LONGECITY

figure we could use a thread like this, because every one wants better hearing and at some point everyone experiences damage to hearing whether it be tinnitis or from social life or work conditions.

http://en.wikipedia.org/wiki/Hair_cell
http://en.wikipedia.org/wiki/Deafness
http://www.scienceda...01124214722.htm
http://www.scienceda...80830005613.htm
http://www.longecity...m-hearing-loss/
http://www.telegraph...aring-loss.html
http://neuromuscular...lab/trophic.htm
http://www.ncbi.nlm....pubmed/15072640
http://www.jneurosci.../1/216.full.pdf
Edited by CIMN, 19 August 2012 - 08:12 PM.

Good idea for thread! I've actually recently (several episodes over last week) experienced strongly improved hearing from combining fo-ti (1g x 2 times daily) with piracetam intake (about 2.4g x 2 times daily). The effect seems delayed from the intake of the fo-ti (organic powder) with about 24 hrs or a bit more. The effect is strong enough to slightly unsettle me (I've had about 30% less hearing on one ear for more than 15 years so sudden increase in hearing is quite incredible..).

Good idea for thread! I've actually recently (several episodes over last week) experienced strongly improved hearing from combining fo-ti (1g x 2 times daily) with piracetam intake (about 2.4g x 2 times daily). The effect seems delayed from the intake of the fo-ti (organic powder) with about 24 hrs or a bit more. The effect is strong enough to slightly unsettle me (I've had about 30% less hearing on one ear for more than 15 years so sudden increase in hearing is quite incredible..).

That is very interesting. Theres a thread here on auditory sensitivity http://www.longecity...ry-sensitivity/

I was thinking whether lions mane extract may be a interesting option for haring loss, because if it can mimic NGF then perhaps applying it to the inner ear may provide some form of regeneration of the cells there.

If anyone has anything to share in this topic please share

it seems stem cells can really help regenerate the cells in hearing loss, but how can that be done in a economical and available way?
http://www.stem-cell...om/hearing-loss
http://www.hearinglo...s/drug/drug.htm

Delayed neurotrophin treatment following deafness rescues spiral ganglion cells from death and promotes regrowth of auditory nerve peripheral processes: effects of brain-derived neurotrophic factor and fibroblast growth factor.
http://www.ncbi.nlm....pubmed/17492794

p75(NTR) expression and nuclear localization of p75(NTR) intracellular domain in spiral ganglion Schwann cells following deafness correlate with cell proliferation.

http://www.ncbi.nlm....pubmed/21658451

http://www.scienceda...00630071258.htm
Edited by CIMN, 20 August 2012 - 01:28 AM.

There are lots of studies on NAC and hearing.

Some pacific islanders used fresh turmeric for some kinds of hearing loss, like in an elderly man with hardened arteries and blockages in his body. Dried turmeric would probably work well too. Don't use too much or at all if it disagrees with you. I would take it after a meal. You could put it in a gel cap. Curry powder might work too. If your hearing loss is from noise exposure, I don't know if it would work. Avoid noise.

Some pacific islanders used fresh turmeric for some kinds of hearing loss, like in an elderly man with hardened arteries and blockages in his body. Dried turmeric would probably work well too. Don't use too much or at all if it disagrees with you. I would take it after a meal. You could put it in a gel cap. Curry powder might work too. If your hearing loss is from noise exposure, I don't know if it would work. Avoid noise.

Warning!

I can't advice or say how safe it is to put things in your ear, it might actually cause damage to the inner ear cells when trying to do the opposite..

i suppose some form of liquid would be safe or a type of gel, but you'd have to look into the studies done by scientist to see what they recommend to use for administration/coating, i think they were looking into safe forms of administration, so perhaps there is a risk of causing damage with the wrong type of gel.

I think the idea was they were applying the therapy directly to the inner ear.
i think you meant to just ingest the substances.

here is an example of a hydrogel being used
http://www.biomedcen...1741-7015/8/76/
Edited by CIMN, 20 August 2012 - 04:36 AM.

