Small Cell Lung Cancer, Drugs and Supplements
tham 27 Dec 2008
Two drugs which have established anticachexia activity
in cancer, HIV and aging.
1. Thalidomide
2. Pentoxifylline
Thalidomide has powerful TNF-alpha inhibiting and
antiangiogenesis properties. Anticachexic and direct
cancer activity.
Trials in SCLC inconclusive, but appears to be responsible
for remission at least one anecdotal case.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://annonc.oxford...eprint/10/7/857
in cancer, HIV and aging.
1. Thalidomide
2. Pentoxifylline
Thalidomide has powerful TNF-alpha inhibiting and
antiangiogenesis properties. Anticachexic and direct
cancer activity.
Trials in SCLC inconclusive, but appears to be responsible
for remission at least one anecdotal case.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://annonc.oxford...eprint/10/7/857
tham 27 Dec 2008
Pentoxifylline (Trental) inhibits TNF alpha, IL-1 and IL-6,
leading to its application in a host of diseases other than
its usual use in intermittent claudication.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
Megestrol acetate :
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
Medroxyprogestrone, Celebrex, antioxidants, PUFAs in NSCLC.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
leading to its application in a host of diseases other than
its usual use in intermittent claudication.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
Megestrol acetate :
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
Medroxyprogestrone, Celebrex, antioxidants, PUFAs in NSCLC.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
sponsored ad
tham 30 Dec 2008
Updated protocol for SCLC.
1. Amrubucin
2. Topotecan
3. Imatinib
4. Zoledrenate
5. Vitamin K2 as MK4
6. Solifenacin or darifenacin
7. Simvastatin
8. Thalidomide or pentoxifylline
9. Sulindac sulfone or indomethacin
Indomethacin. Note that this potent old NSAID will
cause gastric ulcers, so must be taken with a H2
blocker like cimetidine or proton pump inhibitor like
omeprazole.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
Sulindac sulfone (exisulind, Atopsyn)) is the second metabolite
of the old NSAID, sulindac (Clinoril). The first metabolite,
sulindac sulfide, blocks Cox-1 and is primarily responsible
for its antiinflammatory action, but severe gastric distress.
Initial use of it was in prostate cancer.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.pslgroup.com/dg/20329E.htm
1. Amrubucin
2. Topotecan
3. Imatinib
4. Zoledrenate
5. Vitamin K2 as MK4
6. Solifenacin or darifenacin
7. Simvastatin
8. Thalidomide or pentoxifylline
9. Sulindac sulfone or indomethacin
Indomethacin. Note that this potent old NSAID will
cause gastric ulcers, so must be taken with a H2
blocker like cimetidine or proton pump inhibitor like
omeprazole.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
Sulindac sulfone (exisulind, Atopsyn)) is the second metabolite
of the old NSAID, sulindac (Clinoril). The first metabolite,
sulindac sulfide, blocks Cox-1 and is primarily responsible
for its antiinflammatory action, but severe gastric distress.
Initial use of it was in prostate cancer.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.pslgroup.com/dg/20329E.htm
tham 31 Dec 2008
NSCLC overexpresses COX-2, but not SCLC.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
That is why one can't find any studies on the therapeutic
activity of C0X-2 inhibitors, particularly celecoxib (Celebrex),
against SCLC, while there are lots against NSCLC.
Indomethacin's and exisulind's (sulindac sulfone) activity against
SCLC are apparently by pathways other than COX-1 or COX-2. One
pathway is the peroxisome proliferator-activated receptor (PPAR),
currently under intensive investigation.
Exisulind also inhibits CGMP-PDE.
http://news.bio-medi...athway-11708-3/
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
Sulindac sulfide inhibits both C0X-1 and COX-2, but its
efficacy against SCLC appears to be vide PPAR gamma.
However, gastric ulceration due to heavy C0X-1 inhibition
is an adverse effect, and means that you should go on
antiulcer medication at the same time.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
Phase 2 trial of exisulind (Aptosyn) with standard chemo
against SCLC was disappointing though.
http://www.asco.org/...bstractID=34212
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
That is why one can't find any studies on the therapeutic
activity of C0X-2 inhibitors, particularly celecoxib (Celebrex),
against SCLC, while there are lots against NSCLC.
Indomethacin's and exisulind's (sulindac sulfone) activity against
SCLC are apparently by pathways other than COX-1 or COX-2. One
pathway is the peroxisome proliferator-activated receptor (PPAR),
currently under intensive investigation.
Exisulind also inhibits CGMP-PDE.
http://news.bio-medi...athway-11708-3/
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
Sulindac sulfide inhibits both C0X-1 and COX-2, but its
efficacy against SCLC appears to be vide PPAR gamma.
