LONGECITY

Took me years to figure this stuff out but here we go:

Potassium iodide / thyroid hormones

Keto diet / Fasting

 

Keto and fasting works through the same pathways so either should suffice. Thyroid hormones and potassium iodide also work through the same pathways.

Metergoline.

Why you wanna lower serotonin?

https://www.medicaln...cles/322263.php

The neurotransmitter serotonin is linked to the control of mood, though it also helps to regulate various other functions, such as sleep and sexual desire. New research has uncovered another role played by serotonin: boosting learning speed

Because it causes chronic fatigue, anxiety, irritability and a whole host of other issues, some of which but not all are caused specifically by the 5ht2a receptor.

 

Because it causes chronic fatigue, anxiety, irritability and a whole host of other issues, some of which but not all are caused specifically by the 5ht2a receptor.

So one would want lower 5ht2a activation? Don’t all ssri’s increase 5ht2a? And if 5ht2a causes anxiety why would an ssri be prescribed for it if it further increases it.

Another poster spreading some ABC-neuroscience bullshit . "This receptor is bad and this one is good". It doesn't work that way. 5-HT2A activation is important for various things like inner confidence, hedonia and creativity. Sure, antagonizing it relieves certain states such as melancholic depression. 5-HT2A actually downregulates from both agonism and antagonism. SSRIs downregulate the receptor long term which is considered one of their therapeutic effects.

Re-read. Never did I say the receptor is bad. We have receptors for a reason. But I am susceptible to 5ht2a overactivity as are many Europeans due to genetics. This receptor is another one whose polymorphisms (increased activity) increases iq slightly.

Re-read. Never did I say the receptor is bad. We have receptors for a reason. But I am susceptible to 5ht2a overactivity as are many Europeans due to genetics. This receptor is another one whose polymorphisms (increased activity) increases iq slightly.

From looking at my polymorphisms It seems I benefit from a reduction of 5ht2a with an increase in 5ht1a and a balance of 5ht2c. I use Lexapro and recently added Abilify which is perfect since it’s a 5ht2a partial antagonist and 5ht1a partial agonist. So I just have to tackle 5ht2c which I’m thinking higher doses of Inositol may help. Possibly Agomelatine since it’s an antagonist at 5ht2c but i’ve read a few negative things recently about it on ncbi.
Edited by John250, 03 July 2018 - 04:34 PM.

So you want to lower serotonin concentrations in the whole brain?

 

If you have a hypoacetylated H4K12 lysine because of a deprivated childhood, you will have increased SERT. Pharmaceutical SSRis (and Kanna) can temporarily lower the amount of SERT, but with a stronger HDACi you can acetylate H4K12, which normalizes the amount of SERT, causing a slower uptake of serotonin. In the gut, this may abolish IBS.