LONGECITY

Thanks Harkjin. In previous videos, I cut saturated fat intake while maintaining a relatively high total fat intake, and that didn't move glucose back into the 80s. After doing that experiment, that's why I'm now going after total fat intake, which has a stronger correlation with glucose than any of the individual fats (i.e. MUFA, O3, O6, SFA).

Nice short review and recap. Liked Table 2 (Representative articles about the use of omics to study the effect of food bioactivity.)

Ignacio Ortea,
Foodomics in health: Advanced techniques for studying the bioactive role of foods,
https://doi.org/10.1...rac.2022.116589.
(https://www.scienced...165993622000723)

Abstract: This review illustrates how the use of the latest omics technologies is being applied to investigate the effect of diets, foods or food components on health/disease status. Bioactive food components alter gene expression and protein levels and functions, leading to various beneficial effects on human health. Gene variants and expression, epigenetic regulation, protein levels and post-translational modifications, as well as metabolites, can be analyzed and integrated globally to obtain functional information. Foodomics, integrating the study of food and nutrition with omics technologies, allows the investigation of cellular processes, functional mechanisms and molecules involved, as well as the definition of targets for bioactive compounds useful for the development of nutritional intervention strategies, and the discovery of biomarkers linking nutrition and health. In addition, the main limitations of the use of these approaches are discussed, as well as the trends that will be applied in the area in the near future, providing a broad and updated view.

Interesting perspective on PN

Berciano S, Figueiredo J, Brisbois TD, et al. Precision nutrition: Maintaining scientific integrity while realizing market potential. Front Nutr. 2022;0.

https://www.frontier...022.979665/full

I've been reading about PN (and nutrigenomics) since 2003, and progress has been exceedingly slow. That's the main reason why I track diet and blood test so frequently, to do it myself instead.

Aribadabar, the process is described in the link "learn more" next to the downloaded vcf file. You basically need to open the file (and search your rs) using the "glogg" program (you have the installation link in the description of the process which is given for Mac or PC). Here is the image I get when I search in the file rs603424. The "learn more" link also has a section "understanding VCF value" with the interpretation of the symbols. To keep on topic please feel free to PM me if you still have issues.

dnaland.PNG

rs603424.PNG

https://glogg.bonnefon.org/

Great recent read from real, long term experts in the field of PN:

Kaput J, Monteiro JP, Morine MJ, Kussmann M. Personalized nutrition. In: Reference Module in Biomedical Sciences. Elsevier; 2022:B9780128240106000000.

https://www.scienced...000034?via=ihub

Yes, it must be so. I have a somewhat reverse problem with my test done as early as 2011. E.g. I was looking at rs603424 which is "not genotyped" for me but actually other folks have it reported. It is an important SNP in the SDC1 gene strongly influencing the free fatty acids palmitic to palmitoleic ratio I wish to research on for me. I did not do it yet but some recommend to use DNA.LAND to infer it. I posted before on this and if I am successful in getting information on this SNP I will let you know how the process works. You might wish to try for yourself.

As the site DNA.LAND is no longer active I retrieved via the waybackmachine the FAQs

https://web.archive....://dna.land/faq

A market perspective:

Will the market for personalized nutrition reach maturity in 2023?

https://www.foodinsp...turity-in-2023/

Old thread but wish to log here two recent articles by a consultant professional I follow describing what so far went well and wrong in the area and future challenges:

https://www.linkedin...-panzeri-2erye/

https://www.linkedin...-panzeri-fzzse/

Adherence to healthy dietary patterns can prevent the development of non-communicable diseases and affect life expectancy. Here, using a prospective population-based cohort data from the UK Biobank, we show that sustained dietary change from unhealthy dietary patterns to the Eatwell Guide dietary recommendations is associated with 8.9 and 8.6 years gain in life expectancy for 40-year-old males and females, respectively. In the same population, sustained dietary change from unhealthy to longevity-associated dietary patterns is associated with 10.8 and 10.4 years gain in life expectancy in males and females, respectively. The largest gains are obtained from consuming more whole grains, nuts and fruits and less sugar-sweetened beverages and processed meats. Understanding the contribution of sustained dietary changes to life expectancy can provide guidance for the development of health policies.

Fadnes LT, Celis-Morales C, Økland JM, et al. Life expectancy can increase by up to 10 years following sustained shifts towards healthier diets in the United Kingdom. Nat Food. 2023;4(11):961-965.
https://www.nature.c...016-023-00868-w
 

Are any of the DNA variant analysis companies out there good at creating personalized nutrition and supplement plans from SNPs?  (Apologies if this was answered earlier in the thread)

Interesting approved clinical trial:

Nutrition for Precision Health, Powered by the All of Us

https://clinicaltria...udy/NCT05701657

The goal of this investigational study is to develop algorithms that predict human response to foods. The main question it aims to answer are:

• How does varying foods and eating patterns impact one's biological and physiological responses?
• In what ways can novel dietary assessment measures be used to improve dietary assessments and to prescribe assessments to people in future research with increased precision?
• Can artificial intelligence and machine learning techniques be combined to prescribe foods and eating patterns to individuals for optimization of their health?

Great speakers alignment:

https://hsph.harvard...mics-symposium/

On coffee … I intermittently fast in the morning, typically 18h since last food intake the previous day. I hope I do not interrupt the supposedly benefits of fasting with coffee though. Any thoughts on this point?

https://www.longecit...ndpost&p=933853

Massive study. Liked and posted by David Furman on LI:

https://www.nature.c...025-03570-5.pdf