However, gastric ulceration due to heavy C0X-1 inhibition
is an adverse effect, and means that you should go on
antiulcer medication at the same time.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
Phase 2 trial of exisulind (Aptosyn) with standard chemo
against SCLC was disappointing though.
http://www.asco.org/...bstractID=34212
tham 02 Jan 2009
Bill -
If you can swallow some fluids, start on one of these immediately.
20 drops daily for 1,000 mcg of selenite :
http://www.vrp.com/P...spx?ProdID=7800
Or two tablespoonfuls of this for 1,200 mcg :
http://www.betterlif...sp?prod_id=8933
Of just 4 tiny caps of this for 1,000 mcg, if you can get
them past your esophagus :
http://www.betterlif...sp?prod_id=1060
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
If you can swallow some fluids, start on one of these immediately.
20 drops daily for 1,000 mcg of selenite :
http://www.vrp.com/P...spx?ProdID=7800
Or two tablespoonfuls of this for 1,200 mcg :
http://www.betterlif...sp?prod_id=8933
Of just 4 tiny caps of this for 1,000 mcg, if you can get
them past your esophagus :
http://www.betterlif...sp?prod_id=1060
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
thefirstimmortal 02 Jan 2009
LOL, Tham, I generally don't do anything "immediately".Bill -
If you can swallow some fluids, start on one of these immediately.
20 drops daily for 1,000 mcg of selenite :
http://www.vrp.com/P...spx?ProdID=7800
Selenium is on my vity routine, liquid form drops, first link looked like a good substitute. I'll log that in for whenever I get around to the next ordering round, which should be soon, although not "immediately".
20 drops??? According to one of the links you supplies, it says, "Do not exceed 400 micrograms of selenium per day from all sources." Why do you think 20 drops daily for 1,000 mcg of selenite is good?
Also, this is stuff that you might want to post about in my fighting cancer thread.
tham 03 Jan 2009
Bill !!! Thought you knew enough about life extension, and about
selenium's way overrated toxicity as well, to realize the last thing
that life extensionists follow is what is written on the supplement
labelling, let alone restrict themselves to such overcautious
dosages when they are fighting a life-threatening disease ?
And that sodium selenite is the way to go when fighting cancer,
not selenomethonine, selenium yeast or even Se-MSC ?
I emphasized that when making one of my first posts in Minni's
thread.
http://www.imminst.o...o...st&p=274089
At least 1,000 mcg of selenite should have been the FIRST
on your list. I wish I knew that 12 years ago when advising
the lady from one of our branch officers, who had aggressive
lung adenocarcinoma, to take only a paltry 200 mcg, and
moreover a weakling like selenomethionine at that.
"400 mcg of selenium from all sources" is a maintenance dosage
for someone in good health. You're fighting one of the most
aggressive cancers around - how is, say 100 mcg from your diet
(which is even unlikely given your current state of malnutrition), and
another 300 mcg from supplements even going to fight a kitten ?
Even if toxicity comes in (at least five times that), it's easily
recognizable (hair loss, brittle nails, garlicky breath, metallic
taste in mouth, etc), reversible and of no consequence.
Compared to the heavyweight chemo drugs you have been
on so far, it's like a chimpanzee to King Kong.
http://www.ncbi.nlm....l=pubmed_docsum
http://72.14.235.132...R...;cd=8&gl=my
http://linkinghub.el...306987704005791
When I contacted Julian Spallholz of Texas Tech University some
time ago enquiring whether 2,000 mcg of selenite was OK to
add to a cancer protocol, he said it was good.
Alternative cancer centers in Mexico routinely give up to
2,000 mcg at least the yeast form to cancer patients.
From Leslie Kenton's book, "Ageless Aging", 1986,
which I still keep on my office shelf :
"Its power against cancer is of particular interest to anyone
about retarding the ageing process, since so many of the
changes on a cellular level associated with the development
of cancer are paralleled in cellular ageing."
" Selenium's role in glutathione peroxidase activity and its ability
to detoxify the body of carcinogens are no doubt in its important
in its ability to protect from cancer and to retard the ageing
process. But so too is the direct action it has on the immune
system - improving immune functions as NO OTHER single
nutrient appears able to do. " (Selenium upregulates NK cells.)
"Most nutritionists err on the side of caution and recommend
200 mcg despite the fact that the Japanese take in much more
than twice that in their daily diet and appear to get nothing but
benefits from it. " (Japanese fishermen, especially those from
Okinawa, take in AT LEAST 500 - 600 mcg daily.)
"Chronic selenium toxicity would be expected in human beings
after LONG TERM consumption of 2,400 to 3,000 mcg daily."
