LONGECITY

Anybody no when the Nuchido product is going to be for sale ? I have been waiting for it to come out scents the middle of May .

They had a limited small-run supply at the conference. They are now taking orders on their website, so it must be coming out soon.

Hopefully it's not too late ...  but if you could ask around, or specifically Chromadex (are they there?) about the potential for NRH as it seems they hold some patents related to it. It sounds like a highly effective NAD+ precursor that could be a good 2nd generation replacement to NR. Thanks.

Good questions. I will see if I can get some answers from some of the NAD specialists at the conference.

 

For #2, I suspect the mice die from causes unrelated to the NAD+ boosters, or many are possibly sacrificed at the end of the experiment.

 

Since you brought up this question, I will share an interview with Dr. Nichola Conlon who founded the company Nuchido. Instead of focusing on the precursors, they used a systems pharmacology approach to identify compounds that could rescue or re-invigorate the NAD+ salvage/recycling pathways that fail in older cells.

 

With their cocktail, they were able to raise cellular NAD+ by 70%, almost as much as NR or NMN (which raised cellular NAD+ by 90% in their test subjects). So their product raises cellular NAD+ WITHOUT precursors. When they added a precursor (NAM) with their cocktail, cellular NAD+ went up by 862%. Their product will be on the market soon.

 

The interview with the founder is on the podcast page now.

An interesting approach that  I hope pans out. I would caution though that the 862% claim is misleading at best.

At the party Friday night, I  asked Dr Conlon about the study and she told me directly that the 48 yr old woman was actually one of 4 in that study.

The 4 people tested showed an average of 240% increase.  So it seems there was huge variability.  

She did mention in her talk that the 862% was 1 person, and she didn't have time to go over results of others, but that seems something they  should do a better job of explaining.

240% is still very good,  and if their studies going on now show similar results they will have a winner.  But its not really 862%.

The people behind qalytude are at RAADfest. They are developing a network of doctors who are sympathetic toward treating aging as a disease and are motivated to get supplements and pharmaceuticals into the hands of bio-hackers.

Impressively, the project/business is entirely self-funded thus far.

Hopefully it's not too late ...  but if you could ask around, or specifically Chromadex (are they there?) about the potential for NRH as it seems they hold some patents related to it. It sounds like a highly effective NAD+ precursor that could be a good 2nd generation replacement to NR. Thanks.

I was unable to get to them and investigate this question

An interesting approach that  I hope pans out. I would caution though that the 862% claim is misleading at best.

 

At the party Friday night, I  asked Dr Conlon about the study and she told me directly that the 48 yr old woman was actually one of 4 in that study.

 

The 4 people tested showed an average of 240% increase.  So it seems there was huge variability.  

 

She did mention in her talk that the 862% was 1 person, and she didn't have time to go over results of others, but that seems something they  should do a better job of explaining.

 

240% is still very good,  and if their studies going on now show similar results they will have a winner.  But its not really 862%.

Definitely a small sample size. As we see with other supplements and supplement combos, effects vary from individual to individual.

The 4 people tested showed an average of 240% increase.
... the 862% was 1 person...

240% is still very good

If the 862% person was part of that group of 4, it means the other three people had an average increase of only 33%.

Yes, I read that. (So they mention 242% i.s.o. 240%.)
It would be interesting to know how they arrived at that 242% number. If it came from one person with an 862% increase and three persons with only a 35% increase, then the 242% number looks misleading to me.
Still, I like their approach and I ordered their product to try it for myself.

How will you rate the increase in NAD +?

No idea yet. Maybe I will notice something, maybe I won't. I take some NMN now, but I don't notice anything. Still, I hope it does something good and I keep taking it.

 

Yes, I read that. (So they mention 242% i.s.o. 240%.)

It would be interesting to know how they arrived at that 242% number. If it came from one person with an 862% increase and three persons with only a 35% increase, then the 242% number looks misleading to me.

Still, I like their approach and I ordered their product to try it for myself.

 

With only 4 test subjects, sounds like they have a marketing plan to make news (and money), by stretching "results" to cover for next to nothing.

