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RNA therapy?

browser's Photo browser 04 Dec 2007

Who said there's an RNA deficiency in the first place? Why is there no research about this at all?
What prompted anyone to inject themselves with RNA initially? What form is the RNA in the injection?

Benjamin Frank, M.D. considered RNA to be a vitamin. Considering the Mediterranean Diet high in fish intake and our long use of fermented products (the Pilgrams finished their journey because the ran out of beer) it might just be.
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browser's Photo browser 04 Dec 2007

Who said there's an RNA deficiency in the first place? Why is there no research about this at all?
What prompted anyone to inject themselves with RNA initially? What form is the RNA in the injection?


This research may be related. RNA contains uridine.

Brain Res. 2007 Nov 28;1182:50-9.
Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus.
Sakamoto T, Cansev M, Wurtman RJ.
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, is an essential component of membrane phosphatides and has been implicated in cognitive functions. Low levels of circulating or brain DHA are associated with various neurocognitive disorders including Alzheimer's disease (AD), while laboratory animals, including animal models of AD, can exhibit improved cognitive ability with a diet enriched in DHA. Various cellular mechanisms have been proposed for DHA's behavioral effects, including increases in cellular membrane fluidity, promotion of neurite extension and inhibition of apoptosis. However, there is little direct evidence that DHA affects synaptic structure in living animals. Here we show that oral supplementation with DHA substantially increases the number of dendritic spines in adult gerbil hippocampus, particularly when animals are co-supplemented with a uridine source, uridine-5'-monophosphate (UMP), which increases brain levels of the rate-limiting phosphatide precursor CTP. The increase in dendritic spines (>30%) is accompanied by parallel increases in membrane phosphatides and in pre- and post-synaptic proteins within the hippocampus. Hence, oral DHA may promote neuronal membrane synthesis to increase the number of synapses, particularly when co-administered with UMP. Our findings provide a possible explanation for the effects of DHA on behavior and also suggest a strategy to treat cognitive disorders resulting from synapse loss.

PMID: 17950710

The more RNA components you can supply, the less the body has to recycle its own, thereby saving energy and spurring cell growth.
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Spiral Architect's Photo Spiral Architect 04 Dec 2007

Who said there's an RNA deficiency in the first place? Why is there no research about this at all?
What prompted anyone to inject themselves with RNA initially? What form is the RNA in the injection?

Benjamin Frank, M.D. considered RNA to be a vitamin. Considering the Mediterranean Diet high in fish intake and our long use of fermented products (the Pilgrams finished their journey because the ran out of beer) it might just be.


Is this an answer to my questions? I'm not sure what you're trying to say here.
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