"Most longevists take a MINIMUM of 400 mcg a day and a few
go as high as 2,000 mcg."
http://www.stda.net/...ons/B2000-2.pdf
I posted here because this is specifically about SCLC.
Secondly, your "Fighting Cancer" thread is getting quite
long and cluttered.
If I were you, I'd start on the selenite IMMEDIATELY.
http://www.imminst.o...showtopic=20151
selenium's way overrated toxicity as well, to realize the last thing
that life extensionists follow is what is written on the supplement
labelling, let alone restrict themselves to such overcautious
dosages when they are fighting a life-threatening disease ?
And that sodium selenite is the way to go when fighting cancer,
not selenomethonine, selenium yeast or even Se-MSC ?
I emphasized that when making one of my first posts in Minni's
thread.
http://www.imminst.o...o...st&p=274089
At least 1,000 mcg of selenite should have been the FIRST
on your list. I wish I knew that 12 years ago when advising
the lady from one of our branch officers, who had aggressive
lung adenocarcinoma, to take only a paltry 200 mcg, and
moreover a weakling like selenomethionine at that.
"400 mcg of selenium from all sources" is a maintenance dosage
for someone in good health. You're fighting one of the most
aggressive cancers around - how is, say 100 mcg from your diet
(which is even unlikely given your current state of malnutrition), and
another 300 mcg from supplements even going to fight a kitten ?
Even if toxicity comes in (at least five times that), it's easily
recognizable (hair loss, brittle nails, garlicky breath, metallic
taste in mouth, etc), reversible and of no consequence.
Compared to the heavyweight chemo drugs you have been
on so far, it's like a chimpanzee to King Kong.
http://www.ncbi.nlm....l=pubmed_docsum
Sodium selenite remains a critical component
of our cancer and leukemia treatment protocols.
The dose is one milligram per day, or five 200
microgram pills over the course of a day. This
dose of selenite is not toxic in humans.
http://72.14.235.132...R...;cd=8&gl=my
http://linkinghub.el...306987704005791
When I contacted Julian Spallholz of Texas Tech University some
time ago enquiring whether 2,000 mcg of selenite was OK to
add to a cancer protocol, he said it was good.
Alternative cancer centers in Mexico routinely give up to
2,000 mcg at least the yeast form to cancer patients.
From Leslie Kenton's book, "Ageless Aging", 1986,
which I still keep on my office shelf :
"Its power against cancer is of particular interest to anyone
about retarding the ageing process, since so many of the
changes on a cellular level associated with the development
of cancer are paralleled in cellular ageing."
" Selenium's role in glutathione peroxidase activity and its ability
to detoxify the body of carcinogens are no doubt in its important
in its ability to protect from cancer and to retard the ageing
process. But so too is the direct action it has on the immune
system - improving immune functions as NO OTHER single
nutrient appears able to do. " (Selenium upregulates NK cells.)
"Most nutritionists err on the side of caution and recommend
200 mcg despite the fact that the Japanese take in much more
than twice that in their daily diet and appear to get nothing but
benefits from it. " (Japanese fishermen, especially those from
Okinawa, take in AT LEAST 500 - 600 mcg daily.)
"Chronic selenium toxicity would be expected in human beings
after LONG TERM consumption of 2,400 to 3,000 mcg daily."
"Most longevists take a MINIMUM of 400 mcg a day and a few
go as high as 2,000 mcg."
http://www.stda.net/...ons/B2000-2.pdf
I posted here because this is specifically about SCLC.
Secondly, your "Fighting Cancer" thread is getting quite
long and cluttered.
If I were you, I'd start on the selenite IMMEDIATELY.
http://www.imminst.o...showtopic=20151
davidd 05 Jan 2009
Wow, Tham, what a bunch of wonderful information you are providing here and other places on the site. It is people like you who make this site a source of top notch knowledge.
Keep up the good work!
You know what I would find interesting? A thread where you share anecdotal information on people you treat and what works/doesn't work.
*note to self* -- put selenium on the list of "things to try"
David
Keep up the good work!
You know what I would find interesting? A thread where you share anecdotal information on people you treat and what works/doesn't work.
*note to self* -- put selenium on the list of "things to try"
David
tham 06 Jan 2009
Thank you for the kind comments, David.
Unfortunately, I am unable provide any anecdotal reports of
people whom I have "treated".
This is because I have never really "treated" anyone. I'm just a
mundane pen-pusher in an office whose career has never really
taken off. (I compute corporate and personal income taxes.)
I just surf Medline during my spare time. I've had more of
a lifelong interest in defence rather than life extension,
and was actually interviewed in 1995 by Najib, the local
Defence Minister at that time (after a few letters to him
about the country's air defence), currently the Deputy Prime
Minister and on his way to the number one post in March.
