LONGECITY

Still looks to be something going on there......

Molecules. 2016 May 18;21(5). pii: E661. doi: 10.3390/molecules21050661.

so is resveratrol good or bad with exercise? im still confused as i read quite the opposite few times now. HELP! someone please check the sponsor of this study!!!

Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice.

with such names as chang cheng ping pong etc. it was hard for me to google and find what each one of those people gets out of this study, so ill say i guess they dont work for any resveratrol producing company? we shall see in later studies.

so is resveratrol good or bad with exercise? im still confused as i read quite the opposite few times now. HELP! someone please check the sponsor of this study!!!

From what I understand, Resveratrol combined with exercise increased the muscle endurance and strength of the mice. This increased endurance and strength seems to lessen the "side-effects" of aging. 

OP: The links are broken.

I somewhat cannot agree with this (as much as I want to), because exercise in general will increase performance and endurance of muscles, so reservatrol might only increase help this further.

what about resveratrol and fasting?

with such names as chang cheng ping pong etc. it was hard for me to google and find what each one of those people gets out of this study, so ill say i guess they dont work for any resveratrol producing company? we shall see in later studies.

That's a shame because you seem really intelligent

what about resveratrol and fasting?

Yeah I am interested on this, I usually fast following a 20/4 protocol and I lift weights and a bit of cardio on the latest hours of my fasting.

This is an animal study.  PMID 23878368 finds that resveratrol blocks many of the beneficial adaptive responses to exercise in humans.

 This certainly sounds positive and its in vivo, at a reasonable dose, and in humans for once:

J Gerontol A Biol Sci Med Sci. 2017 May 13. doi: 10.1093/gerona/glx089. [Epub ahead of print]

I am suspicious of the exercise regimen in PMID 23878368

All subjects performed 8 weeks of supervised high-intensity interval training (cycle ergometer) twice a week and full body circuit training (Crossfit) once a week. Intensity of the training sessions was controlled with TEAM2 WearLink+ (Polar, Kempele, Finland) heart rate monitors. In addition subjects conducted a timed 5 km walk once a week.

The subjects were "exercise naive", and the exercise routine is one that most actual athletes would consider barely a warmup.

An unpublished study by a USCF cycling coach on himself and two of his cyclists found a slight improvement in the fourth block (1 month period) of structured training.  the dose was 400 mg vs the 250 mg in PMID 23878368.  The improvement noted was that normally after 3 training blocks, performance would plateau and diminish, as it had many times with the same and many other subjects.  With resveratrol, training continued to improve as measured by power output and oxygen consumption, as if the subjects had had a two week rest period.

I know an unpublished study doesn't prove much, but the difference in dose is significant, as is the fact of starting with trained, conditioned athletes. 

For most of us this is irrelevant and not a reason to take resveratrol, but I am curious at the different findings.

The paper malbecman posted above (I merged into this topic) shows an improvement in aged subjects.  I note the dose in that study was 500 mg. 

More studies?

An unpublished study by a USCF cycling coach on himself and two of his cyclists found a slight improvement in the fourth block (1 month period) of structured training.  the dose was 400 mg vs the 250 mg in PMID 23878368.  The improvement noted was that normally after 3 training blocks, performance would plateau and diminish, as it had many times with the same and many other subjects.  With resveratrol, training continued to improve as measured by power output and oxygen consumption, as if the subjects had had a two week rest period. 

Three subjects ... unblinded ... no control ...

[To the tune of "Tequila"}: Namma-namma-na-na-na ... Placebo!
 

In this case I don't think so.  As their coach, he was monitoring the athletes' training, and measured performance improvement beyond what the athletes should have been capable of at that point in their training.  So(they being cyclists and all) he grilled them: What are you guys on?  The answer was resveratrol, it was legal,  so he tried it on himself , not expecting much, and continued monitoring his clients.  There are other studies with better controls that have been mentioned here in this subforum, by malbecman for one.  He periodically  posts resveratrol studies..  In my admitedly less than rigorous reading, what seems to be critical is the dose.  Less than 400 mg there is no, or negative, effect.  More than 400 mg, improvement.  This does call for some kind of meta-analysis beyond my off-key rendition of Tequila.   It may have to do with PPAR activation,  someone may eventually look into it.

Telmisartan activates PPAR-delta, acting as an exercise mimetic and has been banned from sport for that reason.

Here's a possible clue https://www.hindawi..../2010/129173/  http://dx.doi.org/10.1155/2010/129173

"Under hypoxia, Resveratrol induced SIRT1, RXR-α, PPAR-α mRNA, and PPAR-γ and UCP-2 protein. "

I believe resveratrol is not what it was cracked up to be, but it is not inert.  Though the relevance to life-extension is problematical.

I tried various forms of RES, in different dosages. Except at the smallest dosages, I had bowel problems (despite having tried micronized form, etc.).

My conclusion was that RES is basically toxic. Remember that SRIT1 is a stress-response gene. It would make sense that the RES would cause SIRT1 to be activated simply because it has hypoxic effect on cells.

One more issue I had with RES was that I had no idea how much SIRT1 activation I was getting. Based many studies on stress, we know that chronic stress is a bad thing. This also would imply that SIRT1 should NOT be activated all the time. If one were to take a reasonable dose of RES, perhaps one can achieve an optimal activation of SRIT1 (without overdoing it). As one poster noted above, this would explain the positive effect of RES in some studies.

Any activation of SIRT1 by the use of chemical compounds (such as RES) can also be achieved through exercise and/or fasting. I don't see any reason to take RES.