LONGECITY

Does anyone think it is useful to combine supplementation of NR with adenosine, adenosine monophosphate or another type of nucleoside triphosphate? Or are there so many biosynthetic paths to ATP that it is unnecessary? I have read references that ATP declines with age in some tissues.

 

There was this posting some time ago: http://www.longecity...osteoarthritis/

 

Would love to hear folks thoughts!

(realize this is a reply to a yr old post)

 

I've just got some PeakATP to try, as it was available as a BOGO, so I have a 2 month supply @ 400mg/day.  Seems this molecule has been sold for some years, but with minimal attention paid to it. It's also available in a few pre-exercise powders. Perhaps there is synergy to be found with NR and NMN combined with exercise? That's what I will do.

 

Does anyone have experience with it alone or in combo with other molecules?

 

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Missoula, MT - A newly published study in the Journal of the American College of Nutrition has shown that oral ATP administration prevents exercise-induced declines in ATP while enhancing peak power and muscular excitability (the ratio of power output to muscle activation). 

In the double-blind, placebo-controlled, randomized study conducted by the University of Tampa, forty-two healthy male individuals were given either 400mg of ATP (patented PEAK ATP® provided by TSI USA Inc., Missoula Mont.) or a placebo for two weeks prior to repeated high-intensity sprinting bouts. Key findings show that oral PEAK ATP® supplementation prevented a drop in ATP, adenosine-5-diphosphate (ADP) and adenosine-5-monophosphate (AMP) levels post-exercise as well as prevented the decline of ATP in later exercise bouts. The study also showed that ATP significantly increased Wingate peak power in later exercise bouts. 

http://www.tsiinc.co...e-of-nutrition/

Key Findings

Participants taking PEAK ATP® experienced incredible benefits including:

Increased strength (147% increase over placebo)
• PEAK ATP®: 55.3 kg versus placebo: 22.4 kg
Increased power (30% increase over placebo)
• PEAK ATP®: 796 watts versus placebo: 614 watts
Increased lean body mass (100% increase over placebo)
• PEAK ATP®: 4.0 kg versus placebo: 2.1 kg
Increased muscle thickness (96% increase over placebo)
• PEAK ATP®: 4.9 mm versus placebo: 2.5 mm

http://www.peakatp.c...pa-2013-wilson/

That study seems too good to be true.

That study seems too good to be true.

 

At 1st look, I would agree. However, it was a 3-phase randomized, double-blind, and placebo- and diet-controlled intervention, registered at ClinicalTrials.gov NCT01508338. So it seems legit, in any case, I'll report back what I find.

 

And actually, ATP is the power supply of the body, and what NR and NMN, etc., are working at making more of as an end result of their actions.

I would suggest that high levels of n+r actually impair atp production when adenosine runs out which causes mitochondrial fission. Adding exogenous atp would probably induce fusion if that is correct t.

I would suggest that high levels of n+r actually impair atp production when adenosine runs out which causes mitochondrial fission. Adding exogenous atp would probably induce fusion if that is correct t.

 

Sorry, but I don't follow what you are getting at and why this would happen. Can you illustrate with some references. Thanks.

At 1st look, I would agree. However, it was a 3-phase randomized, double-blind, and placebo- and diet-controlled intervention, registered at ClinicalTrials.gov NCT01508338. So it seems legit, in any case, I'll report back what I find.

And actually, ATP is the power supply of the body, and what NR and NMN, etc., are working at making more of as an end result of their actions.

Well,let us know your experience. I'm eager to hear it.

Sorry, but I don't follow what you are getting at and why this would happen. Can you illustrate with some references. Thanks.

Fission follows from lots of exercise deleting atp. Followed by fusion and biogenesis in recovery
https://www.ncbi.nlm...ubmed/20921196/
I'm proposing that enhancing fission with n+r is caused by a adenine+ribose->adenosine until the adenine is used up. Nicotinamide keeps driving the cycle (maintain membrane polarization
https://www.ncbi.nlm...les/PMC3529804/ )
but with eventual, faster adenine depletion. Normally you would have to do work to cause this depletion, but you can speed it up with n+r which may enable a greater rebound effect from maximal training or an equivalent one from reduced loading)

Oakman:

I'd be very interested to hear an update about your ATP supplementation. What has been your experience with it?

I've actually considered it for a long time, but the cost holds me back.

Oakman:

I'd be very interested to hear an update about your ATP supplementation. What has been your experience with it?

I've actually considered it for a long time, but the cost holds me back.

 

Well, I didn't find much effect initially, but did buy again and try last summer. I used it before and/or after aerobic exercise. Maybe it did something, but I couldn't tell. Perhaps it would be better to test in isolation, with no other supplements, something I din't do. Anyway, I'm not using it presently, and no intention to try again at this point. 

I see. Thanks for your feedback.