Recently I've taken up an interest in medical astrology. The
info about selenium and HIV which I mentioned in the link
above that I had posted elsewhere earlier, was actually in
an astrology forum.
The people in my office joke that my "patients" (people whom
I advise occasionally on cutting-edge supplements for diseaseas)
have a ZERO survival rate. This is largely due to the fact that
many of them are terminal cancer patients.
This included, in 1996, the disheartening case of the lady with
aggressive lung adenocarcinoma (NSCLC) in another town, when
I had no access to the net and didn't know enough about fighting
cancer at that time.
I advised her to take 15 grams of vitamin C powder after reading
about the work of Linus Pauling and Ewan Cameron.
Abram Hoffer in Canada was kind enough to fax me his protocol
at that time, when I faxed him requesting for it. I ordered the
supplements from the US for her, and she took it.
Hoffer's protocol :
Daily :
25,000 iu beta carotene
One B-50 complex
800 iu vitamin E as tocopherol succinate
1,500 mg niacinamide or inositol hexaniacinate
300 to 600 mg coenzyme Q10
25 mg melatonin at bedtime
600 mcg selenium
I made the mistake of getting selenomethionine for her,
instead of sodium selenite. Moreover, I ordered 50 mcg
tabs. She took just four a day - basically useless.
As she was in another town, I described her appearance,
personality and symptoms to my homeopathic doctor,
who arrived at her remedy picture, and I mailed the
remedies to her. Like many in this forum, she was quite
naive about homeopathy and had little faith in it. I believe
she never did take the remedies.
Her oncologist gave her a prognosis of about a year.
She managed to make it to about a year and a half
after she developed brain metastases.
Unfortunately, I am unable provide any anecdotal reports of
people whom I have "treated".
This is because I have never really "treated" anyone. I'm just a
mundane pen-pusher in an office whose career has never really
taken off. (I compute corporate and personal income taxes.)
I just surf Medline during my spare time. I've had more of
a lifelong interest in defence rather than life extension,
and was actually interviewed in 1995 by Najib, the local
Defence Minister at that time (after a few letters to him
about the country's air defence), currently the Deputy Prime
Minister and on his way to the number one post in March.
Recently I've taken up an interest in medical astrology. The
info about selenium and HIV which I mentioned in the link
above that I had posted elsewhere earlier, was actually in
an astrology forum.
The people in my office joke that my "patients" (people whom
I advise occasionally on cutting-edge supplements for diseaseas)
have a ZERO survival rate. This is largely due to the fact that
many of them are terminal cancer patients.
This included, in 1996, the disheartening case of the lady with
aggressive lung adenocarcinoma (NSCLC) in another town, when
I had no access to the net and didn't know enough about fighting
cancer at that time.
I advised her to take 15 grams of vitamin C powder after reading
about the work of Linus Pauling and Ewan Cameron.
Abram Hoffer in Canada was kind enough to fax me his protocol
at that time, when I faxed him requesting for it. I ordered the
supplements from the US for her, and she took it.
Hoffer's protocol :
Daily :
25,000 iu beta carotene
One B-50 complex
800 iu vitamin E as tocopherol succinate
1,500 mg niacinamide or inositol hexaniacinate
300 to 600 mg coenzyme Q10
25 mg melatonin at bedtime
600 mcg selenium
I made the mistake of getting selenomethionine for her,
instead of sodium selenite. Moreover, I ordered 50 mcg
tabs. She took just four a day - basically useless.
As she was in another town, I described her appearance,
personality and symptoms to my homeopathic doctor,
who arrived at her remedy picture, and I mailed the
remedies to her. Like many in this forum, she was quite
naive about homeopathy and had little faith in it. I believe
she never did take the remedies.
Her oncologist gave her a prognosis of about a year.
She managed to make it to about a year and a half
after she developed brain metastases.
tham 08 Jan 2009
Nexavar, as mentioned and being taken by Larry (Ptbone) in the
"Fighting Cancer" thread, also looks very promising for SCLC.
Abbott's new drug, ABT-737, targets three members of the
Bcl-2 family of antiapoptotic genes - Bcl-2, Bcl-xL and Bcl-w,
but not Mcl-1. This lack of action against Mcl-1 is a possible
cause of failure of ABT-737 in SCLC.
http://www.businessw...50/b3963151.htm
http://www.nature.co...ature03579.html
http://www.xagena.it...9bb6504a68.html
http://en.wikipedia.org/wiki/Mcl-1
BAY 43-9006 is sorafenib (Nexavar) and inhibits Mcl-1.
