“LDN” (Naltrexone) type of drug for testos...
Seganfredo
25 Feb 2019
In my mind I’ve been tinkering with substance resistance and sensitization, Mithridatism, Paracelsus’ principles like “Sola dosis facit venenum” (the dose makes the poison), “similia similibus curentur” (like cures like), the claims of pseudosciences like isopathy/homeopathy, and stuff like it for many years. I still don't have a strong enough grasp of these subjects, but medschool running smoothly I'll soon know much better how it all connects and have a more educated, broader perspective.
Now, since I found out about the wonders of Low Dose Naltrexone-LDN, even touted by many as the greatest medical discovery of the last century, and started taking it, I’ve been asking myself if a somewhat analogous mechanism can be brought forth to heighten testosterone and also cognitive function/work efficiency/mood through low-dose antagonists that metabolize quickly. Here's LDN's mechanism, basically: opioid receptor blockade by LDN provokes a compensatory elevation in endogenous opioids and opioid receptors that can function after LDN is no longer available (therefore causing an immunioregulatory effect, as endorphins have this role in the body.) Through its mechanism I calculated that LDN may "erase" acquired drug resistance to (meth)amphetamines and counter most of its negative effects and, lo and behold, scientists in Scandinavia are studying exactly this, with quite a good level of success.
In short, I'm looking for some substance that in low doses may provoke compensatory elevation of endogenous testosterone and/or one of the many endogenous substances that regulate cognition and other higher executive functions (elevating androgen/substance receptors & production).
Any useful ideas, experiences, & comments will be appreciated.
Edited by Seganfredo, 25 February 2019 - 07:26 AM.
micro2000
28 Feb 2019
John250
02 Mar 2019
Low dose letrozole will increase testosterone levels by reducing estrogen levels. All you need is 0.125-0.25mg per day.
It will destroy estrogen though, can induce Hypoestrogenism. Bloodwork is a must. I’d opt for another AI like Aromasin or Arimidex.
livingguy
10 Apr 2019
I don't think anti aromatisation is the way to go for raising testosterone, given Estrogen's role in bone density, sexual function, cognitive function and heart disease prevention.
BasicBiO
19 Apr 2019
I don't think anti aromatisation is the way to go for raising testosterone, given Estrogen's role in bone density, sexual function, cognitive function and heart disease prevention.
Yes but as a matter of perspective, all things in moderation. Letrozole will absolutely crush E levels even at a low dose, but other AI's like arimidex or exemestane are easier to dial in the dose and lower E to a suitable level. Done in concert with bloodwork, of course.
turchin
10 May 2019
Low dose (2.5 mg) menantine every three days - good for mood and cognition.
