Aging Theories

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Topic	Stats	Last Post Info
Comprehensive decoding of aging pathways: hypothesis of metabolic homeostasis cascade collapse convergence and re-drive Started by 南尧说生 , 29 Mar 2026 aging biology, stem cell aging and 6 more...	0 replies 163 views	南尧说生 29 Mar 2026
active sex life with heightened longevity of a eununch Started by treonsverdery , 17 Mar 2026 testosterone, eununch, sex and 4 more...	0 replies 386 views	treonsverdery 17 Mar 2026
nonsentient AI Grok's 200x more likely to live > century actual possible new drug Started by treonsverdery , 17 Mar 2026 century centenerian, centenarian and 5 more...	0 replies 167 views	treonsverdery 17 Mar 2026
Aging and thermodynamic biological age Started by albedo , 16 Jul 2023 aging theory, thermodynamics and 2 more... 1 2	Hot 43 replies 10,317 views	albedo 21 Feb 2026
Aging as an Operating System: Toward a Self-Stabilizing Biology Started by osris , 17 Feb 2026 dna repair, proteostasis and 1 more...	2 replies 411 views	osris 17 Feb 2026
Comprehensive decoding V110 Started by 南尧说生 , 17 Feb 2026 systems biology and 3 more...	0 replies 215 views	南尧说生 17 Feb 2026
Comprehensive decoding theory of aging pathway, 102nd edition Started by 南尧说生 , 07 Dec 2025 gerontology/aging biology and 4 more...	0 replies 932 views	南尧说生 07 Dec 2025
Is motor neuron loss the true biological ceiling of human lifespan? Started by Cloomis , 07 Feb 2026 aging, motor neuron, cancer and 4 more...	6 replies 632 views	osris 15 Feb 2026
Where Fedichev’s Aging Theory Meets Transcriptional Endurance Started by osris , 14 Feb 2026 rna, dna	0 replies 265 views	osris 14 Feb 2026
Comprehensive decoding of aging pathway: mitochondrial dysfunction as the primary cause of aging leading to sustained co Started by 南尧说生 , 30 Oct 2025 mitochondrion, anti-aging and 4 more...	12 replies 1,536 views	南尧说生 08 Nov 2025
Deciphering Aging: A Cascade Model from Mitochondrial First Cause to Systemic Collapse Started by 南尧说生 , 14 Oct 2025 #longecity, #antiagingresearch and 4 more...	3 replies 1,161 views	南尧说生 23 Oct 2025
The Real Pathways to Longevity Started by Cloomis , 11 Sep 2025 aging research, longevity and 7 more...	0 replies 1,398 views	Cloomis 11 Sep 2025
Genomic Failure Hypothesis Started by johnhemming , 09 Aug 2025 aging	0 replies 1,186 views	johnhemming 09 Aug 2025
A protocol to upgrade mitochondria Started by Turnbuckle , 10 Apr 2016 nicotinamide, niacin, c60, aging and 5 more... 1 2 3 7 →	Hot 183 replies 92,979 views	Fred_CALICO 03 Apr 2025
Massive scandal in Alzheimer's research just uncovered! The plaque theory was based on fraud Started by Phoebus , 24 Jul 2022 alzheimers fraud	9 replies 4,204 views	bullGenteel 20 Mar 2025
Life extension about as likely as the tooth fairy Started by Hip , 07 Jun 2023 skepticism 1 2 3	Hot 70 replies 9,383 views	osris 09 Mar 2025
Creating a unified theory of aging Started by Lazarus Long , 01 Jul 2005 1 2 3	Hot 86 replies 32,689 views	Avatar of Horus 14 Feb 2025
Breeding pet rats to live longer Started by Acetylglutathione , 23 Feb 2024 rats, breeding, aging research	4 replies 2,479 views	QuestforLife 20 Jan 2025
CD38 gets in the way of NR and NMN for increasing NAD+ Started by Michael Lustgarten , 12 Feb 2021 cd38, nad+, nmn, aging	11 replies 5,708 views	Logic 29 Dec 2024
Pathogenic Microbes: The Major Cause of Aging Started by Hip , 25 Aug 2011 pathogens, microbes, aging and 1 more... 1 2 3	Hot 87 replies 34,468 views	Logic 19 Dec 2024
Flu Shot / Vaccine & Immune Senescence Started by Dorian Grey , 05 Oct 2015 flu vaccine, flu shot 1 2	Hot 32 replies 9,765 views	albedo 13 Dec 2024
Ferrotoxic Disease: The Missing Link in Longevity? Started by Dorian Grey , 30 May 2016 iron homeostasis	2 replies 4,795 views	Dorian Grey 11 Dec 2024
My theory of ethernal lifespan updated 12/1/2021 Started by Fernando G , 01 Dec 2021 experience	1 reply 3,236 views	Fernando G 22 Oct 2024
Why are babies born young? Started by johnhemming , 06 Jun 2024 babies mitochondria	6 replies 2,293 views	johnhemming 12 Jun 2024
Asking Bing Copilot to invent new longevity drugs kind of works. (refreshing) Started by Treon Verdery , 07 Feb 2024 longevity, bing, copilot	1 reply 1,750 views	Treon Verdery 02 Mar 2024
Re-doing Hayflick's 1965 research on cell division but with modern omics Started by CynthesisToday , 26 Dec 2023 hayflick limit, senescence	2 replies 2,175 views	CynthesisToday 16 Jan 2024
Senescence and Senolytics theories based on sand? Started by Zarathrustra , 02 Mar 2022 senscence, senolytics 1 2 3	Hot 79 replies 10,485 views	osris 28 Dec 2023
Methylation showing gradual reduction in genomic function Started by johnhemming , 25 Dec 2023 epigenetics	0 replies 1,877 views	johnhemming 25 Dec 2023
Endogenous Retroviruses - a Major Cause of Senescence & Aging? Started by sub7 , 18 Aug 2019 entolimod, andrei gudkov and 3 more... 1 2 3	Hot 62 replies 15,154 views	HBRU 27 Nov 2023
Impact Of Microbes On Aging And Age-Related Disease Started by Michael Lustgarten , 07 Sep 2023 podcast, siim land	0 replies 1,983 views	Michael Lustgarten 07 Sep 2023