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Is motor neuron loss the true biological ceiling of human lifespan?

aging motor neuron cancer biomarkers biology longevity neuromuscular

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#1 Cloomis

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Posted Today, 02:40 AM


Did you know that human lifespan has a hard ceiling, not set by cancer or heart disease? Even when disease is avoided and even with perfect biomarkers, it runs into a hard biological limit —the irreversible motor neuron loss.

 

Humans are born with ~150,000 motor neurons, and lose them gradually with old age:

 

  • Before age 60, you lose ~0.5% per year 

  • After age 60, you lose ~3% per year

  • Age 75 - only ~50% functional units 

  • Age 100 - only ~20% functional units

 

At which point, frailty and neuromuscular failure dominate death. And once it begins to fail, no amount of optimization or lifestyle change can fully compensate.

 

Read the full article to know more.







Also tagged with one or more of these keywords: aging, motor neuron, cancer, biomarkers, biology, longevity, neuromuscular

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