47 replies to this topic

[tham]

http://www.thefreeli......-a0170019716


Oldenlandia diffusa acts vide caspase 2 and 3.

Together with Scutellaria barbata, this is a common herb
in Chinese herbal formulas for detoxification which you
can find selling along road side stalls in Malaysia.


http://www.jcimjourn...x?articleID=585

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum



Lindera strychnifolia. Note that SBC-3 is a SCLC line.

http://www.ncbi.nlm....l=pubmed_docsum

http://www.kalyx.com...1010.0/file.htm

Edited by tham, 19 February 2009 - 07:12 PM.

[JLL]

Don't know if this has been posted, but:

Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors.

The anticancer potency of green tea and its individual components is being intensely investigated, and some cancer patients already self-medicate with this 'miracle herb' in hopes of augmenting the anticancer outcome of their chemotherapy. Bortezomib (Velcade(®)) is a proteasome inhibitor in clinical use for multiple myeloma. Here, we investigated whether the combination of these compounds would yield increased antitumor efficacy in multiple myeloma and glioblastoma cell lines in vitro and in vivo. Unexpectedly, we discovered that various green tea constituents, in particular (-)-epigallocatechin gallate (EGCG) and other polyphenols with 1,2-benzenediol moieties, effectively prevented tumor cell death induced by bortezomib in vitro and in vivo. This pronounced antagonistic function of EGCG was only evident with boronic acid-based proteasome inhibitors (bortezomib, MG-262, PS-IX), but not with several non-boronic acid proteasome inhibitors (MG-132, PS-I, nelfinavir). EGCG directly reacted with bortezomib and blocked its proteasome inhibitory function; as a consequence, bortezomib could not trigger endoplasmic reticulum stress or caspase-7 activation, and did not induce tumor cell death. Taken together, our results indicate that green tea polyphenols may have the potential to negate the therapeutic efficacy of bortezomib and suggest that consumption of green tea products may be contraindicated during cancer therapy with bortezomib.

http://www.ncbi.nlm....pubmed/19190249

[tham]

Good find. Bill should avoid green tea extracts and EGCG
if Kurt decides to give him bortezomib.

[tham]

David Sadava of Claremont College was kind enough to send me
immediately the full study of his abstract on Oldenladia diffusa,
Glycyrrhiza glabra, PC-SPES and SPES, after I requested it from him.

http://www.ncbi.nlm....l=pubmed_docsum


http://www.claremont...file.asp?Fac=80

http://www.jsd.clare...sp?FacultyID=29


Glycryrrhiza glabra is licorice.

Shortly after this study, PC-SPES and SPES were taken off
the market and the marketing company, Botanic Lab, closed
down after somewhat overblown fears of PC-SPES being
contaminated with warfarin and SPES with alprazolam (Xanax).

http://www.nature.co...l/1206242a.html

http://www.annieappl...alonpcspes.html

http://www.phoenix5....2602pcspes.html

http://www.lef.org/m..._profile_01.htm

Attached Files

•  OLDENLANDIA_DIFFUSA.pdf   160.09KB   2 downloads

Edited by tham, 23 February 2009 - 05:00 PM.

[tham]

Looking at Dr Sadava's study (concluding discussion) above :

" The similarities in IC50 between drug-sensitive and multidrug
-resistant cells indicates that these extracts are not affected
by the drug resistance mechanisms displayed in H69VP (drug
resistant SCLC line), including overexpression of two drug
transporters, MDR1 and MRP (drug pumps). "

In Table 1, Oldenlandia diffusa is slightly more cytotoxic (IC50
of 0.99 mg/ml) than PC-SPES (1.23 mg/dl) and significantly more
than SPES (1.71 mg/dl) on the H69VP line.

Glycyrrhiza glabra (licorice) is ruled out due to its hypertension
side effect at the relatively high dosages required. Its cytotoxicity
on SCLC is due to necrosis rather than apoptosis, due to
overexpression of Bcl-2.