I can't be sure but what I can tell is supplementation of piracetam during 1,5 week significantly decreased my tinnitus. My tinnitus was caused when I was in a meditation session and what I fool was I when I took 2g of oxiracetam right after that, I was extremely relaxed and I took a huge stimulant, result was a huge tinnitus. Unbearable the first days then subsided a bit over the weeks and stood constant.
I tried several treatments and thought I would go on piracetam due to my NMDA-related tinnitus theory.
I guess it made the trick, now I'm in piracetam shortage so I still get a very low tinnitus but what I'm sure is that it has highly decreased.
As for hearing loss, depending on the origin of your hearing loss, I know it can be cured with a strong vasodilator if the problem is peripheral vasodilation. But tinnitus and hearing loss are a bit alike, one symptom, an infinite number of causes and cures.

Good idea for thread! I've actually recently (several episodes over last week) experienced strongly improved hearing from combining fo-ti (1g x 2 times daily) with piracetam intake (about 2.4g x 2 times daily). The effect seems delayed from the intake of the fo-ti (organic powder) with about 24 hrs or a bit more. The effect is strong enough to slightly unsettle me (I've had about 30% less hearing on one ear for more than 15 years so sudden increase in hearing is quite incredible..).

That is very interesting. Theres a thread here on auditory sensitivity http://www.longecity...ry-sensitivity/

I was thinking whether lions mane extract may be a interesting option for haring loss, because if it can mimic NGF then perhaps applying it to the inner ear may provide some form of regeneration of the cells there.

Thanks for link to other thread: will read soon. Think your point about the NGF of Lion's Mane makes sense; especially because it might have more "hearing-targeted" effect when taken in conjunction with Piracetam which modulates GABA (among other things - also GABA is directly implicated in the discharge pattern of chopper neurons in the rat ventral cochlear nucleus which is very likely to be similar situation in humans, see: http://www.hubmed.or...gi?uids=8647717 ). Even though other people have reported hearing improvement on Piracetam alone (see: http://www.longecity...am-and-hearing/ ) it definitely took the combination of Piracetam and Lion's Mane for it to work for me.

Personnaly, i take 4 gr of piracetam for my unilateral tinitus triggered by Tramadol ( by the way one of the most ototoxic substance i have seen), it was first prescribed by my doctor (800 mg 3 times/day) but did nothing at this dosage so i upped the dose to 4 gr and it has drastically decreased my tinnitus
Edited by hadora, 22 August 2012 - 01:45 PM.

I MEANT TO TAKE THE TURMERIC ORALLY. Most herbs are.

I MEANT TO TAKE THE TURMERIC ORALLY. Most herbs are.

LOL, too late I already stuffed my ears with turmeric, so hard but eventually I managed to get several grams in there..

About 15 years ago I went to a ear doctor because I had club-noise-induced tinnitus and he prescribed Piracetam. (nootropil brand)

I didn't really comply, so whether it worked or not is irrelevant.

Brainjuice - you say that you didn't really comply. That seems to be a qualified answer. Did you comply at all? And if you didn't comply, is it because the tinnitus wasn't bad enough? I too have club noise induced tinnitus starting about 15 years ago, and while it has decreased over time since then, it occasionally bothers me enough that I would like to find an answer and eliminate it. So, did you try piracetam at all?

Thanks.

For those of you suggesting Piracetam, can this be substituted by Noopept to get the same GABA modulation?

 

I find it odd that oxiracetam caused tinnitus for Renfr, but yet piracetam can improve it. It is interesting how this happened though, it seems that we should think of stimulants like voltage in an electrical circuit. We need to expend all the "energy" on activities or else the energy can cause short circuits.    

 

Fo-Ti powder is traditionally used for treating grey hair, but I've never heard of a hearing application, no pun intended.