Res and Biological activities
Hedgehog
29 Dec 2007
I was reading about some of these SIRT1 activators and found the myricetin is the most potent at inhibiting kinases.
Relationship between flavonoid structure and inhibition ofphosphatidylinositol 3-kinase: a comparison with tyrosine kinase andprotein kinase C inhibition.
I also found this in another article. You guy's have probably already talked about this but I hadn't seen it.
Relationship between flavonoid structure and inhibition ofphosphatidylinositol 3-kinase: a comparison with tyrosine kinase andprotein kinase C inhibition.
I also found this in another article. You guy's have probably already talked about this but I hadn't seen it.
niner
30 Dec 2007
Prevention of LDL peroxidation promotes atherosclerosis?
I get the impression that the concentrations cited are not EC50s or the like... just whatever was used in the experiment. Most of us are unlikely to see plasma concentrations of free resveratrol greater than low single digit micromolar, although questions remain regarding possible concentrating mechanisms.
I get the impression that the concentrations cited are not EC50s or the like... just whatever was used in the experiment. Most of us are unlikely to see plasma concentrations of free resveratrol greater than low single digit micromolar, although questions remain regarding possible concentrating mechanisms.
Hedgehog
02 Jan 2008
Prevention of LDL peroxidation promotes atherosclerosis?
I get the impression that the concentrations cited are not EC50s or the like... just whatever was used in the experiment. Most of us are unlikely to see plasma concentrations of free resveratrol greater than low single digit micromolar, although questions remain regarding possible concentrating mechanisms.
I think it was whatever the experiment was using. With Regards to the LDL and HDL. It appears that Res binds better with LDL(Bad) thus protecting against oxidation. Res binds to HDL(good), but not with the same affinity as LDL. I agree it would hard to achieve those concentrations.
niner
03 Jan 2008
I'm still confused about how prevention of LDL peroxidation would promote atherosclerosis. I thought that lipid peroxidation was a bad thing...Prevention of LDL peroxidation promotes atherosclerosis?
I get the impression that the concentrations cited are not EC50s or the like... just whatever was used in the experiment. Most of us are unlikely to see plasma concentrations of free resveratrol greater than low single digit micromolar, although questions remain regarding possible concentrating mechanisms.
I think it was whatever the experiment was using. With Regards to the LDL and HDL. It appears that Res binds better with LDL(Bad) thus protecting against oxidation. Res binds to HDL(good), but not with the same affinity as LDL. I agree it would hard to achieve those concentrations.