Combining it with ABT-737 reverses resistance in SCLC :
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://cancerres.aac...stract/67/2/782
http://www.scienceda...61117121634.htm
Ongoing trials of sorafenib in SCLC. The three remaining
recruiting trials all exclude swallowing, malabsorption and
cardiac problems, but no harm enquiring if you still qualify.
http://clinicaltrial...sorafenib sclc
Edited by tham, 08 January 2009 - 06:09 PM.
"Fighting Cancer" thread, also looks very promising for SCLC.
Abbott's new drug, ABT-737, targets three members of the
Bcl-2 family of antiapoptotic genes - Bcl-2, Bcl-xL and Bcl-w,
but not Mcl-1. This lack of action against Mcl-1 is a possible
cause of failure of ABT-737 in SCLC.
http://www.businessw...50/b3963151.htm
http://www.nature.co...ature03579.html
http://www.xagena.it...9bb6504a68.html
http://en.wikipedia.org/wiki/Mcl-1
BAY 43-9006 is sorafenib (Nexavar) and inhibits Mcl-1.
Combining it with ABT-737 reverses resistance in SCLC :
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://cancerres.aac...stract/67/2/782
http://www.scienceda...61117121634.htm
Ongoing trials of sorafenib in SCLC. The three remaining
recruiting trials all exclude swallowing, malabsorption and
cardiac problems, but no harm enquiring if you still qualify.
http://clinicaltrial...sorafenib sclc
Edited by tham, 08 January 2009 - 06:09 PM.
Proconsul 08 Jan 2009
This is one of the latest studies about Selenium toxicity:
Kamble P, Mohsin N, Jha A, Date A, Upadhaya A, Mohammad E, Khalil M, Pakkyara A, Budruddin M. Selenium intoxication with selenite broth resulting in acute renal failure and severe gastritis. Saudi J Kidney Dis Transpl [serial online] 2009 [cited 2009 Jan 8];20:106-11. Available from: http://www.sjkdt.org.../20/1/106/44715
I quote some relevant passages:
Selenium (Se) is an ubiquitous element which is essential to the human organism and is also widely utilized in industrial processes. As an essential trace element, it plays an important role in many biochemical and physiological pathways, particularly in the activation of glutathione peroxidase (an enzyme involved in preventing oxidative damage of the cells). [1] It has been used in cancer patients to improve nutritional and immunological status. Also, it has been shown to have a protective role in preventing liver cancer and nuclear cataract. [2],[3],[4],[5]
Despite its beneficial effects, excessive doses of this element result in intoxication. Cases of acute Se intoxication occur due to excessive industrial exposure, overdose in demented patients or suicidal patients and in toddlers. Depending on the quantity and the form, symptoms and signs may vary and include excessive salivation, garlicky breath odor, nausea, vomiting, abdominal pain, ta­chycardia, hematemesis, necrosis of the liver and the kidneys, cerebral and pulmonary edema, coma and death. Currently, there are no known antidotes and the treatment remains mainly symptomatic and supportive. [6]
.....
Selenium (Se) is an essential dietary trace element with anti-oxidant properties due to its role in activation of glutathione peroxidase, an enzyme involved in preventing oxidative damage to cells. It also plays an important role in many biochemical and physiological processes including the biosynthesis of co­enzyme Q (a component of mitochondrial electron transport system), regulation of the ion fluxes across membranes, maintenance of integrity of keratins and stimulation of anti­body synthesis. [1] There is some evidence sug­gesting that adequate dietary supplementation of Se may provide protection against some cancers. Se is currently used in hyperalimen­tation and total parenteral nutrition. [7],[8]
There appears to be a relatively narrow range between levels of Se intake resulting in deficiency and those causing toxicity. [9] The recommended daily allowance (RDA), for adults, by the Federal Drug Administration (FDA) is 50-200 µg.
Kamble P, Mohsin N, Jha A, Date A, Upadhaya A, Mohammad E, Khalil M, Pakkyara A, Budruddin M. Selenium intoxication with selenite broth resulting in acute renal failure and severe gastritis. Saudi J Kidney Dis Transpl [serial online] 2009 [cited 2009 Jan 8];20:106-11. Available from: http://www.sjkdt.org.../20/1/106/44715
I quote some relevant passages:
Selenium (Se) is an ubiquitous element which is essential to the human organism and is also widely utilized in industrial processes. As an essential trace element, it plays an important role in many biochemical and physiological pathways, particularly in the activation of glutathione peroxidase (an enzyme involved in preventing oxidative damage of the cells). [1] It has been used in cancer patients to improve nutritional and immunological status. Also, it has been shown to have a protective role in preventing liver cancer and nuclear cataract. [2],[3],[4],[5]
Despite its beneficial effects, excessive doses of this element result in intoxication. Cases of acute Se intoxication occur due to excessive industrial exposure, overdose in demented patients or suicidal patients and in toddlers. Depending on the quantity and the form, symptoms and signs may vary and include excessive salivation, garlicky breath odor, nausea, vomiting, abdominal pain, ta­chycardia, hematemesis, necrosis of the liver and the kidneys, cerebral and pulmonary edema, coma and death. Currently, there are no known antidotes and the treatment remains mainly symptomatic and supportive. [6]
.....
