Would D-serine affect cortisol levels the...
Guest_Funiture2_* 23 Jun 2015
Are the cortisol-lowering effects from phosphatidylserine due to its eventual breakdown into D-serine from L-serine or is the phosphatidylserine molecule responsible on its own? I can't seem to find info on this. Or another way to put this question is, would agonizing the NMDA receptor at the glycine site lower cortisol? Any help is appreciated.
Guest_Funiture2_* 23 Jun 2015
I did find this:
http://www.ncbi.nlm....pubmed/11282259
"As prolactin and cortisol liberation is in part influenced through NMDA-receptors we investigated whether the elevation of prolactin or cortisol plasma levels is a class effect of NMDA-antagonists and might be an appropriate marker for studying NMDA-antagonistic potency."
"Ketamine increased serum prolactin and cortisol levels (p < 0.001), whereas memantine and placebo did not affect hormone levels."
If Ketamine, an NMDA antagonist can increase cortisol, then D-serine, an agonist of NMDA, should decrease it? Tell me if my thoughts on this are wrong.