PC-SPES was originally developed for hormone refractory prostate
cancer, but also exhibits cytotoxic activity in other cancers, including
SCLC.

http://www.aacrmeeti...act/2004/1/691-


Its performance in prostate cancer appears impressive, so
the outcry by prostate cancer patients in the links above
when it was taken off markets was justified.

http://jn.nutrition....full/131/1/164S

[tham]

More on PC-SPES.

It is now being remanufactured by a UK company, Active Botanicals Ltd, as PC-SPES 2, with improved qualitiy control.

http://www.ncbi.nlm....l=pubmed_docsum

http://www.findowner...ls-ltd/2688038/



http://jn.nutrition....ll/132/11/3513S

http://meeting.ascop...ourcetype=HWCIT

http://www.ncbi.nlm....l=pubmed_docsum

http://cat.inist.fr/...&cpsidt=1269479

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum


Its upregulation/inhibition of the proapoptotic/antiapoptotic genes,
BAX, Bcl-2, Bcl-xL, caspase 3 and the tumor suppressor genes, p21
and p53, would explain its activity against SCLC as well.

[tham]

Replacement link for the missing AACR abstract above :

http://www.aacrmeeti...ourcetype=HWCIT


Drug pumps in SCLC.

http://www.aacrmeeti...ourcetype=HWCIT

[tham]

Chemo + TCM :

http://www.ncbi.nlm....st_uids=2544304

http://www.ncbi.nlm....st_uids=7867442


Alternating chemo protocols :

http://www.ncbi.nlm....st_uids=2994472

http://www.ncbi.nlm....st_uids=7786823

[tham]

Abraxane, third-generation nanoparticle albumin-bound (nab-) paclitaxel.

The Malaysian Prime Minister's first wife died of breast cancer
in 2005 shortly after returning from Abraxane therapy in LA.
Her twin sister died from the same disease in 2002.

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://en.wikipedia....i/Endon_Mahmood






Docataxel (Taxotere), second generation taxane.

http://www.asco.org/...abstractID=2872

http://www.asco.org/...bstractID=33392

http://www.ncbi.nlm....l=pubmed_docsum

http://www.asco.org/...bstractID=13876

http://www.asco.org/...abstractID=2881

http://www.ncbi.nlm....l=pubmed_docsum


Marimastat.

http://www.asco.org/...p;abstractID=11

[tham]

Requires registration to access.

http://www.medscape....warticle/416475

[tunt01]

anyone know of any good protocols/suggestions for NSCLC? preferably for ex-smokers?

i have a family member who is an ex-smoker needs some sort of regiment to inhibit their cancer risk (they don't have it yet, but early stages/immune dysfunction signals are ominous).

[tham]

anyone know of any good protocols/suggestions for NSCLC? preferably for ex-smokers?

i have a family member who is an ex-smoker needs some sort of regiment to inhibit their cancer risk (they don't have it yet, but early stages/immune dysfunction signals are ominous).

In Malaysia, you can commonly find vendors selling "cooling"
herbal drinks by the roadside.

These drinks are a concoction of herbs for general detoxification
and typically include two very common herbs used in tradional
Chinese Medicine :

Oldenlandia diffusa
Scutellaria barbata, or a related species, Scutellaria baicalensis

All three have anticancer activity against NSCLC, with Oldenlandia
also active against SCLC.


You could make a herbal drink of Oldenlandia and either of
the Scutellaria species, taking it say twice a week for prevention.

They can be found as whole herbs, powders, extracts or granules
in any Chinese herbal store. Extracts or granules are more
convenient. Extracts need only be steeped in hot water. Granules
are the most convenient - they dissolve instantly in hot or room
temperature water and drunk like a beverage. Whole herbs or
powders would need to be boiled for a few hours before their
essence is extracted.

http://www.kalyx.com...2855.0/file.htm

http://www.kalyx.com...6020.0/file.htm

http://www.kalyx.com...D/10.0/file.htm

http://www.kalyx.com...6020.0/file.htm


http://www.itmonline...oldenlandia.htm

http://www.cancerdec...81504_page.html


http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum


A549 is an NSCLC adenocarcinoma line.

http://www.ncbi.nlm....l=pubmed_docsum


Scutellaria baicalensis's anticancer actions are due largely
to its flavonoids, baicalen, baicalin, wogonin and chrysin.

