LONGECITY

There are no marketed products for telomerase activation at this time. I'm am keeping a close eye on this area of research. If this becomes available it could mean a huge leap foward in Anti-aging. Geron Corporation states that they are moving forward with it via the joint venture company, TA Therapeutics, Ltd. If anyone else has any updates please post.

I searched the forum and I am shocked that in all this time nobody on this forum has mentioned the chemical epitalon (aka epithalon) which is a synthetic pineal gland hormone, that IS a telomerase activator. It increases mice's lifespan ~30% on average if I'm not mistaken, and cancer free. Treated mice had lower incidences of cancers actually. It's a 4 amino acid peptide... so small that it can be made with a basic peptide synthesizer for very cheap, if of course, you could get one of the countless owners of these machines to manufacture it for you. I came across it about a year ago when trying to find treatments for retinitis pigmentosa, a progressive degenerative condition which ultimately leads to blindness (which a family member and a friend of the family has). There is no treatment for retinitis pigmentosa and this stuff seems to have a good effect on humans (90% reported improvement). It's a Russian guy, Khavinson, who came up with it.. I e-mailed his company for info and he directed me to an Australian firm who is conducting clinical trials.. but the Australian firm didn't get back to me...

The funny thing is, I read a few articles, that all the employees of his lab, were taking these supplements voluntarily, and having great benefits from it. So I thought the guy would be forthcoming, but not really. If you want this chemical, it would probably have to be underground or for 'research purposes'. The dosing is given on several of the papers regarding this chemical, it's in the micrograms per day.... I'm sure the panacea of health problems that this chemical cures is just going to be swept under the rug, unless you guys raise some cane. :-P

BTW, the thing about the hormone, that probably makes it not give you cancer, is that it is not an unlimited supply of telomerase, as cancer would create as needed. Each dose, lengthens telomeres a bit, and you just take a daily injection or nasal inhaler.

Polypeptides can be custom manufactured by a number of companies. This is a short one with sequence: {d-ALA}{d-GLN}{d-ASP}{d-GLY}

I have an account at Genscript and got these quotes from their system:

Peptide: 4 amino acids, 1000 mg, purity >75% $407.04
Peptide: 4 amino acids, d-forms, 1000 mg, purity >75% $967.04
Peptide: 4 amino acids, d-forms 1000 mg, purity >98% $1445.76

Since it is apparently 16,000 times more powerful than melatonin, perhaps only a small amount would be needed to increase telomere length. Also, since it is so small, it should be able to be easily ingested and absorbed through the digestive tract.

Anyone have some insight? This one might be very worth trying, if we could figure out the correct dosage.

Astragalus Extracts, astragaloside IV, cycloastragenol, astragenol, and several other compounds described at http://greenwdks.tri...gevity.html#(7) and
http://greenwdks.tri...html#ASTRAGALUS
are probably the easiest and safest way to arrange telomerase activation for yourself at this time. In particular, I would suggest GAIA Extra Strength Astragalus Extract, which contains 5 mg of astragalosides per 77 drops, or some other astragaloside-specific astragalus extract. These compounds not only activate telomerase, but they are actually anti-cancer, promote wound healing, safe with good margins, extensively used in history to boost the immune system, and so forth.
Edited by jamesagreen, 11 August 2007 - 08:51 PM.

I was also curious about the current state of telomerase activation. I know the theory been kicked around and garnered significant media attention at times. What is the latest with Geron and/or research into this area of anti-aging theory?

Yeah, what the hell is going with this? I also remember and article stating that even if we go over cell division it won't give people to live forever, why?
I mean, ignoring trauma and disease..

http://www.cnn.com/H...life.extention/

Astragalus Extracts, astragaloside IV, cycloastragenol, astragenol, and several other compounds described at http://greenwdks.tri...gevity.html#(7)  and
http://greenwdks.tri...html#ASTRAGALUS
are probably the easiest and safest way to arrange telomerase activation for yourself at this time. In particular, I would suggest GAIA Extra Strength Astragalus Extract, which contains 5 mg of astragalosides per 77 drops, or some other astragaloside-specific astragalus extract. These compounds not only activate telomerase, but they are actually anti-cancer, promote wound healing, safe with good margins, extensively used in history to boost the immune system, and so forth.

