Sunifiram
20 May 2004
http://www.ncbi.nlm....4&dopt=Abstract
If you do a search on that website you come up with a few other studies, I don't think there is any healthy adult studies on this though.
DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer.
Ghelardini C, Galeotti N, Gualtieri F, Romanelli MN, Bucherelli C, Baldi E, Bartolini A.
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G. Pieraccini 6, 50139 Florence, Italy. ghelard@pharm.unifi.it
DM235 (sunifiram), a new compound structurally related to piracetam, prevented the amnesia induced by scopolamine (1.5 mg kg(-1) i.p.), after intraperitoneal (0.001-0.1 mg kg(-1)) or oral (0.01-0.1 mg kg(-1)) administration, as shown by a passive avoidance test in mice. The antiamnesic effect of DM235 was comparable to that of well-known nootropic drugs such as piracetam (30-100 mg kg(-1) i.p.), aniracetam (100 mg kg(-1) p.o.) or rolipram (30 mg kg(-1) p.o.). DM235 also prevented mecamylamine (20 mg kg(-1) i.p.)-, baclofen (2 mg kg(-1) i.p.)- and clonidine (0.125 mg kg(-1) i.p.)-induced amnesia in the same test. In the Morris water maze test with rats, scopolamine (0.8 mg kg(-1) i.p.) inhibited the reduction of escape latency in both acquisition and retention/retraining tests. DM235 (0.1 mg kg(-1) i.p.), 20 min before each daily acquisition training, prevented the scopolamine-induced memory impairment. DM235 (1 mg kg(-1) i.p.) also reduced the duration of pentobarbitone-induced hypnosis in mice without modifying the induction time of hypnosis. At the highest effective doses, the investigated compound neither impaired motor coordination (rota-rod test), nor modified spontaneous motility and inspection activity (Animex and hole board tests).These results indicate that DM235, a compound structurally related to piracetam, is a novel nootropic endowed with the capability to prevent cognitive deficits at very low doses. Indeed, its potency is about 1,000 times higher than that of the most active piracetam-like compounds.
PMID: 12070754 [PubMed - indexed for MEDLINE]
shpongled 21 May 2004
21 May 2004
http://www.ncbi.nlm....t_uids=11087574
More articles. It seems like this drug is quite experimental (or not I couldn't be sure), waiting for it's FDA approval could take many years, if it's ever approved for a disease. If it isn't available through chemical suppliers in China as I've heard then it might be harder to source than I thought, but at 1000 times the potency of piracetam like compounds it might be worth the fight. We shall see...
shpongled 23 May 2004
Potency does not necessarily correlate with maximal activity. Racetam nootropics tend to have bell-shaped dose-response curves. So the question you want answered is not how potent a compound is, but how strong the effect is at the dose which has the maximal effect.
Accordingly, here is a quote from one of the sunifiram studies:
The maximal antiamnesic effect of DM235 was obtained with the dose of 0.001 mg kg–1 i.p. and maintained up to 0.1 mg kg–1 i.p. The DM235-induced antiamnesic effect was of the same intensity as that exerted by the well-known nootropic drugs piracetam (30 mg kg–1 i.p.), aniracetam (100 mg kg–1 p.o.) or rolipram (30 mg kg–1 p.o.) (Fig. 2A and B).
There are no human studies on this compound. So we know nothing about the toxicity, side effects, or pharmacokinetics in humans. I agree that it is promising, but self-experimentation with drugs like this - especially ones with an active dose of 1 mcg/kg - is dangerous. Not only that, but with a bell-shaped dose response curve, you have to hit a very narrow dosage range to achieve an effect, which is much more difficult if the doses are miniscule. It is possible that even a fraction of a milligram too much could make it so it had no nootropic effect at all.
shpongled 23 May 2004
23 May 2004
Guest_Isochroma_* 22 Aug 2009
The reason is that by being so much more potent, it can be manufactured very cheaply! Imagine, paying only $10 or $20 for a month's supply of this miracle molecule. It is also unregulated... think business! A pinch added to bottles of soda, cans of anything imaginable. No taste at the active dose means consumer acceptance. Reforming the minds of the masses and making money like nothing else can
Shipping costs per kilodose will be ridiculously low. The low cost of this new power means a high Return on Investment, or benefit-ratio or EROEI. That is a very powerful implication. It must be explored, and soon. Time for a custom synth and wide distro. Count me in.
Edited by Isochroma, 22 August 2009 - 10:08 PM.
Isochroma 29 Nov 2012
Their prices - including EMS shipping to my door - are: $88, $100, $115, $130, $150, $200 for 1g.
All have it in stock.
Dosage is 5mg for a 150lb person.
There are 200 doses per gram. This molecule is actually 1000x more potent than Piracetam - unlike Noopept which is only 100x more potent.
At 200 doses per gram, the price per dose for each seller respectively is: $0.44, $0.50, $0.58, $0.75, $1.00.
If anyone is interested to try it please reply or PM me.
I am likely to buy a gram on January 5 2012.
lifebuddy 05 Dec 2012
Isochroma 05 Dec 2012
For reasons of potential future business I haven't decided to make the list public yet.