Did you discuss the results of the TRIIM study at RAADfest 2019?

I talked to Dr. Fahy briefly about it. I posted our discussion here. Basically I wanted to ask him why haven't we seen "age reversal" previously with rhGH supplementation. He said that the addition of the the insulin pathway modulators must have been the key, but he wasn't 100% sure.

With only 4 test subjects, sounds like they have a marketing plan to make news (and money), by stretching "results" to cover for next to nothing.

That would be a little deceptive to highlight a big improvement of NAD+ in one person, if the other 3 subjects were not improved much at all.

I guess it’s too mean or impolite to ask Ray Kurzweil straight up how he’s evidently cured male pattern hair loss? A few years ago he looked like he was near bald. Now?

I mean, it looks to me like it's a toupée.

One of the more spectacular presentations was from Dr. Nicola Di Valerio of West Sussex Hospitals.

Instead of injecting stem cells into degenerative joints - which has not shown much success - he has developed a biomaterial impregnated with Pdrn (polydeoxyribonucleotides), growth factors, and HSP (heat shock proteins). The biomaterial is surgically inserted into the bad joint and it stimulates endogenous stem cells. The stem cells then help repair the damaged joint in situ.

He claimed the procedure had been 80% effective thus far, with patients ending up with less pain and more mobility. He displayed several xrays of the repaired joints and it was clear that some of the patients had regrown cartilage. Their joints looked "repaired". It was pretty amazing (for a few of the patients).

Not FDA approved yet.

It is something that is needed in rejuvenation - repair of mechanical damage. Your other tissues could be in great shape but if your joints are damaged, they will still prevent you from living life to its fullest.

Here is a youtube interview with the Dr. Valerio (sorry, I was unable to get an interview)

Here is a paper referencing the procedure.

I spoke to a couple other people involved in systems pharmacology and they said there might be something to Nuchido's claims.

There's certainly a solid systems pharmacology rationale for Nuchido's formulation (hit the various mechanisms that deplete NAD+ rather than only providing precursors to synthesize it). However, that's far different from it actually working. They presented at Undoing Aging in 2018, making bold claims from scant/no evidence — and are still making the same bold claims on what is essentially the same scant/no evidence, plus a claim (from n=1) about SIRT1 protein levels that makes no biochemical sense, rather than having taken their initial results as the basis for running a decent-sized trial to get reliable data before selling and hyping the product.

Even looking at the formula (thanks for finally letting us see this, Mind, since the company so far has not), it's not at all clear that it's theoretically well-formulated, since several of the key ingredients have only ever been shown to hit the relevant mechanisms in vitro, or (in the case of lipoic acid) is knwon to affect oxidative stress in rodents and diabetic humans, but not in non-diabetic humans (except during exercise, where lipoic acid is counterproductive precisely because it quenches the burst of free radicals that signal the cell to initiate adaptive responses to overload). It also doesn't do anything about NAM methylation.

Dr. Dean Ward from IAS (link) gave a presentation at RAADfest. He was touting the benefits of deprenyl as a life extending substance. He had a lot of data showing lifespan extension and health improvement in animal models. In fact he claimed that deprenyl extended the lives of every species tested, which seems rather remarkable, because this has been debated through the years here in the LongeCity forum...even as far back as 2005, 

Dr. Ward made it seem like a miracle drug that everyone should be taking. I wonder why more people do not.

You can stream all of the presentations from RAADfest. $195 for the stream.

Here is the video of Bill Faloon describing recent progress in rejuvenation strategies and introducing the Vitality in Aging study.

https://www.youtube....eature=youtu.be

Dr. Ross Duncan of Kimera Labs presented at RAADfest about exosomes.

This topic has garnered increased attention here at LongeCity in the last couple of years.

https://www.longecit...-aging-in-mice/

https://www.longecit...n-in-aged-skin/

https://www.longecit...somes-in-aging/

Dr. Duncan speculated that perhaps we do not need stem cells for rejuvenation of damaged tissues, but only the exosomes from young cells. He claimed that exosomes might eventually be heralded as the "penicillin of our day".

