LONGECITY

will cerebroylsin actually "heal" or "repair" the brain?

or is cerebroylsin similar to caffeine and addreall which gives a temporary "boost", if you will, to overall brain function
Edited by crusader, 20 January 2013 - 08:18 PM.

According to the experiments performed on rats with learning disabilities and patients with Alzheimer’s disease, the beneficial effects of Cerebrolysin lasted for a number of months after the treatment was completed, but after a point tended to decline towards baseline. e.g.¹


However, for those of us who are lucky enough not to be suffering from any degenerative disease, we might indeed expect the positive changes which Cere could help us effect to be permanent, since the neurotrophic effects of Cere may, in effect, be helping us to build a new brain.

Off topic from the above, but this paper, published a couple of months ago, looks intriguing:
https://www.ncbi.nlm...pubmed/22882711

Cerebrolysin administration reduces oxidative stress-induced apoptosis in lymphocytes from healthy individuals
Cerebrolysin is the only drug available for clinical use containing active fragments of some important neurotrophic factors obtained from purified porcine brain proteins, which has long been used for the treatment of dementia and stroke sequels. Cerebrolysin has growth factor-like activities and promotes neuronal survival and sprouting, however, its molecular mechanism still needs to be determined. It has been shown that Cerebrolysin may interact with proteolytic pathways linked to apoptosis. Administration of Cerebrolysin significantly reduces the number of apoptotic neurons after glutamate exposure. Furthermore, it has been reported that Cerebrolysin inhibits free radicals formation and lipid peroxidation. In vitro we evaluated the protective effects of Cerebrolysin towards spontaneous and induced apoptotic death in cells from healthy individuals. Peripheral blood lymphocytes (PBLs) from 10 individuals were used as cell model; 2-deoxy-D-ribose (dRib), a highly reducing sugar, was used as paradigm pro-apoptotic stimulus. Apoptosis was analysed using flow cytometry and fluorescence microscopy. Our results showed that Cerebrolysin significantly reduced the number of apoptotic PBLs after dRib treatment, although it had no significative effects on cells cultured in standard conditions. Our work showed a protective effect of Cerebrolysin on oxidative stress-induced apoptosis and suggested that PBLs can be used as an easy obtainable and handy cell model to verify Cerebrolysin effects in neurodegenerative pathologies.

^{1 Ruether E, Husmann R, Kinzler E, Diabl E, Klingler D, Spatt J, Ritter R, Schmidt R, Taneri Z, Winterer W, Koper D, Kasper S, Rainer M and Moessler H (2001). A 28-week, double-blind, placebo-controlled study with Cerebrolysin in patients with mild to moderate Alzheimer’s disease. Int Clin Psychopharmacol. 16:253-63. http://www.ncbi.nlm....t_uids=11552768
fulltext here http://www.renacenz....arez I 2006.pdf}
Edited by friable vitreous carapace, 20 January 2013 - 08:58 PM.

Rat neurology is more sub-optimal than ours', leaving more room for exaggerated gains. Confounding effects include that less marked relative cognitive decline they experience compared to humans. The net effect is ambiguous.

However, these results are somewhat reassuring.

I remind folks that the Dual N-Back protocol is an easy way to test their gains vis-a-vis working memory (and potentially fluid intelligence). Even unblinded quantitative results under repeatable conditions are valuable, under these circumstances.

The least I would ask of some of you with prior N-Back training is that you post your results post-Cerebrolysin use (i.e. more than one week) with at least one week of dosed DNB data to contrast your results.

Negative / Neutral results are valuable, so do not shy away from posting unremarkable results if that's what you find.

Considering Cerebrolysin is a neurotrophic, I think it's more likely that practing Dual-N-Back on it causes working memory increases than that it measures improvements that were already available in the background before starting the game.

Which only makes it more important to do these tests, for the user as well as the curious audience.

Correct, there are potential complementary gains to be had from simply performing this exercise.

Did cerebrolysin increase the power of your emotions(did you feel emotions more consistently and/or have deeper emotions) while on this?
This isn't really something I can find in a medical paper.

Did cerebrolysin increase the power of your emotions(did you feel emotions more consistently and/or have deeper emotions) while on this?
This isn't really something I can find in a medical paper.

I'm not sure if you are replying to someone or what, but it has helped me in this area.

What people need to understand is that CB is not a drug in the way people think of them. It simply supplies the brain with the building blocks it needs to repair ITSELF. So, trying to come up with a definitive list of things it help would be futile.

I have no doubt that it is effective for ANY non-inborn brain issue.

Did cerebrolysin increase the power of your emotions(did you feel emotions more consistently and/or have deeper emotions) while on this?
This isn't really something I can find in a medical paper.