I will be thinking about it in the coming days.
megatron 08 Dec 2012
Isochroma 08 Dec 2012
Somebody will have to be first or nobody can be there anywhere anywhen.
noot_in_the_sky 09 Dec 2012
Bit of a catch-22 circular argument isn't it?
Somebody will have to be first or nobody can be there anywhere anywhen.
You can give a few samples away, once people have it they might think: "What the hell?", and take 1. It's what some supplement companies do.
Edited by noot_in_the_sky, 09 December 2012 - 12:12 AM.
megatron 09 Dec 2012
Edited by Megatrone, 09 December 2012 - 01:07 PM.
noot_in_the_sky 09 Dec 2012
https://www.ncbi.nlm...pubmed/12070754
Which states the use an oral administration of (0.01-0.1 mg kg(-1) in mice, which @ .1mg/kg converts to .0081mg/kg in human. Or is my math of?
Isochroma 09 Dec 2012
I say the dose will be less than Noopept's 25mg. But we don't know because no human has yet taken this molecule, or if they did they kept their results secret.
Sombody is going to have to investigate by taking various doses. What's most important is that activity is retained over a 10:1 ratio.
This molecule has an n-shaped dose-response curve in animals so the right dose will work and doses above and below it won't work.
lifebuddy 10 Dec 2012
Isochroma 10 Dec 2012
Right now I can't even get an in-house COA from my Chinese friends.
Now I have a bad taste in my mouth from the ten grams of corn-starch that loser Nootrabiolabs sold me on eBay for $76.94.
I'm not interested in buying more corn-starch for $100+ per gram. Chinese corn-starch doesn't taste any better than the American kind.
My payday is coming up next week and I don't have any reason to believe that any of the five Chinese sellers have the real DM-235.
That means I will be buying 500g Oxiracetam from my trusted Chinese supplier instead.
Stick with the best, reject the rest.
And don't bother buying Nootrabiolabs' 'Phenylpiracetam' on eBay or anywhere else. It's a fraud. At best it's Russian Roulette - I suspect he's sending out some real PP and the other half or 30% of shipments are 100% inert powder with poor solubility characteristics and lacking the slight bitterness that has already been noted by others on this forum which characterizes real Phenylpiracetam.
This way he can claim that it's real because some % of buyers get an effect. He can claim that it's the buyer's inconsistent responses to the drug instead of the fact that every second or third of his 'Phenylpiracetam' shipments is inert powder.
A certain % of his buyers will randomly receive the real thing and the rest will get inert powder. It's the perfect scheme. I might try it myself. As P.T. Barnum said, "There's a sucker born every minute".
Edited by Isochroma-Reborn, 10 December 2012 - 01:34 AM.
lifebuddy 10 Dec 2012
Isochroma 10 Dec 2012
In fact, one reason less to trust him:
On November 29, 2012 I sent him this message via eBay messenger:
"I bought 10g Phenylpiracetam from Nootrabiolabs here on eBay.
Didn't do a damn thing, total waste of money.
Also it didn't dissolve in water and had no taste.
How do I know yours isn't fake too? Maybe it's the same as NTB's."
I received a reply (the only reply I have received to date) from him the next day:
"We'll go ahead and check the physical properties to ensure it dissolves/has recognizable taste. We also have a CoA (Certificate of Analysis) we will send along to you as well.
Cheers!
The Elevated Labs Team"
So they will ensure that their fraud resembles the real thing, will they?
He never replied with the COA as he promised to.
I won't be sending my money to jokers like him even if his material is real. His foolish response indicates he never comprehended my question.
Edited by Isochroma-Reborn, 10 December 2012 - 03:23 AM.
lifebuddy 10 Dec 2012
I agree that he didn't comprehend your question. If they had gone to the trouble of importing a strange and unusual chem from a new company (they are only a month old themselves), they should have at least tested their products with some basic physical tests ALREADY. Otherwise they are taking advantage of others one by one until they get enough "duff" responses to wake up.
Isochroma 10 Dec 2012
It was there yesterday.
Thieves in the night.
Edit: He reposted the sale but an eBay search doesn't find it because it's bid-only - there's no Buy it Now like his previous sale.
Edited by Isochroma-Reborn, 10 December 2012 - 03:50 AM.
noot_in_the_sky 10 Dec 2012
Can HSW be behind both BYOB and Nexus??
Nexsus
http://www.ebay.com/itm/30-Grams-Pramiracetam-Bulk-Powder-/140816435217?pt=LH_DefaultDomain_0&hash=item20c9504811
BYOB
http://www.ebay.com/itm/Pramiracetam-50-Grams-Bulk-Powder-/180943887061?pt=LH_DefaultDomain_0&hash=item2a21189ad5
Health Supplement Wholesale
http://healthsupplementwholesalers.com/
Edited by noot_in_the_sky, 10 December 2012 - 02:36 PM.
Isochroma 10 Dec 2012
megatron 10 Dec 2012
They are one and the same company, and also OK. I received nice fresh 100g Pramiracetam from them a month ago.
Have you ordered Sunifiram yet? You should test it yourself first, before starting distributing to others. Also, do you resell Prami? If so, how much do you charge?