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum


Another herb which you could substitute in place of Scutellaria
is Lindera strychifolia, which has activity against both SCLC
and NSCLC.

SBC-3 is an SCLC line frequently used in testing drug resistance.

http://www.ncbi.nlm....l=pubmed_docsum

http://www.kalyx.com...1010.0/file.htm

http://www.kalyx.com...6020.0/file.htm


A suggested dosage might be 1/3 to 1/2 teaspoon each of
the extracts or granules of the following in a glass of water
(extracts in hot water) taken twice a week. Otherwise, you
could ask the owner or counter staff of any Chinese herbal
store there for advice.

Oldenlandia
Scutellaria or Lindera


Frankly, Bill should be taking Oldenlandia and Lindera regularly,
but I wonder why he doesn't seem to have shown much interest.

http://www.ncbi.nlm....l=pubmed_docsum

[tham]

http://www.cancer.go...in_061207/page5

[tham]

Posting here too for easier reference.


The rationale for including imatinib is because it is also a
BCRP inhibitor.

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://cancerres.aac.../full/64/7/2333


Expression of BCRP is linked to poor survival in SCLC.

http://www.ncbi.nlm....l=pubmed_docsum

[tham]

Here's a lucky long term survivor, partly attributed to topotecan.

http://www.ncbi.nlm....l=pubmed_docsum


Platinum-based chemo protocols have no advantage in survival
over non-platinum ones, and in fact worsens quality of life.
This is why I've never favoured Kurt giving Bill cisplatin and
then carboplatin.

http://www.ncbi.nlm....l=pubmed_docsum


Scottish SCLC patients fare worse than their counterparts in
British Columbia.

http://www.ncbi.nlm....l=pubmed_docsum


Raised serum urea before chemo worsens survival.

http://www.ncbi.nlm....l=pubmed_docsum

[tham]

SCLC is extremely difficult to treat with chemotherapy.
Many of the latest drug regimens have good responses,
but so far none of them have made any difference to
survival times over the past 20 or 30 years.

Resistance rapidly sets in after the initial response.

http://www.ncbi.nlm....l=pubmed_docsum


This is why I had suggested to Bill that he try alternative
medicine like homeopathy or perhaps traditional Chinese
medicine, along with methyl jasmonate and the other
adjuvant drugs, herbs and supplements, excluding resveratrol
and quercetin.

[bixbyte]

anyone know of any good protocols/suggestions for NSCLC? preferably for ex-smokers?

i have a family member who is an ex-smoker needs some sort of regiment to inhibit their cancer risk (they don't have it yet, but early stages/immune dysfunction signals are ominous).

Here is a Cancer "Cure" medication approved only for use in Russia called NOV-002
Currently being tested under FDA Phase III trials under Special Protocol Assessment and Fast Track in the USA.
The test patients appear to be failing to die from their cancer and the tests has been continued for an extra 6 months and might be continued for even another 3 or 6 more months!

Standard Chemo 17%
NOV-002 adjunctive with Chemo Increased Cancer survival to 63%

http://www.novelos.com/

http://www.novelos.c...ls_frameset.htm

http://en.wikipedia.org/wiki/NOV-002

http://www.cancer.go...earchid=2669713

http://clinicaltrial...how/NCT00347412


If you need this medicine right away and have a lot of money you can make an appointment, the only Doctor, for the "Cure"

http://www.tiopoietine.info/index.htm

Good Luck!

Bix

[tham]

Rehmannia Six formula, Liu Wei Di Huang Wan.

http://www.ncbi.nlm....st_uids=1963383