the mechanism behind this phenomen? Could it really be the GABA deficiency and NMDA overactivity I am suffering from due to benzo withdrawal or is there more to it? It also gives me physical anxiety sometimes and a very wired feeling.

Kind regards!

Tricyclic antidepressants can work well for nighttime bone pain. One of my family members had that.

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