LONGECITY

We all start our life in biological terms with the zygote, right? Once formed, the zygote multiplies many times to make you as a baby, ready to be born. Then, after you are born, you grow up, etc.

My question is, if there are some small chnages of the DNA, that happen after the hudge number of the cellular divisions, then does our genome change with the time? Moreover DNA damage accumulates with time, as an aging change. Can then happen so, that different cells in our body to have a slightly different genotype? For example the genotype of a random skin cell to differe in 0,000001% with the skin cell standing just next to it?

Do the cells, that we have today, have a different genotype from the zygote, that they originated? Because of the DNA damage accumulation, or the small mistakes during the DNA replication, during the cellular division? If so, can we know what was the genotype of the zygote, that staerted us? Is there a cell, that stayed completely unchanged, or can we "reverse changes" and make the zygote genotype again?

What do you think?

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There are (self proclamated at least) genetics experts here. Why not they give their opinion?

I found this paper.

Thanks! It gives an interesting information about the mutation rates, but can (at least some of them) to be reversed?

What do you mean? Mutant cells clearance?

I mean can the changes of the DNA be reversed - naturally or in a lab.

Well, a single human cell experiments around one million mutations everyday. Most of then are corrected by the cell's repair mechanisms. Mutations that aren't repaired are what is counted in that paper.

Wooow one million mutations per cell per day. Mind-blowing.

And there are mutations, that aren't repaired. This gives an explanation of the DNA damage accumulation theory. Interesting, can these mutations, (that can't be repaired by the natural repair mechanisms), be repaired in a lab, or the DNA is damaged forever?

Plus if they can be reversed, this maybe would be extremely expensive.

Yeah, amazing A sufficiently advanced biotechnology and some cryopreserved cells (or a DNA sequence stored in a computer) could do the job, but we still are far away from that.

This sketches the needed technology: https://www.fightagi...ert-freitas.php

Nanobots. Interesting concept. Unfortunately we will be long time death before the nanobots be able to recover at 100% our DNA.