LONGECITY

Hi,
I am HIGHLY sensitive to chemical and MSG. I have done some research and have been using magnesium glycinate to block the nmda receptor. Then after more research I found that glycine opens up that receptor. I'm confused and am reading different things on this. I am looking to find the best mag supplement to help block this receptor. I realize that nothing cures this but will aid just a little. There are so many different mag supplements out there. I was reading where someone on here stated he took mag glycinate which is magnesium and glycine to block that receptor. Now I am confused. In Dr. russell blaylock's book about neurotoxins he states glycine opens up that receptor. and to stay away from it. Anyone know about this?

Thanks,
Mamie

Glycine is needed along with glutamate to activate the NMDA receptor. Whether glycine actually increases the amount of NMDA activation is debatable, since glutamate is the main control mechanism for this receptor.

The thing about magnesium is that there's already magnesium in all your NMDA receptors when they are not firing. Magnesium sits in the ion channel of the receptor, and is pushed aside when voltage comes through the cell. This means that if you are not deficient in magnesium, the additive effect of putting more magnesium is unlikely to block that many more receptors, as the magnesium is already there, and is unlikely to have much of an NMDA antagonist effect in the traditional sense. If you are looking for NMDA antagonism, look into DXM (Robitussin), or Memantine, which is easily ordered online.

However, what is the link between your chemical sensitivities and NMDA? Why do you think an NMDA antagonist will help that? It's unlikely. If you want to deal with those sensitivities, look into a treatment called LDA (Low Dose Allergens) aka EPD (Enzyme Potentiated Desensitization). I use to be intolerant to gluten, dairy, soy, eggs, nuts and peanuts before this treatment. Now I can eat whatever I want. It's also been slowly reducing my own chemical sensitivities. Not many doctors do LDA, but if you can find one near you I can't recommend it enough.

Hope that helps.
Edited by OneScrewLoose, 23 October 2011 - 12:44 AM.

Hi One,
Just because i read that mag blocks the nmda receptor. that's why I was looking for mag. they say also co q 10 b 12.
I have no idea what caused all of this. It just happened this year. so you have done this treatment. Is this where they inject the actual allergens into you. NOw these are foods. But you say your chemical sensitivity has gone away as well? Were you sensitive to MSG as well? I'm glad I stopped the mag glycine anyway.

Thanks for the helpful info.

My point is that because of the way the receptor operates, whether or not the magnesium is in that ion channel is not a function of the amount of magnesium you have (unless you are deficient), but rather a function of whether the cell is receiving a voltage spike or not. The receptor being off is what puts the magnesium ion in there, not whether you have more magnesium.

Yes, the LDA shots put tiny amount of allergens in along with an enzyme that teaches your T-Cells not to react to the allergens. There are three different shots when you get LDA, and you don't have to get them all. One is for food, one is for chemicals, and one is for environmental sensitivities (pets, pollen, etc...). I get all three because I have sensitivities across the board and it doesn't cost me more. I was not sensitive to MSG.
Edited by OneScrewLoose, 23 October 2011 - 01:51 AM.

I'm trying to wrap the mag thing around my brain. I also read where atp helps with this too.
I'm googling away. I live in Houston. I see you are saying they have LDA for chemicals as well. I can't seem to find anything in Houston. Which is surprising. I bet it's expensive too. I have soy insensitivites as well as eggs and gluten. basically the whole works.
so If I'm not deficient in mag, then there is no use to even take it???
Miserable way to live as I'm sure you know.

Magnesium is involved in many processes in the body beyond just sitting in your NMDA receptors. I take 200mg of Magnesium Glycinate before I go to bed.

Yeah, it is a crappy way to live. And LDA is a bit expensive. It's $250 per shot (includes all three shots), for the doctor I go to, every two months to start with, for a year, and then they are spaced out more. Not everyone responds right away, and it's not even guaranteed to work, but I was lucky and all my intolerances went away after the first shot. I am now already gonna space it out to every three or four months, after three shots, because I am doing so well.

Here's some info:
http://www.dma.org/~...rgy/epd_faq.htm

And a list of physicians that do it:
http://www.drshrader..._physicians.htm

There's a bunch of them in Texas so you should be able to get a physician who does it. I was lucky in that mine is walking distance from me.

thanks for all the info. Man did you luck out. lol. But glad you r feeling better and that it worked. What do you think about mag chloride or orotate?

thanks again.

I talked with both of these places that are near me. Isn't there something about NOT eating certain foods while they do this? And the one doc in katy did not want to even touch me because I went into ana shock one day and don't even know what it was from. I know sounds weird but I did not know about any of this then. The only thing I did different that day was drink ACV with honey. AND I was food tested in Houston and they only thing that came up was limes and lemons. But they told me well these tests don't always come out right if the food is not in you. Geeze.
$650.00 down the drain.

Yes, you have a sensitive period the day before, during and after the shot in which if you eat foods not prescribed by the LDA diet for those three days, you risk actually developing new allergies. Right after the shot you have to stay in doors to not expose yourself to possible environmental allergens to prevent developing allergies to those. But if you do it right there should be no problem.

What is ACV?

If you were food tested it is likely for IgE antibodies, which mediate allergies. But intolerances in the gut are mediated by IgA. You can get that sort of thing tested at enterolab.com, which I did 4 years back.

I don't know much about magnesium orotate. I don't know if magnesium chloride is chelated, which means it wouldn't be absorbed so easily. I usually see magnesium glycinate recommended around here, though some people use other forms and you can do a search for other threads:

http://www.google.co...esium+longecity

I use this:
http://www.iherb.com...Caps/21160?at=0
Edited by OneScrewLoose, 23 October 2011 - 03:19 AM.

Hi One,
thanks for the help and the links. It really looks like each to his own on the magnesium. you know? I bought mine from purebulk.com no additives or fillers. Its a powder. All of their stuff is. I was taking mag gly. I found orotate on Beyond a Century in powder form as well. Then I called Ancient minerals and they are sending me a sample of mag chloride. transdermal. Burns but people swallow it too.

ACV is apple cider vinegar. lol. do you take any probiotics?

well this was not it but I got tested.
immunoglobin m,a and e

E was very high. The other two were normal. I don't even know what the e is. But it was 471. (H)

E was very high for what foods/substances? As for ana shock, I was told that the doses of allergens are so low that they should not induce any allergic reaction. Spend some time with that link I gave you on EPD, and consider if it's right for you.

I've taken probiotics but they don't seem to do anything for me. If you got powdered magnesium, you may want to get this:
http://www.amazon.co...19350735&sr=8-1

I've read that astaxanthin may help to protect glutamate sensitive individuals (PMID 20828541).

Hi One,
I take powered form on purpose. I always have to get veggie caps because gelatin is one of the number one listings on msg sensitivity. And it's true too if you are sensitive. Boy that thing looks nifty.
Thanks......

I've taken probiotics but they don't seem to do anything for me. If you got powdered magnesium, you may want to get this:
http://www.amazon.co...19350735&sr=8-1

So I did a search on the gelatin thing and it appears gelatin can contain 10% glutamic acid. Surprise to me. But are you so sensitive you can't take gelatin caps? Have you tried?
Edited by OneScrewLoose, 24 October 2011 - 10:12 PM.

It's Pitiful. Oh yeah. Back when I find out through symptoms and did not know what the heck they were, finally figured it out. I have to have my meds compounded.