I'm not sure if you are replying to someone or what, but it has helped me in this area.

What people need to understand is that CB is not a drug in the way people think of them. It simply supplies the brain with the building blocks it needs to repair ITSELF. So, trying to come up with a definitive list of things it help would be futile.

I have no doubt that it is effective for ANY non-inborn brain issue.

Yeah it was just a general question towards everyone who has tried it.

Interesting.

I'm trying to fix post benzodiazapine withdrawal, it's really damaged by brain and I miss my emotions and memory.

I heard that russianbear guy talk about him feeling like the best moments of his childhood while on it. I want that.

Did cerebrolysin increase the power of your emotions(did you feel emotions more consistently and/or have deeper emotions) while on this?
This isn't really something I can find in a medical paper.

I'm not sure if you are replying to someone or what, but it has helped me in this area.

What people need to understand is that CB is not a drug in the way people think of them. It simply supplies the brain with the building blocks it needs to repair ITSELF. So, trying to come up with a definitive list of things it help would be futile.

I have no doubt that it is effective for ANY non-inborn brain issue.

Interesting.

I'm trying to fix post benzodiazapine withdrawal, it's really damaged by brain and I miss my emotions and memory.

I heard that russianbear guy talk about him feeling like the best moments of his childhood while on it. I want that.

You might want to look into:
demopressin
vasopressin
oxytocin

First week results based on a scale of -1 to 1, in 1/5 increments. 0 = no change.

Alcohol Sensitivity: Not tested
Alcohol Hangover Severity: Not tested
Caffeine Sensitivity: I don't drink coffee, tea or coke
Other drug Sensitivities: Not taking anything else
Anti-Anxiety: 3/5
Anti-Stress: 2/5
Anti-Depressant: 3/5
Social Ability: 4/5
Speech: 3/5
Concentration: 2/5
Motivation: 1/5
Happiness: 2/5
Clarity: 2/5
Mental Energy: 4/5
Physical Energy: Not tested
Cognitive Benefit: 2/5
Memory Benefit: 3/5

Long Term Positive Effects: N/A
Drug Potency: 3/5
Time to Effect: 3 days

Other possible effects:
Emotional Sensitivity: Not Noticed
Tolerance: Not Noticed
Vision: Not Noticed
Hearing: Not Noticed
Smell: Not Noticed
Libido: Libido is the same. Reduced masturbation due to reduced stress/anxiety.
Headaches: Not Noticed
Dexterity: Not Noticed
Sleep: Not Noticed
Flu Like Symptoms: Not Noticed
Increased Hunger: Increased hunger was noticed, probably due to the symptom below
Diarrhea: Intermittent

Personal Details:
Male
Age: Mid twenties
Weight: Mid Eighties
Job: Stressful
General Health: Very good

Mr Matsubayashi, that's incredible after only one week!

I injected myself in what I think is the Ventrogluteal muscle for the first time 30 minutes ago. I have two important questions regarding storage, given that I split the 10 ml ampule into two dosages for two separate days:

1. Do I store the syringe with the leftover cerebrolysin in the fridge or in my room?
2. Do I store the syringe with the needle (and its cap) or without it? Surely with the needle and cap sounds better for contamination, but in this thread for this as for my other question the responses seem to be a bit mixed.

Also just curious, if there is no blood flowing to the syringe when you aspirate and you are in the general area around the Ventrogluteal and the Dorsogluteal muscle is there something wrong that you can hit with a 1'' - 1.25'' needle? It didn't really hurt me (i could feel the needle going in, but it didn't really hurt) and I am going to be doing my next injections around the same spot, so I am curious if I could by mistake do it in a wrong spot?
I mean, given that CRB seems to be active subq, iv and im are there even many truly wrong spots?
Edited by FDA Approved, 22 January 2013 - 03:55 PM.

First week results based on a scale of -1 to 1, in 1/5 increments. 0 = no change.

Alcohol Sensitivity: Not tested
Alcohol Hangover Severity: Not tested
Caffeine Sensitivity: I don't drink coffee, tea or coke
Other drug Sensitivities: Not taking anything else
Anti-Anxiety: 3/5
Anti-Stress: 2/5
Anti-Depressant: 3/5
Social Ability: 4/5
Speech: 3/5
Concentration: 2/5
Motivation: 1/5
Happiness: 2/5
Clarity: 2/5
Mental Energy: 4/5
Physical Energy: Not tested
Cognitive Benefit: 2/5
Memory Benefit: 3/5

Long Term Positive Effects: N/A
Drug Potency: 3/5
Time to Effect: 3 days

Other possible effects:
Emotional Sensitivity: Not Noticed
Tolerance: Not Noticed
Vision: Not Noticed
Hearing: Not Noticed
Smell: Not Noticed
Libido: Libido is the same. Reduced masturbation due to reduced stress/anxiety.
Headaches: Not Noticed
Dexterity: Not Noticed
Sleep: Not Noticed
Flu Like Symptoms: Not Noticed
Increased Hunger: Increased hunger was noticed, probably due to the symptom below
Diarrhea: Intermittent

Personal Details:
Male
Age: Mid twenties
Weight: Mid Eighties
Job: Stressful
General Health: Very good

Can you explain memory and social ability? Also is your mental health generally in good shape?

