treatment of mice w/ NMN increased precanc...
Phoebus
11 Jul 2020
Nacarelli et al. took advantage of a mouse model in which expression of oncogenic KRasG12D is restricted to the pancreas. These mice develop PanINs, which progress into PDAC under stress. Remarkably, the authors demonstrated that interventions that altered the NAD+/NADH ratio affected the SASP and disease progression: treatment of mice with NMN increased precancerous and cancerous lesions, and upregulated immune-cell infiltration as well as the expression of pro-inflammatory cytokines3 . In contrast, pharmacological NAMPT inhibition with FK866 suppressed the induction of pro-inflammatory cytokines and senescence markers in the pancreas without decreasing immune infiltration or the acinar area. These findings confirm that the pro-inflammatory SASP contributes to the progression of pancreatic cancer, and this effect is aggravated by increasing NAD+ levels with NMN treatment (Fig. 1).
The blame this on NAD+ levels, but in reality the only thing they can say is the NMN did this. We don't know if NMN raising NAD had anything to do with this or not. We can only say NMN itself raised inflammation levels and increased precancerous and cancerous lesions in mice.
Edited by Michael, 11 July 2020 - 05:42 PM.
Michael
11 Jul 2020
Phoebus, others: again, please do not post links to sites providing back doors through paywalls: you're putting Longecity at risk of paratrooping lawyers and takedown bombardment.
MikeDC
11 Jul 2020
Phoebus
11 Jul 2020
This study used model mice that develop senescent cells by design. It is garbage.
and yet FK866 suppressed the induction of pro-inflammatory cytokines and senescence markers
why didn't NMN do that? There has been claims NMN is anti inflammatory, at least in this situation it certainly was not
Edited by Phoebus, 11 July 2020 - 07:59 PM.
able
11 Jul 2020
Looks like this was published Feb 2019. Interesting, but nothing definitive. Doesn't seem like it scared researchers or investors away when it came out last year.
MikeDC
12 Jul 2020
Because the mice was generally modified. NR was shown to decrease IL-6 significantly in a human study. Two papers have shown increasing NAD+ reduces cancer growth. Similar in effectiveness as FDA approved drugs. It also increases drugs effectiveness by a few fold.and yet FK866 suppressed the induction of pro-inflammatory cytokines and senescence markers
why didn't NMN do that? There has been claims NMN is anti inflammatory, at least in this situation it certainly was not
Phoebus
12 Jul 2020
Because the mice was generally modified. NR was shown to decrease IL-6 significantly in a human study. Two papers have shown increasing NAD+ reduces cancer growth. Similar in effectiveness as FDA approved drugs. It also increases drugs effectiveness by a few fold.
which two papers show increasing nad reduces cancer growth?
MikeDC
12 Jul 2020
https://www.fiercebi...ht-glioblastomawhich two papers show increasing nad reduces cancer growth?
https://www.biorxiv.....03.21.001123v1
Edited by MikeDC, 12 July 2020 - 04:24 PM.