Thanks for the tip! I actually am already taking a product where each 2.5ml contains:

Astragalus membranaceus root 1000mg
Ganoderma lucidum (Reishi mushroom) fruiting body 500mg
Ligustrum lucidum (Privet) fruit 500mg

I was taking it purely to boost my immune system but did not know it was a telomerase activator!

More discourse here http://www.disease-t...ad.php?p=626478 and of course here! http://www.imminst.o...6&t=15434&st=20
Edited by caston, 12 August 2007 - 05:20 PM.

I also remember and article stating that even if we go over cell division it won't give people to live forever, why? I mean, ignoring trauma and disease..

Because of this.

Because of this.

Yeah, I was thinking about making a crack about how we don't have any immortal Chinese or TCM users

I bet even with good telomere length mitos will still trigger apoptosis and the cells that do go on won't be completely free of defects even if they really are more cancer resistant.

I would say you don't see any "immortal" Chinese because for Astragalus extracts to work via telomerase promotion one would have to systematically take a concentrated extract for many decades of adult life right up to the Big Day. That works for me but nobody else would have done it without knowing beforehand that it would pay off after many years of use.

Then again... you have the strange case of Li Ching-Yuen... He was an herbalist

http://en.wikipedia....i/Li_Ching-Yuen

Hmmm... http://en.wikipedia....#Medicinal_Uses

"Gotu Kola is a minor feature in the longevity myth of the Tai Chi Chuan master Li Ching-Yun. He purportedly lived to be 256, due in part to his usage of traditional Chinese herbs including Gotu Kola.

A popular folklore tale from Sri Lanka speaks of a prominent king from the 10th century AD named Aruna who claimed that Gotu Kola provided him with energy and stamina to satisfy his 50 woman harem."


-- I want some!!

Polypeptides can be custom manufactured by a number of companies. This is a short one with sequence: {d-ALA}{d-GLN}{d-ASP}{d-GLY}

I have an account at Genscript and got these quotes from their system:

Peptide: 4 amino acids, 1000 mg, purity >75% $407.04
Peptide: 4 amino acids, d-forms, 1000 mg, purity >75% $967.04
Peptide: 4 amino acids, d-forms 1000 mg, purity >98% $1445.76

The price they have offered you is too high in my opinion, especially when you consider that it is just a tetrapeptide, not so difficult to manufacture.
Even longer peptides can be purchased for a better price.
I have the possibility to get this one in 98% purity and for a much more better price. The only problem is, that I would have to buy a little bit more than 1 gramm (at least 10 or 50), so if somebody else is interested...

Epithalon seems to be pretty interesting, the only thing which is of light concern, is that the most of the date was published by the same research group.
But if it works like it was described in some abstracts, it would be worth every cent.

See Jim Green's file on Telomerase Inhibitors and Telomerase Activators at http://greenwood.s5....notes3.html#81s . I propose to use telomerase activators while not using telomerase inhibitors for 2 weeks each month, then to use certain telomerase inhibitors without using telomerase activators for the last two weeks of each month. Also, see my notes on Telomere Remodeling with Cyclic Telomerase Activation at http://greenwood.s5....ERASEACTIVATION and my new web page address on Longevity & Life Extension problems at
http://greenwood.s5.com/longevity.html. I note that telomerase activation has been observed to commence within 24 hours of application of telomerase activators, and to disappear within 75 hours of discontinuance of telomerase activators causing hTERT to express telomerase. Of course, there are other factors to consider in minimizing cellular senescence, such as lipofuscin accumulation, which you should be fighting with ubiquinol CoQ10 or the old ubiquinone, piracetam, DMAE, or other lipofuscin removers. Mitochondrial DNA damage can be alleviated by application of alpha lipoic acid and acetyl L-carnitine. However, minimizing cellular senescence due to telomere shortening is clearly imperative, based
on many clinical studies. About all I can find locally to lengthen telomeres is astragalus extracts. Geron Patent papers seem to indicate that TA-65, marketed by TA Sciences, is cycloastragenol obtained from astragaloside iv, often regarded as the primary active ingredient in astragalus extract. See http://v3.espacenet....530ecb46d14e48b . Cycloastragenol, the smallest molecule of the astragaloside pack, is often referred to in the literature as the common alglycone of the astragalosides. Its smallest-molecule property may be why Geron recommends it at 5 mg/day rather than astragaloside iv, which they say works fine at 50 to 100 mg/day. I also note that chitosan increases the bioavailability of astragaloside iv in standard ethanolic astragalus extracts or in astragalus extracts in glycerin prepared from these.
Edited by jamesagreen, 05 January 2008 - 10:04 PM.