Sweet Jesus.. Just read the entire thread only taking a break for eating lunch..

Im defintitely gonna save up some money and buy 250ml for 5ml/d 5on2off schedule..

When i was a teenager i was the smartest kid in school. Im defintely not stupid now despite having experimented, and to some degree still continuing to do so, but i would be a liar if i told you there wasnt any damage to my cognital functions of 10 years drug abuse.

I'm on Piracetam, currently at 4.8g/d, dosing down from 12g/d lately. And i like what piracetam gives me. But as soon as the effects of Pira is gone, im crashing to my former state of cognital performance.

Only thing im worried about is if it will "kill" my creativity I somehow contribute to having experimented alot, allowing me to "think outside the box". Creativity that make me prosper as an entrepreneur..

But the effects of Cerebrolysin seems mindblowing.. IM IN

Im defintitely gonna save up some money and buy 250ml for 5ml/d 5on2off schedule..

You need 100 ml for that normally.

Im defintitely gonna save up some money and buy 250ml for 5ml/d 5on2off schedule..

You need 100 ml for that normally.

That depends on how long i'm willing to run it, and if i choose to up the dose to 10ml as some people swear by as the optimum dose for noticeable effects.

The last thing i feel like is running dry as it kicks in. Better safe than sorry.

Re the safety of Cerebrolysin: Is the reason cere is considered safe because it only contains prions smaller than the known dangerous prions?

Is there any literature looking at the safety of cere in relation to spongiform brain diseases?

I remember reading about a mouse study where the mice were infected with hamster prions (generally thought that there's no cross species infection between mice and hamster i think?), and even though they didn't display any symptoms of neurodegeneration, when the mice were sacrificed and examined, their brains were riddled with hamster prions. IE carriers.

Why are these issues not of concern to cere users? Is there literature from Ewewe about this?

Not wanting to cause alarm through my half education on the matter, but want to resolve my own queries/concerns before trying it.

Thanks if anyone can provide info.

First week results based on a scale of -1 to 1, in 1/5 increments. 0 = no change.

Alcohol Sensitivity: Not tested
Alcohol Hangover Severity: Not tested
Caffeine Sensitivity: I don't drink coffee, tea or coke
Ect

Can you explain memory and social ability? Also is your mental health generally in good shape?

Just to qualify my results, +1 is an excellent improvement. Take it with a grain of salt, I imagine that the first weeks results will be more heavily influenced by placebo. My initial fear of needles made every injection feel like a triumph as well :P

Someone commented earlier that they could construct old memories more easily, I experienced the same thing. I also noticed an improvement in short term memory, I think the short term memory improvement was related to improved mood and mental clarity.

Social inhibitions were reduced and I could read people easier. Sometimes in conversation I found myself actively choosing between a number of responses which is a first for me.

My mental health isn't terrible. I'm prone to anxiety and have been a bit blue and strung out on account of relationship troubles and a new job. Nothing worth medicating.

Just to clarify, how exactly is the IV route of administering Cerebrolysin 5x stronger than IM? I understand that it would get to the bloodstream quicker (almost instaneously, compared to the 45-or-so minutes of IM'ing), but is it actually more effective/beneficial to one's own brain in the long run? sorry if this is a stupid question.

Also, if I'm IV'ing 10ml (undiluted) of CB with a needle and no saline lock, how slowly should I take to inject it in full?

Also, if I'm IV'ing 10ml (undiluted) of CB with a needle and no saline lock, how slowly should I take to inject it in full?

Is the cere for i.v. ?

.. also noticed an improvement in short term memory, I think the short term memory improvement was related to improved mood and mental clarity.

My mental health isn't terrible. I'm prone to anxiety and have been a bit blue and strung out on account of relationship troubles and a new job. Nothing worth medicating.

I agree that the better memory may be from these factors... Buy Very tuff to say.

Can you tell me if your driving abilities improve ? I found mine trippled while on cere. i can better trace my path because elements in my view, moving or static, are captured easily and monitored by a sub program. My main focus of course is what's in front of me but other details in the environement, like info further away or peripheric awareness, are being analysed in the background. Let me know if you come across such experience.