Selenium (Se) is an essential dietary trace element with anti-oxidant properties due to its role in activation of glutathione peroxidase, an enzyme involved in preventing oxidative damage to cells. It also plays an important role in many biochemical and physiological processes including the biosynthesis of co­enzyme Q (a component of mitochondrial electron transport system), regulation of the ion fluxes across membranes, maintenance of integrity of keratins and stimulation of anti­body synthesis. [1] There is some evidence sug­gesting that adequate dietary supplementation of Se may provide protection against some cancers. Se is currently used in hyperalimen­tation and total parenteral nutrition. [7],[8]
There appears to be a relatively narrow range between levels of Se intake resulting in deficiency and those causing toxicity. [9] The recommended daily allowance (RDA), for adults, by the Federal Drug Administration (FDA) is 50-200 µg.
tham 09 Jan 2009
" ..... it was revealed that the patient had "accidentally"
consumed about 100 mL of selenite broth from a local
hospital laboratory, one day prior to her hospital admission. "
" It was calculated that the patient under discussion
consumed about 400 mg of sodium selenite. "
400 MG = 400,000 MCG
" ..... a two-year-old male child presented with severe corrosive
gastritis and moderate renal, hepatic and pulmonary dysfunction
after consuming 15 mL of GunBlue solution containing selenious acid. "
Gun Blue usually contains 2 % selenious acid.
15 ML = 0.3 to 0.6 ML = APPROX. 0.3 GRAMS = 300 MG
" In another instance, where the patient presented after
fatal suicidal ingestion of Gun-Blue solution. "
" 7.2.1.1 -
A 30-60 ml ingestion of gun blue (2 % selenious acid)
resulted in death (Pentel et al., 1985). "
http://www.inchem.or...i... Human data
30 - 60 ML @ 2% = 0.6 to 1.2 ML = APPROX. 600 to 1,200 MG
tham 10 Jan 2009
tham 13 Jan 2009
tham 13 Jan 2009
Talk to Jeff Young, I'm sure a major hospital like the
one you are in has Cyberknife or Trilogy.
As Mind and FunkOddysey pointed out, I'm sure those machines
can cut away at least a portion of the tumor around your heart
and esophagus.
Trilogy appears to have the edge over Cyberknife for SCLC,
but no harm checking both out.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.cyberknif...f...f=6&m=15657
http://www.cyberknif...f...?f=6&m=9091
The Trilogy system claims to be the most advanced, versatile
and precise in the world, able to pinpoint the beam down to
0.4 mm, compared to 0.7 mm with Cyberknife.
Its versatility includes its speed, which takes about 20 minutes
for each treatment, while Cyberknife requires an hour or so.
http://www.trcc.org/...y/trilogy1.html
http://www.lifespan....iation/trilogy/
This Malaysian cancer center has installed it and
is treating some 20 patients a day.
http://www.nci.com.my/
However, the Trilogy system does not appear to use
a robot and is incapable of tracking organs in motion
(when breathing, etc), something Cyberknife's robot,
which reputedly uses cruise missile technology, can.
Cyberknife costs about $5 million, Trilogy $3 million.
http://www.cyberknif...f...?f=7&m=4815
http://atlanta.bizjo.../01/story7.html
The Trilogy machine cannot track the tumor in real time,
but this center uses an auxiliary infrared imaging device
to do this, seconds before the Trilogy machine shoots the
radiation beam. The system is called IGRT, or Image-Guided
Radiotherapy.
However, I believe such a device would result in
additional radiation hazard (2 kV) to the patient.
http://www.massey.vc.../patientqa.html
The infrared tracker, called ExacTrac, is described here :
http://www.exactrac-igrt.com/
http://www.ncbi.nlm....l=pubmed_docsum
http://www.imagingec..._2007-07_04.asp
http://www.medicalne...cles/123943.php
http://www.rt-image....769A724488B0441
http://www.roswellpa...Therapy/Trilogy
http://www.roswellpa...ep(2007)-US.pdf
http://www.redorbit....y_of/index.html
http://www.varian.co...cer_center.html
one you are in has Cyberknife or Trilogy.
