LONGECITY

I speculated before that NAD+ may up regulate another anti aging gene Klotho. A new human study showed that inflammation reduces klotho expression. We know inflammation down regulate NAD+ and Sirt1. So either NAD+ directly up regulate Klotho or through Sirt1. https://www.ncbi.nlm...i=1&from=klotho

But is there any evidence that increasing NAD+ upregulates Klotho?  

 

 

It is a theory now. We know NMN down regulate NAMPT and inflammation. Lower inflammation should up regulate Kloth. The logic is there. Just need to have direct experimental data.

 

1. That study linked says nothing about NAD+

2. How can a thread starter be off topic with the first post?

We know NAD+ regulate inflammation from other papers posted in other threads. This paper linked inflammation with Klotho.
So inflammation down regulate NAD+, Sirt1, and Klotho. NAD+ down regulate inflammation. There is an positive correlation between NAD+
And Klotho.

I am interested in this because I want to know if NR can take care of Klotho so we don't need to look
For Klotho supplements.

> I am interested in this because I want to know if NR can take care of Klotho so we don't need to look

For Klotho supplements.

 

Are there any klotho supplements?

My opinion is there is no kolotho supplement right now that can go beyond what NR can do. It may never happen if klotho is regulated by NAD+ and Sirt1. Here is the thread on klotho supplements.

http://www.longecity...upplementation/

My opinion is there is no kolotho supplement right now that can go beyond what NR can do. It may never happen if klotho is regulated by NAD+ and Sirt1. Here is the thread on klotho supplements.

http://www.longecity...upplementation/

 

 

With all due respect Mike, you haven't shown that NR upregulates klotho.  What you've shown is that inflammation down regulates klotho and that NR down regulates inflammation to some extent.  I like where your chain of causality is going, but it is a chain and not direct causation.

 

And, what we'd like to see is klotho upregulated to the extent people with favorable genes are upregulated, in other words klotho levels beyond what their genome might normally produce.

 

And any any case, we can make your argument for anything that down regulates inflammation.  Of all the positive things that NR may do, I don't get the impression that it is the strongest anti-inflammatory agent we have on the shelf.

Anything down regulate inflammation without side effects is good for life span. Count all the anti inflammation drugs and see which one doesn't have side effects. More importantly NR increases NAD+ much more than reducing inflammation can do.

Can't argue with the above.