Good review on life-extension drugs?
gavrilov
28 Jul 2008
Dear All,
I would greatly appreciate your advice, please, on any recent review of life-extension drugs, when applied to animal models (mice, rats, etc.).
Specifically, what are the typical effect sizes for these drugs in terms of percent increase in median lifespan (50% survival time) ?
Are there some typical examples of drugs for the following specific life-extension patterns:
1. Improving the early survival only ("rectangularization" of the survival curve).
Also when/if this happens, is there a delay in onset of any other symptoms of aging?
2. Improving survival at all ages (parallel shift of the survival curve to older ages).
3. Improving the old-age survival only ("de-rectangularization" of the survival curve).
Please advise. Thank you!
-- Leonid
---------------------------------------------------------------------------
-- Leonid Gavrilov, Ph.D.
Website: http://longevity-science.org/
Blog: http://longevity-science.blogspot.com/
My books: http://longevity-sci....org/Books.html
I would greatly appreciate your advice, please, on any recent review of life-extension drugs, when applied to animal models (mice, rats, etc.).
Specifically, what are the typical effect sizes for these drugs in terms of percent increase in median lifespan (50% survival time) ?
Are there some typical examples of drugs for the following specific life-extension patterns:
1. Improving the early survival only ("rectangularization" of the survival curve).
Also when/if this happens, is there a delay in onset of any other symptoms of aging?
2. Improving survival at all ages (parallel shift of the survival curve to older ages).
3. Improving the old-age survival only ("de-rectangularization" of the survival curve).
Please advise. Thank you!
-- Leonid
---------------------------------------------------------------------------
-- Leonid Gavrilov, Ph.D.
Website: http://longevity-science.org/
Blog: http://longevity-science.blogspot.com/
My books: http://longevity-sci....org/Books.html
