Anti Aging Pill
Googoltarian
27 Jun 2012
http://pubmedcentral...i?artid=1552115
http://www.longecity...ed-antioxidant/
Molecule which professor drew is (click to enlarge):
SkQ.gif 7.72KB
20 downloads
http://www.longecity...ed-antioxidant/
Molecule which professor drew is (click to enlarge):
SkQ.gif 7.72KB
20 downloads
Danail Bulgaria
03 Jul 2012
The two sibling rats experiment looked very promissing. I can't wait to see experiments with volunteering people
treonsverdery
17 Jul 2012
a description online at pubmed says
One of the most striking changes during mammal aging is a progressive involution of the thymus, associated with an increase in susceptibility to infections, autoimmune diseases and cancer. In order to delay age-related processes, we have developed mitochondria-targeted antioxidant plastoquinonyl decyltriphenyl phosphonium (SkQ1). Here we report that, at low doses, SkQ1 (250 nmol/kg per day) inhibited age-dependent involution of the thymus in normal (Wistar) and senescence-prone (OXYS) rats. SkQ1 preserved total weight and volume of the organ, the volume of thymic cortex and medulla, the thymic cellularity, and the number of CD3+, CD4+, and CD8+ cells in the thymus. Moreover, SkQ1 was especially effective in senescence-prone rats. Thus SkQ1 slows down age-linked decline of the immune system, explaining prevention by this compound of infection-caused death in rodents, previously described in our group.
The progression of thymus size among people goes from obviously radiographically visible at kids to mostly resorbed at 20th century adults. I have wondered if there is a genetics of having a kid sized thymus to maturity then seeing if those people were particularly immune to diseases. If this actually increases the mass of the human adult thymus then it may reasonably improve the human immune system
I dont see why that causes the longevity thing though. similarly there is actually another drug where the fluid reverses oxidative harm to crystalline proteins n acetyl carnosine fluid also cures cataracts. http://en.wikipedia....Acetylcarnosine
I think its awesome a scientist found a highly effective antioxidant that may also increase the size of the human thymus, reducing the risk of disease. I dont have a clue why it would increase MLS though. yet if does, it does.
It has calming, lazifying effects on young mice which is concerning.
SkQ1 treatment significantly decreased locomotor activity (in 12-15 months old SHR and 129/Sv mice) and exercise tolerance in old (20 months) SHR mice. The treatment with SkQ1 (0,5-50 nmol/kg day) increased parameters of the life span in SHR mice (mean life span, mean life span of the last 10% of survival, median and maximum life span) without significant effect on the life span in 129/Sv and HER-2/neu mice. There was no reliable difference in tumor development in all SkQ1-treated mice strains as compared with the control. The drug considerably inhibited the incidence of age-associated non-tumor pathology in SHR mice. Our data suggest geroprotective activity of SkQ1, and a lack of toxic or carcinogenic activities during long term use.
so: it makes young mice less active, makes old mice avoid exercise, while making them generally weller. On one mouse kind of three it increased longevity an unstated amount.
Theres a possibility that if it shows longevity effects on SHR mouse tissue cultures, yet none at 129/sv mouse tissue cultures yet shows longevizing effects on human tissue cultures that it will make people live longer. Perhaps the people who take it for other purposes will describe its effect as a longevity drug.
Noting that is is a nice antioxidant that keeps mice from being dead perhaps it could be an effective food preservative with marvelous disease prevention side effects!
One of the most striking changes during mammal aging is a progressive involution of the thymus, associated with an increase in susceptibility to infections, autoimmune diseases and cancer. In order to delay age-related processes, we have developed mitochondria-targeted antioxidant plastoquinonyl decyltriphenyl phosphonium (SkQ1). Here we report that, at low doses, SkQ1 (250 nmol/kg per day) inhibited age-dependent involution of the thymus in normal (Wistar) and senescence-prone (OXYS) rats. SkQ1 preserved total weight and volume of the organ, the volume of thymic cortex and medulla, the thymic cellularity, and the number of CD3+, CD4+, and CD8+ cells in the thymus. Moreover, SkQ1 was especially effective in senescence-prone rats. Thus SkQ1 slows down age-linked decline of the immune system, explaining prevention by this compound of infection-caused death in rodents, previously described in our group.
