LONGECITY

The short story is this: you can place two species of hydra animals in the same environment at a temperature of 10 degrees Celsius. One will age (Hydra oligactis) and the other one won’t (Hydra vulgaris).

Now here are the details.

http://longevitylett...-hydra-animals/

The short story is this: you can place two species of hydra animals in the same environment at a temperature of 10 degrees Celsius. One will age (Hydra oligactis) and the other one won’t (Hydra vulgaris).

Now here are the details.

http://longevitylett...-hydra-animals/

 

Are hyrda immune from ROS being generated in their mitochondria, do they develop AGE's or lipofuscin with time?
 

The non-aging hydra species adequately replenishes its stem cells so it doesn't build up long-lived postmitotic cells. While the one that does age displays senescence and a couple of cellular modifications as mentioned in this paper:

 

http://www.tandfonli...needAccess=true

 

There is no specific mention of lipofuscin or AGEs, but presumably there is protein disorganization (myofibers) in the aging hydra.

There is no reason to collect such buildup in species that adequately replenish their cells, like the non-aging hydra.

 

 

 

The short story is this: you can place two species of hydra animals in the same environment at a temperature of 10 degrees Celsius. One will age (Hydra oligactis) and the other one won’t (Hydra vulgaris).

Now here are the details.

http://longevitylett...-hydra-animals/

 

 

Are hyrda immune from ROS being generated in their mitochondria, do they develop AGE's or lipofuscin with time?
 

 

 

Edited by erzebet, 13 September 2016 - 12:13 PM.

Humans don't replenish all of our cells. That's why we have memories stored in our brains. The proteins in our eyes doesn't replenish which is our eyes go bad with age.... And on and on.

I don't know what there is about the hydra that applies to humans. An interesting animal, but ultimately too alien to what humans are. If biological immortality rests on replacing every cell with age, then what is life and consciousness? Since everything in the body is ultimately recycled then are we not already immortal?
Edited by Rocket, 14 September 2016 - 01:49 AM.

Humans don't replenish all of our cells. That's why we have memories stored in our brains. The proteins in our eyes doesn't replenish which is our eyes go bad with age.... And on and on.

I don't know what there is about the hydra that applies to humans. An interesting animal, but ultimately too alien to what humans are. If biological immortality rests on replacing every cell with age, then what is life and consciousness? Since everything in the body is ultimately recycled then are we not already immortal?

 

Neurons have lasted over 50% longer than the average lifespan of humans, in other animals upon transplant they've lasted twice as long as the original host.  Some have suspected, and suggested, they exhibit negligible senescence and it is the aging of support cells that causes their degeneration

 

In some organisms, physiological reversal of things like lipofuscin accumulation has occurred, iirc.

 

6.5.8 Reversal of Lipofuscin Accumulation Lipofuscin accumulation
-The Future of Aging: Pathways to Human Life Extension

 

Again decades of additional lifespan(over average) proven in human without genetic modification, double lifespan of host proven in other species.

 

The brain depends on the molecular garbage export system known as the glymphatic system to function, without it it is like a city without the garbage trucks.

 

Here's an article showing that loss of brain performance, function and structure is significantly slowed in a fraction of the population

http://www.nextbigfu...g-minds-as.html

Edited by Castiel, 20 September 2016 - 08:10 PM.

just an  idea,

Are there any  parasites or symbiotic organisms known to extend lifespan of their host, particularly in mammals? My guess is that it might be possible, as it can be evolutionary advantage of some parasitic organisms to keep their host alive for longer.

just an  idea,

Are there any  parasites or symbiotic organisms known to extend lifespan of their host, particularly in mammals? My guess is that it might be possible, as it can be evolutionary advantage of some parasitic organisms to keep their host alive for longer.

 

This is exactly the topic of my next book over which I've been very quiet because I have no idea in what direction it will go

And it all started with wondering whether microbiota could be edited with CRISPR or other techniques to change metabolic pathways.

 

Depending on their life cycle, it can sometimes be in the parasite's interest to kill the host as fast as possible and other times to keep it alive. But first an example from a symbiotic organism. You know how metformin mimcs CRON and extends lifespan in a couple of species? I found this paper where metformin extended the lifespan of C. elegans by interfering with the folate and methionine metabolism in their microbiota:

https://www.ncbi.nlm...les/PMC3898468/

great! this can be very interesting direction of longevity research