LONGECITY

Out of your experience and research, what do you consider to be the best elastase and collagenase inbhibitors?

From what I understand, Elastace and collaganese break down the key components that keep skin firm.. so yeah any help would be appreciated.

Thanks! (:

To my knowledge, the only FDA approved MMP inhibitor is the antibiotic doxycycline, approved under the name Periostat for severe periodontitis. It works on MMP-2, not the MMP-1,3, and 9 active in skin photoaging.

All the major pharmaceutical companies had active MMP inhibitor prospects targetted towards arthritis, osteoporosis, cancer, atherosclerosis, heart failure around the turn of the millenium, but dismal trial results ended that era. Most of the literature seems to date from 1996-2002.

For the most part, practical systemic reductions in MMP activity will come largely through anti-inflammatory measures, in particular inhibiting the signalling chain involving NF-kB and  NADPH oxidase upstream of AP-1 and MMP expression.

Cox inhibitors (like aspirin and other NSAIDs), long-chain omega-6 fatty acids (EPA, fish oil), and food polyphenols all have a place here. Eg, the common berry/wine anthocyanidin delphidin inhibits MMP expression in vitro.

Topical Antioxidants should inhibit MMP induced by sun exposure, as well as sunscreen. http://www.nature.co...ymp200914a.html

Hold on........... I thought that Retinoids inhibit those? Anyone?

Hold on........... I thought that Retinoids inhibit those? Anyone?

http://www.futureder...t-on-tretinoin/

So Retin-A it is?

Yup retina-A/tretinoin it is

Guys let me add that White Tea is one of the best collagen and elastic booster.

Blackberry tea I have found is a good MMP enzyme inhibitor, look it up.

Make a tea mixture by putting white tea- and blackberry tea bags inside a pot of boiling water. 

Guys let me add that White Tea is one of the best collagen and elastic booster.

Blackberry tea I have found is a good MMP enzyme inhibitor, look it up.

Make a tea mixture by putting white tea- and blackberry tea bags inside a pot of boiling water. 

Well I drink store bought white tea the Twinings brand. .  . is that good for these properties or do I need to buy organic white tea or something or other?

Guys let me add that White Tea is one of the best collagen and elastic booster.

Blackberry tea I have found is a good MMP enzyme inhibitor, look it up.

Make a tea mixture by putting white tea- and blackberry tea bags inside a pot of boiling water. 

Do you mean black tea (flavored with blackberry) or tea made out of the berries? Think I've ran into the former. 

Hi.

I think this topic has been discussed before; however, I cannot seem to find the topic.

But look at this study.

http://www.ncbi.nlm....pubmed/19653897

Hi.

I think this topic has been discussed before; however, I cannot seem to find the topic.

But look at this study.

http://www.ncbi.nlm....pubmed/19653897

This is very interesting, but I would be curious how one could get the effects in vivo... Many compounds somehow work but the question is how to get it into the skin and to the places where it counts? E.g. L ascorbic acid can get absorbed by the skin under the right circumstances but many actives can't. Taking it orally does not mean that meaningful amounts will ever reach the skin...

Hi.

I think this topic has been discussed before; however, I cannot seem to find the topic.

But look at this study.

http://www.ncbi.nlm....pubmed/19653897

They studied these extracts at insanely high concentration in vitro, which makes it rather hard to say what would happen if you tried to use any of these things in a human.  They did however find that white tea was the best substance in their assay, and both white and green tea extracts have been used as both oral and topical skin treatments.

White tea shows most benefits for collagen boosting properties like that ncbi article showed,

and- blackberry tea inhibits lots of the MMP enzymes which is good for preventative measures.