As Mind and FunkOddysey pointed out, I'm sure those machines
can cut away at least a portion of the tumor around your heart
and esophagus.
Trilogy appears to have the edge over Cyberknife for SCLC,
but no harm checking both out.
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.cyberknif...f...f=6&m=15657
http://www.cyberknif...f...?f=6&m=9091
The Trilogy system claims to be the most advanced, versatile
and precise in the world, able to pinpoint the beam down to
0.4 mm, compared to 0.7 mm with Cyberknife.
Its versatility includes its speed, which takes about 20 minutes
for each treatment, while Cyberknife requires an hour or so.
http://www.trcc.org/...y/trilogy1.html
http://www.lifespan....iation/trilogy/
This Malaysian cancer center has installed it and
is treating some 20 patients a day.
http://www.nci.com.my/
However, the Trilogy system does not appear to use
a robot and is incapable of tracking organs in motion
(when breathing, etc), something Cyberknife's robot,
which reputedly uses cruise missile technology, can.
Cyberknife costs about $5 million, Trilogy $3 million.
http://www.cyberknif...f...?f=7&m=4815
http://atlanta.bizjo.../01/story7.html
The Trilogy machine cannot track the tumor in real time,
but this center uses an auxiliary infrared imaging device
to do this, seconds before the Trilogy machine shoots the
radiation beam. The system is called IGRT, or Image-Guided
Radiotherapy.
However, I believe such a device would result in
additional radiation hazard (2 kV) to the patient.
http://www.massey.vc.../patientqa.html
The infrared tracker, called ExacTrac, is described here :
http://www.exactrac-igrt.com/
http://www.ncbi.nlm....l=pubmed_docsum
http://www.imagingec..._2007-07_04.asp
http://www.medicalne...cles/123943.php
http://www.rt-image....769A724488B0441
http://www.roswellpa...Therapy/Trilogy
http://www.roswellpa...ep(2007)-US.pdf
http://www.redorbit....y_of/index.html
http://www.varian.co...cer_center.html
tham 14 Jan 2009
AT-101, gossypol (cottonseed oil) derivative.
http://clinicaltrial...erm=at-101 sclc
http://meeting.ascop...l...ar=&hits=20
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.bioscreen...ssary/gossypol/
http://sci.tech-arch...1/msg00032.html
Edited by tham, 14 January 2009 - 04:55 PM.
http://clinicaltrial...erm=at-101 sclc
http://meeting.ascop...l...ar=&hits=20
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.bioscreen...ssary/gossypol/
http://sci.tech-arch...1/msg00032.html
Edited by tham, 14 January 2009 - 04:55 PM.
tham 14 Jan 2009
tham 17 Jan 2009
Temsirolimus :
http://meeting.ascop...ourcetype=HWCIT
Sagopilone :
http://meeting.ascop...ourcetype=HWCIT
http://www.research....pothilones.aspx
http://www.manufactu.......e=54451&c=1
http://clinicaltrial...075...e"&rank=7
Ixabepilone :
http://meeting.ascop...ourcetype=HWCIT
http://meeting.ascop...ourcetype=HWCIT
http://meeting.ascop...ourcetype=HWCIT
Sagopilone :
http://meeting.ascop...ourcetype=HWCIT
http://www.research....pothilones.aspx
http://www.manufactu.......e=54451&c=1
http://clinicaltrial...075...e"&rank=7
Ixabepilone :
http://meeting.ascop...ourcetype=HWCIT
http://meeting.ascop...ourcetype=HWCIT
tham 19 Jan 2009
tham 20 Jan 2009
The new Bcl2 inhibitor, obatoclax, looks very promising.
Lung cancer tends to overexpress Bcl2 genes, the major
ones of which are Bcl2, Bcl-xL, Bcl-w and Mcl1, the latter
which is particularly dominant in SCLC.
Abbott's ABT737 inhibits the first three, but not Mcl1,
requiring combination with an Mcl1 inhibitor like sorafenib
for treatment response.
http://www.imminst.o...o...st&p=290461
Obatoclax inhibits all four genes.
Lung cancer tends to overexpress Bcl2 genes, the major
ones of which are Bcl2, Bcl-xL, Bcl-w and Mcl1, the latter
which is particularly dominant in SCLC.