File length was too restricted at greenwood.s5.com to allow expansion of all my longevity files, so that the most complete updates are now kept at http://greenwoodstor.../longevity.html .

See Jim Green's file on Telomerase Inhibitors and Telomerase Activators at http://greenwoodstor...notes3.html#81s . I propose to use telomerase activators while not using telomerase inhibitors for 2 weeks each month, then to use certain telomerase inhibitors without using telomerase activators for the last two weeks of each month. Also, see my notes on Telomere Remodeling with Cyclic Telomerase Activation at http://greenwoodstor...ERASEACTIVATION and my new web page address on Longevity & Life Extension problems at
http://greenwoodstor.../longevity.html. I note that telomerase activation has been observed to commence within 24 hours of application of telomerase activators, and to disappear within 75 hours of discontinuance of telomerase activators causing hTERT to express telomerase. Of course, there are other factors to consider in minimizing cellular senescence, such as lipofuscin accumulation, which you should be fighting with ubiquinol CoQ10 or the old ubiquinone, piracetam, DMAE, or other lipofuscin removers. Mitochondrial DNA damage can be alleviated by application of alpha lipoic acid and acetyl L-carnitine. However, minimizing cellular senescence due to telomere shortening is clearly imperative, based
on many clinical studies. About all I can find locally to lengthen telomeres is astragalus extracts. Geron Patent papers seem to indicate that TA-65, marketed by TA Sciences, is cycloastragenol obtained from astragaloside iv, often regarded as the primary active ingredient in astragalus extract. See http://v3.espacenet....530ecb46d14e48b . Cycloastragenol, the smallest molecule of the astragaloside pack, is often referred to in the literature as the common alglycone of the astragalosides. Its smallest-molecule property may be why Geron recommends it at 5 mg/day rather than astragaloside iv, which they say works fine at 50 to 100 mg/day. I also note that chitosan increases the bioavailability of astragaloside iv in standard ethanolic astragalus extracts or in astragalus extracts in glycerin prepared from these.

Edited by jamesagreen, 23 January 2008 - 04:13 PM.

Hmmm... http://en.wikipedia....#Medicinal_Uses

"Gotu Kola is a minor feature in the longevity myth of the Tai Chi Chuan master Li Ching-Yun. He purportedly lived to be 256, due in part to his usage of traditional Chinese herbs including Gotu Kola.

A popular folklore tale from Sri Lanka speaks of a prominent king from the 10th century AD named Aruna who claimed that Gotu Kola provided him with energy and stamina to satisfy his 50 woman harem."


-- I want some!!

I drank gotu kola on and off over the years. It smells very earthy but it has a medicinal taste to it. The plant grows in muddy areas, so beware dried products that have mud in them. I actually received a pound of this stuff that had dried mud in it and had to return it. I had read of the longevity and virilizing effect also, but can't vouch for the effects as I didn't die/have a lot of sex that I can remember during the times I was drinking it in substantial amounts. However I did enjoy it's calming effects on the mind without caffeine jitters. I would use gotu kola again in the future.

Hmmm... http://en.wikipedia....#Medicinal_Uses

"Gotu Kola is a minor feature in the longevity myth of the Tai Chi Chuan master Li Ching-Yun. He purportedly lived to be 256, due in part to his usage of traditional Chinese herbs including Gotu Kola.

A popular folklore tale from Sri Lanka speaks of a prominent king from the 10th century AD named Aruna who claimed that Gotu Kola provided him with energy and stamina to satisfy his 50 woman harem."


-- I want some!!

Aha, this character was cited in the Yang Hwin Ming translation of the Yi Gin Chin, bone marrow and tendon changing book from AD 500.
This is said to energise the mind and body, and win the 1001 battles in the `bedroom war'...
http://www.amazon.co...=pd_sim_b_img_5
I've practiced this strange activity for what must be over 6 years, I am more than ready to defend these claims!