Sirtuins sense NAD+, but neither NADH nor...
stefan_001
28 Sep 2017
In particular, we focus on the sirtuin family and assess the current evidence that the sirtuin enzymes sense these dinucleotides and discuss the biological conditions under which this might occur; we conclude that sirtuins sense NAD+, but neither NADH nor the ratio.
http://www.sciencedi...005272817301457
As some of us suspected. More support for NAD+ boosting.
mrkosh1
29 Sep 2017
Interesting. If the SIRT genes do not sense a change in the NAD+ to NADH ratio, what does?
Does PARP notice a change?
Does AMPK notice a change?
Does some other gene notice a change?
MikeDC
30 Sep 2017
Interesting. If the SIRT genes do not sense a change in the NAD+ to NADH ratio, what does?
Does PARP notice a change?
Does AMPK notice a change?
Does some other gene notice a change?
The notion that only the ratio matters is against chemistry and physics. you can have a potential for a reaction, but without reactants nothing will happen.
mrkosh1
30 Sep 2017
I don't think only ratio matters, but I think that it should be able to be sensed by various genetic pathways.
