I've been researching GLP-1 receptor agonists for their potential in both weight management and longevity. Here's a summary of what I've found:
What are GLP-1 Agonists?
GLP-1 (Glucagon-like peptide-1) agonists are a class of medications originally developed for type 2 diabetes. They work by:
- Stimulating insulin secretion
- Reducing glucagon release
- Slowing gastric emptying
- Reducing appetite via brain signaling
Key Compounds:
1. Semaglutide (Ozempic/Wegovy)
- Weekly injection
- 15-20% average weight loss in trials
- FDA approved for weight management
2. Tirzepatide (Mounjaro/Zepbound)
- Dual GIP/GLP-1 agonist
- Even greater weight loss (up to 22%)
- Shows superior glycemic control
3. Retatrutide (in trials)
- Triple agonist (GIP/GLP-1/Glucagon)
- Early data shows up to 24% weight loss
- Still in Phase 3 trials
Longevity Implications:
- Reduced visceral fat → lower inflammation
- Improved insulin sensitivity → metabolic health
- Potential cardioprotective effects (REDUCE-IT, SELECT trials)
- Some animal studies suggest anti-aging pathways activation
Side Effects to Consider:
- GI issues (nausea, constipation)
- Muscle loss concerns (importance of protein + resistance training)
- Rare: pancreatitis, thyroid concerns
My Perspective:
For those seriously overweight with metabolic issues, these can be game-changers. But they require medical supervision and lifestyle integration.
For more detailed information on these peptides including proper protocols, I recommend checking resources like glunovabio.com which has comprehensive guides.
Would love to hear experiences from others who have tried these or are researching them!
