LONGECITY

I want to develop software against aging, what kind of software a biogerontologist need? I want to invest my money into bioinformatics
research for aging. Feel free to visit my page here:

http://www.nanoaging...showpage&pid=47

--Jon

You know, aging is a very complex process that includes lots of sophistications and brunches.

It's like *aging* and that's it. There are plenty of things I believe we don't think of that comes with aging.

Tiniest example- the grinding of the gristle, which the body does not provide a replacement; the lost of these tiny hairs in the ears that makes us lose our ability of hearing, in the end- they shall all fall and bring us to deafness... And there are plenty more small things we don't think of when we think of aging.

I saw a while ago a program about aging, and they have demonstrated one of the biggest problems, very nicely put.

Take a picture of yourself and photocopy in a black and white photocopying machine. Now take the the result and make an experiment.
Simply copy it. and then copy the copy. and then, copy the copy... etcetera, etcetera...
You'll see that the most recent copy is less evident.
In the end you'll see nothing.
This is exactly what happened to us.
The cells simply get harmed with time in to inability to copy, or copy a defective one, as every once in a time there are few lagging... Till nothing lefts. Well, yet we die before all are defected. It is not an easy case, to stop mishap from happening, after all, these are simply incidents, they happen. Unfortunately people are so firmly fixed on it being natural. How sad. They do not even bother listening, and those who do prefer ignoring or not comprehending because they don't want to be wrong, or go *against the grain*.

You should decide which part of the aging thing you wish to focus on. There are lots of aging theories.

Yours
~Infernity

Have you considered resource allocation models? Here is a recent article by Kirkwood in this area:


Mech Ageing Dev. 2005 Jan;126(1):99-103.
Modelling the disposable soma theory of ageing.

Drenos F, Kirkwood TB.

School of Clinical Medical Sciences-Gerontology, Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK.

We describe a mathematical model, developed using the Mathematica programming system of the disposable soma theory of ageing. The model makes explicit predictions about the optimal strategies for investment in somatic maintenance versus investments in growth and reproduction and confirms the central prediction of the disposable soma theory that the optimum investment in somatic maintenance is less than what would be required for indefinite longevity. We also describe how the optimal investment in maintenance is affected by varying the parameters that specify the schedules of reproduction and mortality.

PMID: 15610767 [PubMed - indexed for MEDLINE]

Have you considered resource allocation models? Here is a recent article by Kirkwood in this area:


Mech Ageing Dev. 2005 Jan;126(1):99-103.
Modelling the disposable soma theory of ageing.

Drenos F, Kirkwood TB.

School of Clinical Medical Sciences-Gerontology, Henry Wellcome Laboratory for Biogerontology Research, Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne NE4 6BE, UK.

PMID: 15610767 [PubMed - indexed for MEDLINE]

Where did you get this text ? I want the url please

--Jon

Anyone interested to enter in the mailing list and begin to work with me? The job is to search for programmers that want to help cure aging.

--Jon

I need someone able to contact everyone aging researchers on the ellison medical foundation web site.

We will ask them if they need some software and that we can provide them some programmers for free.

Are you interested to do this job for me please ?


--Jon

This is the PubMed link

This entire issue of Mechanisms of Ageing and Development is freely available on www.sciencedirect.com, so I am attaching the whole thing.

Jon,
Here's a place where members suppose to fill in their Media, but no one but three did.

http://www.imminst.o...&f=63&t=6591&s=

See if they can fill it...

Yours
~Infernity

Funny you mention hair cells. That happens to be one of the classical examples that have been fixed in mice with embryonic stem cell therapy, already 2 years ago.

Take a picture of yourself and photocopy in a black and white photocopying machine. Now take the the result and make an experiment.
Simply copy it. and then copy the copy. and then, copy the copy... etcetera, etcetera...
You'll see that the most recent copy is less evident.
In the end you'll see nothing.
This is exactly what happened to us.
The cells simply get harmed with time in to inability to copy, or copy a defective one, as every once in a time there are few lagging...

Actually, Infernity, that's not a good model of aging. Life is digital (genetic code), not analog. Like digital music, life is intrinsically capable of replicating its essential aspects perfectly across millions and millions of cell divisions. Our germ cells do exactly that. As Mike West likes to point out, the cells of your body are part of a living legacy of protoplasm that has been continuously dividing and faithfully preserving the machinery of life FOR THREE BILLION YEARS.

We age as individuals for the same reason our skin cells slough off and die: Individuals, like skin cells, have evolved as expendable elements in a grand scheme that keeps living machinery going for eons. In other words, aging of individual organisms evolved as a consequence of individual expendability in the perpetuation of genes, not because life is intrinsically incapable of making good cell copies. There is no basic reason our somatic cells, with a few tweaks, could not perform with the same stability and essentially unlimited replicative capacity of our germ line.

The belief that life by nature must always "wear out" is perhaps the most common misconception about biological immortality. Life's innate capacity for renewal and pepetuation of correct cell operation is worth remembering.

---BrianW

I see the PubMed link here but I want the long paper not only the abstract please.

http://www.ncbi.nlm....0767&query_hl=1

ok I have it above forgive my stupidity

If you have other papers or links about bioinformatics aging then let me know here.

Hey, can you make or find a program that would make copy-past'ing references from pubmed easier? Ideally, the program would integrate into windows and whenever I copy something out of pubmed, it would know it, and remove any pictures, sometimes links, dates of publication (leave only the year) and transform it into a plain-text, well formated citation, in times new roman, size 10 ect.? (If I must, I would also click *one* button for it per ref) Later, you could implement other features such as custom formats and automatically converting between different formats.
This could really save a lot of time to a lot of people I think.

I don't have a lot of spare time, but I will help with any programming you need. I have been programming for a living 4 years now and was an amature for 6 years before that.

I think another gap in the market of life-science software in general is stereoscopic 3d vizualization. I have often spent ages trying to align different projections of cells or proteins against each other to find out just where something is in 3d space. If you made a stereoscopic picture/anim instead, you could directly see it, but most commercial vizualization software makers simply don't seem to think of that possibility.

You're very right.

Both astronomy and life-sciences could use 3-D navigable images. The number of times I've rotated an enzyme in my head is beyond count (and I guess as an exercise it's good for staving off brain decay), but woof! it's tough.