LONGECITY

If you were a 4'10, 97 pound woman, how much NR would you take?  Asking for a friend. 

 

 

Lena,

 

No-one really knows how much the recommended dosage varies between individuals, but most people believe that young people would see much less benefit, while older, sicker people have less NAD+ available and would benefit from a higher dosage.

 

So, bodyweight matter, but age and health probably a lot more so.

Lena,

No-one really knows how much the recommended dosage varies between individuals, but most people believe that young people would see much less benefit, while older, sicker people have less NAD+ available and would benefit from a higher dosage.

So, bodyweight matter, but age and health probably a lot more so.

How young do you think one should begin NR supplementation? When (at which age) does NAD begin to drop?

Lena,

 

No-one really knows how much the recommended dosage varies between individuals, but most people believe that young people would see much less benefit, while older, sicker people have less NAD+ available and would benefit from a higher dosage.

 

So, bodyweight matter, but age and health probably a lot more so.

 

 

Thank you able.   I am 47, so I think I'll stick with the 300mg/day dosing.  

 

Recon, I'm sure I've seen this chart posted here before, but this might help answer your question:

 

https://www.research...-B-FemalesA-NAD

Here the Human Equivalent Dosage (HED) conversions:

https://www.fda.gov/...s/ucm078932.pdf

Lena,

No-one really knows how much the recommended dosage varies between individuals, but most people believe that young people would see much less benefit, while older, sicker people have less NAD+ available and would benefit from a higher dosage.

So, bodyweight matter, but age and health probably a lot more so.

Thank you able. I am 47, so I think I'll stick with the 300mg/day dosing.

Recon, I'm sure I've seen this chart posted here before, but this might help answer your question:

https://www.research...-B-FemalesA-NAD

Thanks! That chart suggests that we'll be having decreasing production of NAD+ since birth. I guess that means it’s be best to take them as soon as possible.

Are you (or is your friend) going to take some others to try and maximise NAD+ production? Nicotinic Acid for the different pathways and possibly resveratrol to up NAMPT?

 

 

Lena,

No-one really knows how much the recommended dosage varies between individuals, but most people believe that young people would see much less benefit, while older, sicker people have less NAD+ available and would benefit from a higher dosage.

So, bodyweight matter, but age and health probably a lot more so.

Thank you able. I am 47, so I think I'll stick with the 300mg/day dosing.

Recon, I'm sure I've seen this chart posted here before, but this might help answer your question:

https://www.research...-B-FemalesA-NAD

Thanks! That chart suggests that we'll be having decreasing production of NAD+ since birth. I guess that means it’s be best to take them as soon as possible.

Are you (or is your friend) going to take some others to try and maximise NAD+ production? Nicotinic Acid for the different pathways and possibly resveratrol to up NAMPT?

 

I take a B-Complex that has Niacin in it.  I was taking 500mg of Niacinamide before learning about NR and am thinking about adding it back in.  

Edited by LenaW, 06 November 2017 - 01:52 PM.

 

That chart suggests that we'll be having decreasing production of NAD+ since birth. I guess that means it’s be best to take them as soon as possible.

Are you (or is your friend) going to take some others to try and maximise NAD+ production? Nicotinic Acid for the different pathways and possibly resveratrol to up NAMPT?

I take a B-Complex that has Niacin in it. I was taking 500mg of Niacinamide before learning about NR and am thinking about adding it back in.

 

There were some talks in some old posts about Niacinamide being an inhibitor to the Sirtuins genes which are the genes you’d want to activate.

Edited by Michael, 13 November 2017 - 08:48 PM.
trim quotes

Yes!  I have read going back several years here and it made my head spin.  Here is the more recent review that has led me to consider adding Niacinamide back in. I was planning on spending some time today on a Pubmed search on the topic.  

 

https://www.ncbi.nlm...pubmed/28417163

 

Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells.

 

Yes! I have read going back several years here and it made my head spin. Here is the more recent review that has led me to consider adding Niacinamide back in. I was planning on spending some time today on a Pubmed search on the topic.

https://www.ncbi.nlm...pubmed/28417163

Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells.

Hwang ES, Song SB.
Cell Mol Life Sci. 2017 Sep;74(18):3347-3362. doi: 10.1007/s00018-017-2527-8. Epub 2017 Apr 17. Review.
PMID:
28417163

That’s really interesting. I’ll take a look at that too!

The posts here are making my head spins as well. I’ve been a lurker years ago when it was all about racetams and intelligence rather than actual longevity.
I’m just back recently and went through NAD posts all the way back to the 2008!