"they claim that resveratrol mimics calorie restriction"Andre, it does. At least partially. One of the most significant peer-reviewed studies published in recent years was entitled, "
Resveratrol is a partial CR mimetic" at even "low" doses (equivalent of 800 mg/daily in 150 lb. human, not a dose sufficient to trigger SIRT1 activation). That study was discussed on these boards endlessly. Didn't you post in the threads?
Here's a link to study:
http://www.plosone.o...al.pone.0002264Abstract:
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg−1 day−1), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles.
We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.
Fairly prestigious list of principals for this study:
Jamie L. Barger1, Tsuyoshi Kayo1, James M. Vann2,3, Edward B. Arias4, Jelai Wang5, Timothy A. Hacker6, Ying Wang7, Daniel Raederstorff7, Jason D. Morrow8,9, Christiaan Leeuwenburgh10, David B. Allison11, Kurt W. Saupe6, Gregory D. Cartee4, Richard Weindruch12*, Tomas A. Prolla2,3*
1 LifeGen Technologies, LLC, Madison, Wisconsin, United States of America, 2 Department of Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America, 3 Department of Genetics, University of Wisconsin, Madison, Wisconsin, United States of America, 4 Division of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America, 5 Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, 6 Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 7 R&D Human Nutrition and Health, DSM Nutritional Products Ltd., Basel, Switzerland, 8 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 9 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, 10 Department of Aging and Geriatrics and College of Medicine, University of Florida, Gainesville, Florida, United States of America, 11 Section on Statistical Genetics, Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, 12 Department of Medicine and Veterans Administration Hospital, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
Edited by TianZi, 11 May 2009 - 04:00 AM.