He promoted his company by showing examples of how they verify the presence of exosomes using what I think was a proprietary device called the "nanosight microscope".

Outside of Dr. Duncan's presentation, it was noticeable that exosomes are an up-and-coming trend in rejuvenation therapies (even if speculative and not completely "proven" yet) by the presence of 2 or 3 different exosome-producing companies at RAADfest.

Dr. Ross Duncan of Kimera Labs presented at RAADfest about exosomes.

This topic has garnered increased attention here at LongeCity in the last couple of years.

https://www.longecit...-aging-in-mice/

https://www.longecit...n-in-aged-skin/

https://www.longecit...somes-in-aging/

Dr. Duncan speculated that perhaps we do not need stem cells for rejuvenation of damaged tissues, but only the exosomes from young cells. He claimed that exosomes miight eventually be heralded as the "penicillin of our day".

He promoted his company by showing examples of how they verify the presence of exosomes using what I think was a propretary device called the "nanosight microscope".

Outside of Dr. Duncan's presentation, it was noticeable that exosomes are an up-and-coming trend in rejuvenation therapies (even if speculative and not completely "proven" yet) by the presence of 2 or 3 different exosome-producing companies at RAADfest.

Some of you might remember the fellow who won a body improvement contest - he became somewhat of a sex symbol, imo. Dr. Jeffry Life was at RAADfest 2019. I asked him about his journey from being unhealthy in his late 50s to being fit and more healthy a couple decades later. Since he was at RAADfest, I expected he might be on more of a rejuvenation bandwagon. From the interview you will find that he has stuck with more natural approaches thus far. The podcast is now live.

Mind, here is the evidence that my microRNA concept is correct:

https://phys.org/new...-role-aging.amp

Thanks for the update. I will check it out.

Some of you might remember the fellow who won a body improvement contest - he became somewhat of a sex symbol, imo. Dr. Jeffry Life was at RAADfest 2019. I asked him about his journey from being unhealthy in his late 50s to being fit and more healthy a couple decades later. Since he was at RAADfest, I expected he might be on more of a rejuvenation bandwagon. From the interview you will find that he has stuck with more natural approaches thus far. The podcast is now live.

I clicked on the podcast link but it doesn't load.

Mind, I'm not sure what you mean be "natural approaches". What I see here (looking at the thumbnail photo) is a man who has a marvelous physique and is clearly on a some sort of performance enhancement substance. I haven't heard the podcast interview but I'm guessing he talks a lot about how he eats clean, exercises, etc but never mentions a word about his gynecomastia issue. Does he mention anything about performance enhancing substances? Test? Hgh? Peptides? Not to diminish his achievement, he loos terrific for any age, just wondering if he was transparent in the interview.

I clicked on the podcast link but it doesn't load.

 

Mind, I'm not sure what you mean be "natural approaches". What I see here (looking at the thumbnail photo) is a man who has a marvelous physique and is clearly on a some sort of performance enhancement substance. I haven't heard the podcast interview but I'm guessing he talks a lot about how he eats clean, exercises, etc but never mentions a word about his gynecomastia issue. Does he mention anything about performance enhancing substances? Test? Hgh? Peptides? Not to diminish his achievement, he loos terrific for any age, just wondering if he was transparent in the interview.

Try this link.

As you can hear, he just pushed his book(s) - nothing of substance shared beside being on a LCHF/keto diet.

He is definitely on all of the mentioned things and then some - no one in his 70s can achieve this otherwise.

Sorry, I forgot the link to the podcast page: https://www.longecity.org/podcast/

When he got is great physique (a few years ago) he was working with a company/product called Cenegenix. There may have been some testosterone boosting stuff in that formulation.

Mind,I look to this website as a source of generally reliable information to be considered,  particularly regarding moderators. You as a moderator can't truly believe that the so called T-boosters in Cenegenix is responsible for this mans physique.. can you?? It's akin to attributing the physique of Arnold Schwarzenegger to Joe Weider's muscle builder shakes.