The progression of thymus size among people goes from obviously radiographically visible at kids to mostly resorbed at 20th century adults. I have wondered if there is a genetics of having a kid sized thymus to maturity then seeing if those people were particularly immune to diseases. If this actually increases the mass of the human adult thymus then it may reasonably improve the human immune system
I dont see why that causes the longevity thing though. similarly there is actually another drug where the fluid reverses oxidative harm to crystalline proteins n acetyl carnosine fluid also cures cataracts. http://en.wikipedia....Acetylcarnosine
I think its awesome a scientist found a highly effective antioxidant that may also increase the size of the human thymus, reducing the risk of disease. I dont have a clue why it would increase MLS though. yet if does, it does.
It has calming, lazifying effects on young mice which is concerning.
SkQ1 treatment significantly decreased locomotor activity (in 12-15 months old SHR and 129/Sv mice) and exercise tolerance in old (20 months) SHR mice. The treatment with SkQ1 (0,5-50 nmol/kg day) increased parameters of the life span in SHR mice (mean life span, mean life span of the last 10% of survival, median and maximum life span) without significant effect on the life span in 129/Sv and HER-2/neu mice. There was no reliable difference in tumor development in all SkQ1-treated mice strains as compared with the control. The drug considerably inhibited the incidence of age-associated non-tumor pathology in SHR mice. Our data suggest geroprotective activity of SkQ1, and a lack of toxic or carcinogenic activities during long term use.
so: it makes young mice less active, makes old mice avoid exercise, while making them generally weller. On one mouse kind of three it increased longevity an unstated amount.
Theres a possibility that if it shows longevity effects on SHR mouse tissue cultures, yet none at 129/sv mouse tissue cultures yet shows longevizing effects on human tissue cultures that it will make people live longer. Perhaps the people who take it for other purposes will describe its effect as a longevity drug.
Noting that is is a nice antioxidant that keeps mice from being dead perhaps it could be an effective food preservative with marvelous disease prevention side effects!
niner
17 Jul 2012
The two sibling rats experiment looked very promissing. I can't wait to see experiments with volunteering people
I speculate that C60 reacts with olive oil to produce a compound that is similar in principle to the Skulachev ions being described here. After enzymatic hydrolysis, the product would be a long chain fatty acid with a fullerene bound to the chain. This then takes up residence in the mitochondrial membrane, where the C60 serves as a very potent means of neutralizing free radicals. This is all being discussed in the new C60health forum, under the nanotech forum. There are a couple dozen humans already using it. It was recently reported in the literature to increase the median lifespan of Wistar rats by 90% over controls.
Danail Bulgaria
19 Jul 2012
In this case I can't wait to see the results in human studies both for the Russian molecule and the C60
Turnbuckle
19 Jul 2012
The increase in longevity of his drug is much less impressive than C60. Here it is for hamsters--
Source: http://www.ncbi.nlm....56/?tool=pubmed
Edited by Turnbuckle, 19 July 2012 - 01:31 PM.
Source: http://www.ncbi.nlm....56/?tool=pubmed
Attached Files
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Edited by Turnbuckle, 19 July 2012 - 01:31 PM.
treonsverdery
19 Jul 2012
If I was with a competing pharmaceutical company I would blurt out "hey, if we give humans metformin with acetyl carnosine we could get highly similar or better results" thats because the stuff strongly longevized just one type of mouse. If you give the right tenth or twentieth of the human population metformin it will cure or avert diabetes strongly improving their longevity, it also has a general longevity effect. gradual oral acetyl carnosine may cure cataracts
I think this might be a nifty food preservative as it has similarities to TBHQ as well as BHT as well as other polyphenols.
noting that spermidine makes mice live about 90 pct to 100 pct longer at the LKM512 study they could make a version with a NH2 on the \/\/\/\/ akane as well as possibly butylating some of the phenols then putting a NH2 on those (translation put /\/\/NH2 on the farthest <=> to look like spermidine)
This also creates an opportunity to think about the benefits of the polypill or better polypills
anyway it is wonderful an actual researcher is creating an actual longevity chemical then seeing it to public availability
I think this might be a nifty food preservative as it has similarities to TBHQ as well as BHT as well as other polyphenols.
noting that spermidine makes mice live about 90 pct to 100 pct longer at the LKM512 study they could make a version with a NH2 on the \/\/\/\/ akane as well as possibly butylating some of the phenols then putting a NH2 on those (translation put /\/\/NH2 on the farthest <=> to look like spermidine)
This also creates an opportunity to think about the benefits of the polypill or better polypills
anyway it is wonderful an actual researcher is creating an actual longevity chemical then seeing it to public availability