Abbott's ABT737 inhibits the first three, but not Mcl1,
requiring combination with an Mcl1 inhibitor like sorafenib
for treatment response.
http://www.imminst.o...o...st&p=290461
Obatoclax inhibits all four genes.
tham 20 Jan 2009
If you have had the standard 5-day schedule at 1.5 mg/m2/day
of topotecan, revising it to a 4mg/m2/week over 12 weeks might
improve your response :
http://meeting.ascop...ourcetype=HWCIT
of topotecan, revising it to a 4mg/m2/week over 12 weeks might
improve your response :
http://meeting.ascop...ourcetype=HWCIT
tham 20 Jan 2009
Sorafenib on patients pretreated with cisplatin/carboplatin.
http://meeting.ascop...ourcetype=HWCIT
Witht the proteasome inhibitor, bortezomib.
http://meeting.ascop...ourcetype=HWCIT
http://meeting.ascop...ourcetype=HWCIT
Witht the proteasome inhibitor, bortezomib.
http://meeting.ascop...ourcetype=HWCIT
tham 20 Jan 2009
AT-101, gossypol (cottonseed oil) derivative.
http://clinicaltrial...erm=at-101 sclc
http://meeting.ascop...l...ar=&hits=20
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.bioscreen...ssary/gossypol/
http://sci.tech-arch...1/msg00032.html
Note that the gossypol analog, AT-101, also blocks
all four Bcl2 genes.
http://meeting.ascop...ourcetype=HWCIT
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
http://www.ncbi.nlm....l=pubmed_docsum
tham 27 Jan 2009
tham 09 Feb 2009
tham 14 Feb 2009
Defibrotide, ticlopidine (Ticlid).
http://www.ncbi.nlm....l=pubmed_docsum
http://en.wikipedia....iki/Defibrotide
Monoclonal antibody + BCG.
BEC2 = Mitumomab.
http://www.ncbi.nlm....l=pubmed_docsum
http://professional....ancerType=35532
Edited by tham, 14 February 2009 - 08:02 PM.
http://www.ncbi.nlm....l=pubmed_docsum
http://en.wikipedia....iki/Defibrotide
Monoclonal antibody + BCG.
BEC2 = Mitumomab.
http://www.ncbi.nlm....l=pubmed_docsum
http://professional....ancerType=35532
Edited by tham, 14 February 2009 - 08:02 PM.
tham 16 Feb 2009
Current Japanese Phase 2 trial on PSK with cisplatin and irinotecan.
http://clinicaltrial...how/NCT00546130
http://clinicaltrial...how/NCT00546130
tham 17 Feb 2009
If you look again at this study on both NSCLC and SCLC :
" ..... PPAR-gamma is so important in the pathogenesis and/or progression of
lung cancer that it may be a novel therapeutical target against lung cancer. "
http://www.ncbi.nlm....l=pubmed_docsum
Stop resveratrol for the moment, and get Can Ilyas to start you on
15 mg of Actos (pioglitazone) ASAP. Ground each tablet into powder
and gulp it down with some water.
http://www.actos.com
http://www.drugs.com...es/P05334A1.jpg
http://www.kmhk.kmu......tos 30mg2.jpg
http://www.hindawi.c...1155/2007/90289
http://www.hindawi.c...i...4165&e=html
" ..... PPAR-gamma is so important in the pathogenesis and/or progression of
lung cancer that it may be a novel therapeutical target against lung cancer. "
http://www.ncbi.nlm....l=pubmed_docsum
Stop resveratrol for the moment, and get Can Ilyas to start you on
15 mg of Actos (pioglitazone) ASAP. Ground each tablet into powder
and gulp it down with some water.
http://www.actos.com
http://www.drugs.com...es/P05334A1.jpg
http://www.kmhk.kmu......tos 30mg2.jpg
http://www.hindawi.c...1155/2007/90289
http://www.hindawi.c...i...4165&e=html
tham 18 Feb 2009
In the above study, caspase-3 is one of the key enzymes
in the PPAR gamma signalling pathway.
" The caspase-3 level was positively correlated with the level
of apoptosis . "
" Caspase 3 has been called the "henchman that goes around
and executes the cell. "
http://www.medterms....rticlekey=23606
" Single nucleotide polymorphisms in Caspase-3 gene is associated
with lung cancer. "
http://www.prospecbi...ASP3_Human_8_50
PPAR signalling pathway.
http://www.genome.ad...a/hsa03320.html
" PPAR gamma signaling is impaired during zinc deficiency. "
http://jn.nutrition....ull/133/10/3058
in the PPAR gamma signalling pathway.
" The caspase-3 level was positively correlated with the level
of apoptosis . "
" Caspase 3 has been called the "henchman that goes around
and executes the cell. "
http://www.medterms....rticlekey=23606
" Single nucleotide polymorphisms in Caspase-3 gene is associated
with lung cancer. "
http://www.prospecbi...ASP3_Human_8_50
PPAR signalling pathway.
http://www.genome.ad...a/hsa03320.html
" PPAR gamma signaling is impaired during zinc deficiency. "
http://jn.nutrition....ull/133/10/3058