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Natural anticholinergics?

choline

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3 replies to this topic

#1 reckful

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Posted 06 December 2020 - 10:22 PM


Is there anything that can help lower choline levels in the body? I've read Piracetam helps burn it up, but I can't find it in stock anywhere.



#2 gamesguru

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Posted 07 December 2020 - 01:10 AM

There aren't any readily available inhibitors of Choline acetyltransferase, and I don't know any tricks to enhance breakdown, vesicular uptake or diffusion. Piracetam's MOA is still hotly contested

 

One solution is to avoid eggs and high choline foods, and only consume modest amounts of AChE inhibitors (tea, ginseng, bacopa).

 

I'm sure other things might interact—magnesium[1], creatine, ascorbic acid[2]—but to what extent? Why not just practice the simple solution first? Tone down overall choline intake, then start to investigate flavonoids and other dietary factors at the alpha-7 or other muscarinic sites of interest. There are lots of ways to enhance spatial memory and the likes while maintaining low choline levels.


Edited by gamesguru, 07 December 2020 - 01:11 AM.

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#3 elc202

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Posted 07 December 2020 - 04:42 AM

This article claims that Forskolin boosts Acetylcholinesterase, which results in a reduced Acetylcholine level in the brain. I don't know if it is a trustworthy website.


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#4 Daniel Cooper

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Posted 07 December 2020 - 09:48 PM

I don't have any great answers for you either. The only ones I know about are belladonna and mandrake. Both have similar anticholinergenic activity due to the fact they contain alkaloids like atropine and scopolamine which also make them somewhat dangerous to play around with.  They don't call it Deadly Nightshade for nothing.







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