MitoQ might be an ideal antioxidant
hormoneman 21 Apr 2007
curious_sle 21 Apr 2007
hormoneman 21 Apr 2007
neogenic 21 Apr 2007
http://www.groupsrv....ost-910070.html
When doing a search its listed as MitoQ and MitoQ10
neogenic 21 Apr 2007
I think I found the same page. I had found it once before as they stock Spin Traps, MitoQ, TransResveratrol, BPAP, Ethylvanillin ethylenediimato manganese, and all the forms of B-6 (pyridoxal, etc.). Are we not allowed to state the links of such sites here due to their gray status? They do have disclaimers, that seem to bypass some of those issues. I'll list it if it is ok.There is an easy way to get it - I know of a least 1 site that sells it - I've e-mailed them for a price quote
niner 21 Apr 2007
proteomist 22 Apr 2007
proteomist 23 Apr 2007
edward 23 Apr 2007
http://www.drugdiges...quinone,00.html
neogenic 23 Apr 2007
proteomist 23 Apr 2007
The site I have, I believe is a bit more reputable. PM me, I guess, if I can't post it.
kenj 23 Apr 2007
edward 23 Apr 2007
http://www.drugdiges...quinone,00.html
proteomist 23 Apr 2007
Again, it's just plain old CoQ10! Or am I missing something. Take a look at this link.
http://www.drugdiges...quinone,00.html
curious_sle 23 Apr 2007
CoQ10. "
http://groups.google...b981a52b7a0c9b6
edward 23 Apr 2007
Mitoquinone
Scientific Name: Coenzyme Q-10
Other Names: Co Q 10, Q 10, Ubidecarenone, Ubiquinone, Vitamin Q
What side effects should I watch for?
No serious side effects have been associated with taking coenzyme Q-10, although some individuals have reported minor gastrointestinal disturbances such as diarrhea, indigestion, and nausea while taking it.
proteomist 23 Apr 2007
I agree, the site you linked to does not describe MitoQ, but uses the name misleadingly.
Separate from that, the Vitaspace page claims to offer actual MitoQ but does not provide details.
proteomist 23 Apr 2007
"MitoQ is in fact an attachment of TPP to the tail of idebenone, not to
CoQ10. "
http://groups.google...b981a52b7a0c9b6
neogenic 23 Apr 2007
That's the one.It's listed at Vitaspace. This supplier is mentioned in the supplement supplier thread also.
proteomist 11 May 2007
Synthesis of MitoQ:
Triphenylphosphine was dissolved in 48% HBr by heating to 70C for five minutes. The mixture was allowed to cool, then extracted with methylene chloride, dried and concentrated to give triphenylphosphonium hydrobromide as a pink foam in ~70% yield.
To 16 mmol triphenylphosphonium bromide was added one mole equivalent of idebenone and one equivalent of triphenylphosphine, without solvent. The mixture was sealed in a round-bottom flask with a septum secured with a zip-tie, and stirred at 70C in an oil bath. The solids rapidly melted to give an orange oil which darkened over 22hrs to a green-black glass.
The product was washed three times with 200 ml of ethyl acetate at 70C for 5', which removed the triphenylphosphonium oxide side-product as well as residual idebenone. The remaining brown tar was washed with 200ml of water containing 2 ml of 48% HBr for 10' at 60C. This removes methyl triphenylphosphine formed by an ether cleavage side reaction. The water was decanted and the remaining dark red oil (MitoQ) was collected and analyzed to confirm identity. Total yield ~70% or 7 grams.
maxwatt 11 May 2007
At the risk of getting a ton of people asking me for this compound, I will mention that I successfully made a batch of MitoQ this week by following the protocol described in the Antipodean patent disclosure. Since we have a lot of technical sorts here who might have the means and desire to do the same, I'll share some details. And no, you can't have any, unless you've got a legitimate research use or some other really good reason you can convince me of [tung]. And no, I'm not selling it.
Synthesis of MitoQ:
.....
Brilliant.
PWAIN 11 May 2007
Have you tried it and did you notice any effect?
paragon 11 May 2007
PWAIN 11 May 2007
If you look at the pricing of MitoQ, 7 grams is a bucket load. I imagine 20 to 50mg per day would be a starting dose. That is between 140 and 350 days supply.
proteomist 11 May 2007
As to the seven grams, this was a pilot run. I'll probably scale ten fold to lay in as much as I might need, ever [lol].The published synthesis in the papers is a major P.I.T.A. compared to the one I did from their patent. This one's actually really easy with the right tools. I'm more or less limited by handling capacity and other more pressing demands on my time as to how much I can make, but if you had a decent basic lab I don't think it would be hard to make a few kilos a week, one person.
Well done, I knew you would do it.
Have you tried it and did you notice any effect?