By the way, i play battlefied 3 on playstation, a first person shooter game, and my score exploses if i'm on a cycle.

Also, if I'm IV'ing 10ml (undiluted) of CB with a needle and no saline lock, how slowly should I take to inject it in full?

Is the cere for i.v. ?

Yep

Wooooohooooooo! Finally got my 100 ml Cbl. Will be going to the pharmacy later today or maybe tomorrow to acquire the injection equipment. I will be going for the 5 days on 2 days off routine, and don't know if I can last till Monday before starting. I will be doing approximately 30 minutes of dual-n-back every day, and do the cambridgesciences tests once a week or so to track my progress (if any) in various forms of intelligence. At the end of first cycle (one month), I will also take two IQ tests: http://www.iqout.com/ and http://www.mensa.no/...jemmetest.html. Some time ago I scored 105 on the first one and 113 on the latter. The first one I found incredibly hard.

I think my driving has become worse! Haha
I have certainly become more care-free on Cere. There have been a few cases where I felt confident to pull off maneuvers I wouldn't normally do, they were executed well but perhaps this is an indication of increased risk taking? Testosterone? Masturbation has reduced drastically but my overall libido is the same as far as I can tell. My mechanism for masturbation has been anxiety/stress which has since been alleviated by Cere.

It sounds like battlefield 3 is an excellent metric for you SunshineFrost, I don't have any games I could use to that end, only my performance on the job which I feel has improved noticeably.

There is nothing better than a Cere clarity rush in the morning and the mental energy to be productive to days end.
Edited by Mr Matsubayashi, 25 January 2013 - 12:23 PM.

Does anyone notice an improved ability to deconstruct and assimilate foreign concepts while on cere?

Does anyone notice an improved ability to deconstruct and assimilate foreign concepts while on cere?

slightly. I see most improvement on memory. boosting working memory could help assimilate concepts, by helping a person keep more factors floating around in there head(working memory) at once while simultaneously constructing and consolidating the concept.

Would cere left in a frdge for 24 hours loose any potency? I have 10 10ml ampules left and i want to do a 20 day cycle with 5 ml each day.
Edited by Plasticperson, 25 January 2013 - 04:44 PM.

Does anyone notice an improved ability to deconstruct and assimilate foreign concepts while on cere?

slightly. I see most improvement on memory. boosting working memory could help assimilate concepts, by helping a person keep more factors floating around in there head(working memory) at once while simultaneously constructing and consolidating the concept.

Would cere left in a frdge for 24 hours loose any potency? I have 10 10ml ampules left and i want to do a 20 day cycle with 5 ml each day.

Cerebrolysin should not be frozen, but stored at room temp:

http://www.bppharma....ert leaflet.pdf
http://contraceptin....product_id=1212
Edited by Megatrone, 25 January 2013 - 05:31 PM.

Does anyone notice an improved ability to deconstruct and assimilate foreign concepts while on cere?

slightly. I see most improvement on memory. boosting working memory could help assimilate concepts, by helping a person keep more factors floating around in there head(working memory) at once while simultaneously constructing and consolidating the concept.

Would cere left in a frdge for 24 hours loose any potency? I have 10 10ml ampules left and i want to do a 20 day cycle with 5 ml each day.

I keep mine (5ml out of the 10ml vial) in syringes in sealed bags in the fridge since this is what other people in this thread seem to be doing but nobody answered whether I should leave the syringes. If I had to guess if you are not leaving it in the open (and maybe even if you do) it probably doesn't lose its potency or at least it doesn't seem to have lost potency for the rest of the people on here who report leaving crb overnight during their cycles.

Has anyone had contact with Gerovital in the last few days? I reordered on the 20th and have yet to receive any communication with them. I sent off a email to them earlier today, but have not heard back yet.
Edited by zilla1126, 25 January 2013 - 09:13 PM.

Anyone ever bought from nootropics.eu ?

They look a bit shady. Their email adress is a @gmail.com
Kindda unproffesional somehow.
Also, they state they sell Choline, yet it cannot be found on their website!

So.. Any experience with them?

Anyone have experience taking Cere with Hydergine and/or Lion's Mane mushroom? I plan on using all 3 in my daily stack over the next several months.
Edited by Xenix, 26 January 2013 - 05:27 AM.

Anyone ever bought from nootropics.eu ?

They look a bit shady. Their email adress is a @gmail.com
Kindda unproffesional somehow.
Also, they state they sell Choline, yet it cannot be found on their website!

So.. Any experience with them?

I just placed an order about two days ago. I'll let you know how it goes.


I am reading conflicting opinion on the size gauge of needle to use. Can anyone clarify what gauge needle I should go buy? I'm hearing people say an 18 guage is good while others are saying you have to use a 23 guage needle.