Curcumin as a CBD modulator(short term) an...
Ruth
14 Nov 2018
https://www.scienced...924977X16320120
These subtle effects were found at a 1:1 CBD:THC dose ratio but were not accentuated by a 5:1 dose ratio. CBD did not alter the trajectory of enduring THC-induced anxiety nor tolerance to the pharmacological effects of THC. There was no evidence of CBD potentiating the behavioural effects of THC. However we demonstrated for the first time that repeated co-administration of CBD and THC increased histone 3 acetylation (H3K9/14ac) in the VTA and ΔFosB expression in the nucleus accumbens. These changes suggest that while CBD may have protective effects acutely, its long-term molecular actions on the brain are more complex and may be supradditive.
Previous article in issue
"We thus hypothesized that the administration of HAT (histone acetyltransferase) inhibitors could
be beneficial for MDS/AML pa- tients with reduced Gfi1 expression as it could reverse the
increased acetylation of H3K9. Curcumin is a HAT inhibitor which is used as a spice "
https://www.exphem.o...0439-9/abstract
These subtle effects were found at a 1:1 CBD:THC dose ratio but were not accentuated by a 5:1 dose ratio. CBD did not alter the trajectory of enduring THC-induced anxiety nor tolerance to the pharmacological effects of THC. There was no evidence of CBD potentiating the behavioural effects of THC. However we demonstrated for the first time that repeated co-administration of CBD and THC increased histone 3 acetylation (H3K9/14ac) in the VTA and ΔFosB expression in the nucleus accumbens. These changes suggest that while CBD may have protective effects acutely, its long-term molecular actions on the brain are more complex and may be supradditive.
Previous article in issue
"We thus hypothesized that the administration of HAT (histone acetyltransferase) inhibitors could
be beneficial for MDS/AML pa- tients with reduced Gfi1 expression as it could reverse the
increased acetylation of H3K9. Curcumin is a HAT inhibitor which is used as a spice "
https://www.exphem.o...0439-9/abstract
gamesguru
15 Nov 2018
These subtle effects were found at a 1:1 CBD:THC dose ratio but were not accentuated by a 5:1 dose ratio. CBD did not alter the trajectory of enduring THC-induced anxiety nor tolerance to the pharmacological effects of THC.
However we demonstrated for the first time that repeated co-administration of CBD and THC increased histone 3 acetylation (H3K9/14ac) in the VTA and ΔFosB expression in the nucleus accumbens. These changes suggest that while CBD may have protective effects acutely, its long-term molecular actions on the brain are more complex and may be supradditive.
1:1 is not enough of a ratio, but 5:1 is more than recreational users would be willing to settle on
the bits about FosB and supraadditive effects are concerning. based on that alone we would expect increased addictive qualities, but really we see the opposite for a predominant reason
there are lots of HAT inhibitors out there besides turmeric, I'm not sure there is too much clinical relevance in this mechanism anyways. if it were we would find effective medicines in many, many unsuspecting places
